Amelogenesis Imperfecta, Type Iv (AI4)

Amelogenesis Imperfecta, Type Iv, also known as hypomaturation-hypoplastic amelogenesis imperfecta with taurodontism, is related to amelogenesis imperfecta, hypomaturation type, iia2 and amelogenesis imperfecta, type iiia. An important gene associated with Amelogenesis Imperfecta, Type Iv is DLX3 (Distal-Less Homeobox 3), and among its related pathways/superpathways is Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs). Related phenotypes are yellow-brown discoloration of the teeth and enamel hypoplasia