Amyotrophic Lateral Sclerosis 2, Juvenile, also known as als2, is related to locked-in syndrome and amyotrophic lateral sclerosis type 15, and has symptoms including upper motor neuron signs An important gene associated with Amyotrophic Lateral Sclerosis 2, Juvenile is ALS2 (Alsin Rho Guanine Nucleotide Exchange Factor ALS2), and among its related pathways/superpathways is Amyotrophic lateral sclerosis (ALS). Affiliated tissues include spinal cord and brain, and related phenotypes are spasticity and scoliosis