Mus Musculus
Ube3a - ubiquitin protein ligase E3A
Alias:
Hpve6a
4732496B02
5830462N02Rik
A130086L21Rik
Basic Information
Enables transcription coactivator activity and ubiquitin protein ligase activity. Involved in positive regulation of Golgi lumen acidification and regulation of circadian rhythm. Acts upstream of or within several processes, including cellular protein metabolic process; positive regulation of phosphatidylinositol 3-kinase signaling; and reproductive structure development. Located in cytosol and nucleus. Is expressed in central nervous system and retina. Used to study Angelman syndrome. Human ortholog(s) of this gene implicated in Angelman syndrome. Orthologous to human UBE3A (ubiquitin protein ligase E3A). [provided by Alliance of Genome Resources, Apr 2022]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Models
Reference
Ube3a Genetics information (Positive Sense)
- Chr
Sequence Homology
Humans, mice, and rats have highly similar genes, making them important for disease research and drug development. By studying their gene relationships, researchers can develop effective treatments for both humans and animals. Gene homology among these organisms allows for the translation of animal experimental results to humans, improving disease treatment and prevention.
Orthologs:
No Orthologs
Transcripts & Proteins
Transcripts are RNA molecules that are created during DNA transcription, and the translation products of these transcripts are proteins that serve numerous roles in the body. Transcripts and proteins are both important in biological research. The research of transcripts can help us uncover the subtle links between genes and illnesses, whereas the study of proteins can help us understand the processes of cellular function and disease etiology, as well as give prospective treatment targets.
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Transcript
Length(nt)
Exon count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
The level of gene activity in a particular tissue or cell can be identified by its expression. Understanding the physiological processes and disease causes of organisms depends heavily on the specificity of gene expression levels in various tissues or cells. A thorough examination of the tissue and cell specificity of gene expression will contribute to the understanding of the genetic basis of disease and offer novel approaches to both prevent and cure disease.
Tissue-specific RNA expression
Organ
Expression
Alphabetical
Cell-specific RNA expression
Organ
Expression
Alphabetical
Protein Interaction
Protein-protein interaction is when two or more proteins bind together to perform their functions. It plays a vital role in most biochemical processes, such as signal molecules transmitting signals between cells. Molecular machines within the cells perform important functions through protein-protein interactions.
Acting
Regulation
Detail
Mechanism
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Score
References
Within the biological sciences, gene-related research literature is a valuable and essential resource. They meticulously document the composition, operation, and interaction of genes, giving us important hints to solve the enigmas surrounding life.
Title
PMID
Journal
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Comparison
BioGPT