Acne Inversa, Familial, 2, with or Without Dowling-Degos Disease, also known as acne inversa, familial, 2, is related to acne inversa, familial, 1 and acne inversa, familial, 3. An important gene associated with Acne Inversa, Familial, 2, with or Without Dowling-Degos Disease is PSENEN (Presenilin Enhancer, Gamma-Secretase Subunit). Affiliated tissues include skin and heart, and related phenotypes are recurrent cutaneous abscess formation and chronic furunculosis