Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex 1 (ALS-PDC1)

Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex 1, also known as guam disease, is related to frontotemporal dementia and/or amyotrophic lateral sclerosis 4 and amyotrophic lateral sclerosis 19, and has symptoms including tremor, bradykinesia and abnormality of extrapyramidal motor function. An important gene associated with Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex 1 is TRPM7 (Transient Receptor Potential Cation Channel Subfamily M Member 7), and among its related pathways/superpathways are Neuroscience and Copper homeostasis. The drugs Olanzapine and Risperidone have been mentioned in the context of this disorder. Affiliated tissues include bone marrow and spinal cord, and related phenotypes are cerebral atrophy and dementia