Adrenal Cortical Hypofunction, also known as adrenal cortical insufficiency, is related to premature ovarian failure 7 and achalasia-addisonianism-alacrima syndrome. An important gene associated with Adrenal Cortical Hypofunction is NR0B1 (Nuclear Receptor Subfamily 0 Group B Member 1), and among its related pathways/superpathways are Metabolism of steroids and Metabolism of steroid hormones. Affiliated tissues include adrenal cortex and cortex, and related phenotypes are Reduced mammosphere formation and homeostasis/metabolism