Acth-Independent Macronodular Adrenal Hyperplasia 1, also known as aimah1, is related to acth-independent macronodular adrenal hyperplasia and basophil adenoma, and has symptoms including agitation An important gene associated with Acth-Independent Macronodular Adrenal Hyperplasia 1 is GNAS (GNAS Complex Locus), and among its related pathways/superpathways are G-Beta Gamma Signaling and G alpha (s) signalling events.