Acanthosis Nigricans

Acanthosis Nigricans, also known as keratosis nigricans, is related to pineal hyperplasia, insulin-resistant diabetes mellitus, and somatic abnormalities and familial partial lipodystrophy, and has symptoms including pruritus An important gene associated with Acanthosis Nigricans is PRMT7 (Protein Arginine Methyltransferase 7), and among its related pathways/superpathways are Signal Transduction and TGF-Beta Pathway. The drugs Metformin and Leuprolide have been mentioned in the context of this disorder. Affiliated tissues include skin and ovary, and related phenotypes are acanthosis nigricans and Increased shRNA abundance (Z-score > 2)