Acne, also known as frontalis acne, is related to pyogenic sterile arthritis, pyoderma gangrenosum, and acne and sapho syndrome, and has symptoms including exanthema and pruritus. An important gene associated with Acne is NCSTN (Nicastrin), and among its related pathways/superpathways are Innate Immune System and Prolactin Signaling. The drugs Calcipotriol and Chlorhexidine have been mentioned in the context of this disorder. Affiliated tissues include skin and ovary, and related phenotypes are homeostasis/metabolism and renal/urinary system