Acute Megakaryocytic Leukemia, also known as acute megakaryoblastic leukemia, is related to childhood acute megakaryoblastic leukemia and down syndrome. An important gene associated with Acute Megakaryocytic Leukemia is GATA1 (GATA Binding Protein 1), and among its related pathways/superpathways are Signal Transduction and ERK Signaling. The drugs Etoposide and Aldesleukin have been mentioned in the context of this disorder. Affiliated tissues include myeloid and bone marrow, and related phenotypes are Reduced mammosphere formation and homeostasis/metabolism