Aggressive Systemic Mastocytosis (ASM)

Aggressive Systemic Mastocytosis, also known as lymphadenopathic mastocytosis with eosinophilia, is related to systemic mastocytosis and mast-cell leukemia. An important gene associated with Aggressive Systemic Mastocytosis is ASXL1 (ASXL Transcriptional Regulator 1), and among its related pathways/superpathways are Infectious disease and MIF Mediated Glucocorticoid Regulation. The drugs Brentuximab vedotin and D-Tyrosine have been mentioned in the context of this disorder. Affiliated tissues include liver and skin, and related phenotypes are abnormal mast cell morphology and hypotension