Acute Pulmonary Heart Disease is related to thrombophilia due to thrombin defect and pulmonary embolism. An important gene associated with Acute Pulmonary Heart Disease is PPP6R2 (Protein Phosphatase 6 Regulatory Subunit 2), and among its related pathways/superpathways are ACE Inhibitor Pathway, Pharmacodynamics and Network map of SARS-CoV-2 signaling pathway. Affiliated tissues include heart, and related phenotypes are muscle and cardiovascular system