Amyotrophic Lateral Sclerosis 18, also known as amyotrophic lateral sclerosis type 18, is related to lateral sclerosis and amyotrophic lateral sclerosis 1. An important gene associated with Amyotrophic Lateral Sclerosis 18 is PFN1 (Profilin 1), and among its related pathways/superpathways is Amyotrophic lateral sclerosis (ALS). Affiliated tissues include spinal cord and brain, and related phenotypes are spasticity and dysarthria