African Tick-Bite Fever, also known as african tick bite fever, is related to boutonneuse fever and spotted fever, and has symptoms including fever, eschar and maculopapular rash. An important gene associated with African Tick-Bite Fever is PLEKHG4 (Pleckstrin Homology And RhoGEF Domain Containing G4), and among its related pathways/superpathways are MIF Mediated Glucocorticoid Regulation and A-beta Uptake and Degradation. Affiliated tissues include skin and endothelial, and related phenotype is cardiovascular system.