Anus Disease, also known as anal fissure, is related to anal fistula and skin tag, and has symptoms including abdominal pain, constipation and diarrhea. An important gene associated with Anus Disease is FREM2 (FRAS1 Related Extracellular Matrix 2), and among its related pathways/superpathways are Nervous system development and 22q11.2 copy number variation syndrome. The drugs Nitric Oxide and Acetylcholine have been mentioned in the context of this disorder. Affiliated tissues include colon and skin, and related phenotypes are homeostasis/metabolism and nervous system