Amyotrophic Lateral Sclerosis 5, Juvenile, also known as als5, is related to amyotrophic lateral sclerosis type 5 and amyotrophic lateral sclerosis 1, and has symptoms including muscular fasciculation, muscle spasticity and abnormal pyramidal signs. An important gene associated with Amyotrophic Lateral Sclerosis 5, Juvenile is SPG11 (SPG11 Vesicle Trafficking Associated, Spatacsin). Affiliated tissues include spinal cord and brain, and related phenotypes are abnormal pyramidal sign and distal muscle weakness