Amyotrophic Lateral Sclerosis 12 with or Without Frontotemporal Dementia, also known as als12, is related to amyotrophic lateral sclerosis type 12 and frontotemporal dementia. An important gene associated with Amyotrophic Lateral Sclerosis 12 with or Without Frontotemporal Dementia is OPTN (Optineurin). Affiliated tissues include spinal cord and brain, and related phenotypes are muscle weakness and emg: positive sharp waves