Alzheimer Disease 4, also known as ad4, is related to early-onset autosomal dominant alzheimer disease and agraphia. An important gene associated with Alzheimer Disease 4 is PSEN2 (Presenilin 2), and among its related pathways/superpathways are Alzheimer's disease and miRNA effects and Neuroscience. Affiliated tissues include cortex and brain, and related phenotypes are cerebral amyloid angiopathy and dementia