Aicardi-Goutieres Syndrome 8, also known as ags8, is related to leiomyosarcoma and prostate leiomyosarcoma. An important gene associated with Aicardi-Goutieres Syndrome 8 is LSM11 (LSM11, U7 Small Nuclear RNA Associated). Affiliated tissues include brain and endothelial, and related phenotypes are irritability and severe global developmental delay