Anismus is related to diarrhea and pelvic organ prolapse. An important gene associated with Anismus is GUCA2B (Guanylate Cyclase Activator 2B), and among its related pathways/superpathways is Digestion and absorption. The drugs Lidocaine and Nitroglycerin have been mentioned in the context of this disorder. Affiliated tissues include colon, and related phenotype is cardiovascular system.