Acquired Idiopathic Sideroblastic Anemia (AISA)

Acquired Idiopathic Sideroblastic Anemia, also known as refractory anemia with ringed sideroblasts, is related to mitochondrial myopathy and refractory cytopenia with multilineage dysplasia. An important gene associated with Acquired Idiopathic Sideroblastic Anemia is MT-CO1 (Mitochondrially Encoded Cytochrome C Oxidase I), and among its related pathways/superpathways are Gene expression (Transcription) and TP53 Regulates Metabolic Genes. The drugs Methotrexate and Cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include bone marrow and myeloid, and related phenotypes are refractory anemia with ringed sideroblasts and anemia of inadequate production