Acth-Independent Macronodular Adrenal Hyperplasia (AIMAH1)

Acth-Independent Macronodular Adrenal Hyperplasia, also known as cushing syndrome due to macronodular adrenal hyperplasia, is related to acth-independent macronodular adrenal hyperplasia 1 and cushing syndrome due to bilateral macronodular adrenocortical disease, and has symptoms including agitation and generalized fatigue. An important gene associated with Acth-Independent Macronodular Adrenal Hyperplasia is GNAS (GNAS Complex Locus), and among its related pathways/superpathways are Class A/1 (Rhodopsin-like receptors) and GPCR downstream signalling. The drugs Racepinephrine and Hydrocortisone have been mentioned in the context of this disorder. Affiliated tissues include adrenal gland and pituitary, and related phenotypes are emotional lability and depression