Aggressive Nk-Cell Leukemia, also known as nk-cell large granular lymphocyte leukemia, is related to composite lymphoma and aplastic anemia, and has symptoms including fever An important gene associated with Aggressive Nk-Cell Leukemia is NCAM1 (Neural Cell Adhesion Molecule 1), and among its related pathways/superpathways are NF-kappaB Signaling and Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. The drugs Prednisone and Thalidomide have been mentioned in the context of this disorder. Affiliated tissues include nk cells and bone marrow, and related phenotypes are immune system and hematopoietic system