Acute Necrotizing Encephalitis, also known as postinfectious acute necrotizing hemorrhagic encephalopathy, is related to encephalitis and intracranial hypertension. An important gene associated with Acute Necrotizing Encephalitis is RANBP2 (RAN Binding Protein 2), and among its related pathways/superpathways are Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway and COVID-19 adverse outcome pathway. Affiliated tissues include brain and temporal lobe, and related phenotypes are Increased hepcidin::fluc mRNA expression and growth/size/body region