Apnea, Obstructive Sleep, also known as obstructive sleep apnea syndrome, is related to obesity-hypoventilation syndrome and acromegaly, and has symptoms including apnea, back pain and cheyne-stokes respiration. An important gene associated with Apnea, Obstructive Sleep is LEP (Leptin), and among its related pathways/superpathways are Metabolism of proteins and Signal Transduction. The drugs Opium and Acetazolamide have been mentioned in the context of this disorder. Affiliated tissues include heart and tongue, and related phenotypes are anosmia and obstructive sleep apnea