Achalasia, also known as cardiospasm, is related to achalasia-addisonianism-alacrima syndrome and megaesophagus. An important gene associated with Achalasia is AAAS (Aladin WD Repeat Nucleoporin), and among its related pathways/superpathways are Metabolism and G-Beta Gamma Signaling. The drugs Fentanyl and Oxycodone have been mentioned in the context of this disorder. Affiliated tissues include smooth muscle and liver, and related phenotypes are homeostasis/metabolism and nervous system