LOCUS       NM_001415801            2469 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus zyxin (Zyx), transcript variant 4, mRNA.
ACCESSION   NM_001415801
VERSION     NM_001415801.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2469)
  AUTHORS   Schiefermeier,N., Scheffler,J.M., de Araujo,M.E., Stasyk,T.,
            Yordanov,T., Ebner,H.L., Offterdinger,M., Munck,S., Hess,M.W.,
            Wickstrom,S.A., Lange,A., Wunderlich,W., Fassler,R., Teis,D. and
            Huber,L.A.
  TITLE     The late endosomal p14-MP1 (LAMTOR2/3) complex regulates focal
            adhesion dynamics during cell migration
  JOURNAL   J Cell Biol 205 (4), 525-540 (2014)
   PUBMED   24841562
REFERENCE   2  (bases 1 to 2469)
  AUTHORS   Bianchi-Smiraglia,A., Kunnev,D., Limoge,M., Lee,A., Beckerle,M.C.
            and Bakin,A.V.
  TITLE     Integrin-beta5 and zyxin mediate formation of ventral stress fibers
            in response to transforming growth factor beta
  JOURNAL   Cell Cycle 12 (21), 3377-3389 (2013)
   PUBMED   24036928
REFERENCE   3  (bases 1 to 2469)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   4  (bases 1 to 2469)
  AUTHORS   Kuo,J.C., Han,X., Hsiao,C.T., Yates,J.R. 3rd and Waterman,C.M.
  TITLE     Analysis of the myosin-II-responsive focal adhesion proteome
            reveals a role for beta-Pix in negative regulation of focal
            adhesion maturation
  JOURNAL   Nat Cell Biol 13 (4), 383-393 (2011)
   PUBMED   21423176
REFERENCE   5  (bases 1 to 2469)
  AUTHORS   Trost,M., English,L., Lemieux,S., Courcelles,M., Desjardins,M. and
            Thibault,P.
  TITLE     The phagosomal proteome in interferon-gamma-activated macrophages
  JOURNAL   Immunity 30 (1), 143-154 (2009)
   PUBMED   19144319
REFERENCE   6  (bases 1 to 2469)
  AUTHORS   Cattaruzza,M., Lattrich,C. and Hecker,M.
  TITLE     Focal adhesion protein zyxin is a mechanosensitive modulator of
            gene expression in vascular smooth muscle cells
  JOURNAL   Hypertension 43 (4), 726-730 (2004)
   PUBMED   14967842
  REMARK    GeneRIF: Zyxin plays a role in transducing mechanical stimuli from
            the cell membrane to the nucleus in vascular SMCs and in
            controlling the expression of mechanosensitive genes that have been
            implicated in hypertension-induced arterial remodeling.
REFERENCE   7  (bases 1 to 2469)
  AUTHORS   Schick,B., Praetorius,M., Eigenthaler,M., Mack,A., Plinkert,P.,
            Walter,U., Dazert,S. and Knipper,M.
  TITLE     Expression of VASP and zyxin in cochlear pillar cells: indication
            for actin-based dynamics?
  JOURNAL   Cell Tissue Res 311 (3), 315-323 (2003)
   PUBMED   12658439
  REMARK    GeneRIF: In pillar cells, VASP and zyxin were co-localised with
            pan-actin, suggesting actin-based dynamics in these cochlear cells.
REFERENCE   8  (bases 1 to 2469)
  AUTHORS   Marie,H., Pratt,S.J., Betson,M., Epple,H., Kittler,J.T., Meek,L.,
            Moss,S.J., Troyanovsky,S., Attwell,D., Longmore,G.D. and Braga,V.M.
  TITLE     The LIM protein Ajuba is recruited to cadherin-dependent cell
            junctions through an association with alpha-catenin
  JOURNAL   J Biol Chem 278 (2), 1220-1228 (2003)
   PUBMED   12417594
REFERENCE   9  (bases 1 to 2469)
  AUTHORS   Cattaruzza,M., Schafer,K. and Hecker,M.
  TITLE     Cytokine-induced down-regulation of zfm1/splicing factor-1 promotes
            smooth muscle cell proliferation
  JOURNAL   J Biol Chem 277 (8), 6582-6589 (2002)
   PUBMED   11748220
REFERENCE   10 (bases 1 to 2469)
  AUTHORS   Macalma,T., Otte,J., Hensler,M.E., Bockholt,S.M., Louis,H.A.,
            Kalff-Suske,M., Grzeschik,K.H., von der Ahe,D. and Beckerle,M.C.
  TITLE     Molecular characterization of human zyxin
  JOURNAL   J Biol Chem 271 (49), 31470-31478 (1996)
   PUBMED   8940160
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.1958382.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-87                JAXUCZ010000004.1  72204000-72204086
            88-307              JAXUCZ010000004.1  72204636-72204855
            308-510             JAXUCZ010000004.1  72205322-72205524
            511-603             JAXUCZ010000004.1  72205669-72205761
            604-1098            JAXUCZ010000004.1  72205872-72206366
            1099-1219           JAXUCZ010000004.1  72210484-72210604
            1220-1389           JAXUCZ010000004.1  72210728-72210897
            1390-1568           JAXUCZ010000004.1  72210998-72211176
            1569-1689           JAXUCZ010000004.1  72211883-72212003
            1690-2469           JAXUCZ010000004.1  72212402-72213181
FEATURES             Location/Qualifiers
     source          1..2469
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q24"
     gene            1..2469
                     /gene="Zyx"
                     /note="zyxin"
                     /db_xref="GeneID:114636"
                     /db_xref="RGD:620698"
     exon            1..87
                     /gene="Zyx"
                     /inference="alignment:Splign:2.1.0"
     exon            88..307
                     /gene="Zyx"
                     /inference="alignment:Splign:2.1.0"
     CDS             100..1794
                     /gene="Zyx"
                     /note="isoform 1 is encoded by transcript variant 4"
                     /codon_start=1
                     /product="zyxin isoform 1"
                     /protein_id="NP_001402730.1"
                     /db_xref="GeneID:114636"
                     /db_xref="RGD:620698"
                     /translation="MAAPRPPPAISVSVSAPAFYAPQKKFAPVVAPKPKVNPFRPGDS
                     ESPVAAGAQRAQMGRVGEIPPPPPEDFPLPPPPVIGEGDDSEGALGGAFPPPPPPLIE
                     EPFPPAPLEEDIFPSPPPPLEEEGGPEAPTQLPPQPREKVSSIDLEIDSLSSLLDDMT
                     KNDPFKARVSSGYVPPPVATPFVPKPSTKPAPVGTAPLPPWKAPSSSQPPPQPQAKPQ
                     VQLHAQPQAKPHVQPQSVSSANTQPRGPLSQAPTPAPKFAPVAPKFTPVASKFSPGAP
                     SGPGPQPSQKSVPLEAPSSVGTGSPQPPSFTYAQQKEKPLVQEKQHPLPPPAQNQNQV
                     RSPGGPGPLTLKEVEELEQLTQQLMQDMEHPQRQSVAVNESCGKCSQPLARAQPAVRA
                     LGQLFHITCFTCHQCQQQLQGQQFYSLEGAPYCEGCYTDTLEKCNTCGQPITDRMLRA
                     TGKAYHPHCFTCVVCACPLEGTSFIVDQANQPHCVPDYHKQYAPRCSVCSEPIMPEPG
                     RDETVRVVALDKNFHMKCYKCEDCGKALSIEADDNGCFPLDGHVLCRKCHSARAQT"
     exon            308..510
                     /gene="Zyx"
                     /inference="alignment:Splign:2.1.0"
     exon            511..603
                     /gene="Zyx"
                     /inference="alignment:Splign:2.1.0"
     exon            604..1098
                     /gene="Zyx"
                     /inference="alignment:Splign:2.1.0"
     exon            1099..1219
                     /gene="Zyx"
                     /inference="alignment:Splign:2.1.0"
     exon            1220..1389
                     /gene="Zyx"
                     /inference="alignment:Splign:2.1.0"
     exon            1390..1568
                     /gene="Zyx"
                     /inference="alignment:Splign:2.1.0"
     exon            1569..1689
                     /gene="Zyx"
                     /inference="alignment:Splign:2.1.0"
     exon            1690..2469
                     /gene="Zyx"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aatggcaggc aggcccggga agcgggactg agcagcttcg ggacctctgg gatactcgcc
       61 ggcctgcaca gccccggagt gcggacgccc ggcctgacta tggcggcccc ccgcccgcct
      121 cccgcgatct ccgtctcggt ctcggccccc gcgttttacg ccccgcagaa gaagttcgcc
      181 ccggttgtgg ccccgaagcc caaagtgaat cctttccggc ctggggacag cgagtctcct
      241 gtggcagccg gggcccagag agcacagatg ggccgggtgg gcgagatccc cccaccgccc
      301 ccggaagact ttcctttgcc ccctcctccc gttattgggg agggcgacga ctcagagggg
      361 gccctgggag gtgccttccc acctccacct cccccgttga tcgaagaacc attcccccct
      421 gctcctctgg aggaggacat cttcccctcc cctccacctc cactggagga ggagggagga
      481 cctgaggccc ctacccagct cccaccgcag cccagggaga aagtgagcag tattgacctg
      541 gagatcgact ctctgtcctc actgctggat gacatgacca agaacgatcc cttcaaagcc
      601 cgggtgtcat ctggatatgt acctccacca gttgctactc catttgttcc caaacctagt
      661 accaagcctg cccctgtggg cacagcaccc ttacctcctt ggaaggcccc ttctagctct
      721 cagccaccac ctcagccgca ggccaagcct caggtccagc tccatgccca gcctcaggcc
      781 aagccccatg tccaacccca gtctgtgtct tccgctaata cacagccccg aggtcccctt
      841 tctcaggctc caactccagc acctaagttt gctccagtgg cacctaaatt tactcccgtg
      901 gcttccaaat tcagccctgg tgctccaagt ggacctgggc cacagcccag tcaaaaatcg
      961 gtgcctctgg aagctccttc ttctgtgggc acaggctccc cccagccccc tagcttcacc
     1021 tatgctcagc agaaggagaa gcccctagtt caagagaagc agcacccact gcctccacca
     1081 gctcaaaacc aaaaccaggt acgttctcct ggaggcccag gccccttgac cctgaaggag
     1141 gtggaagagt tggagcagct gacccagcag ctgatgcagg acatggagca ccctcagagg
     1201 cagagcgtgg cagtaaatga gtcctgtggc aaatgcagtc agccactggc ccgagcacag
     1261 cctgcagtcc gtgcactggg acaactgttc catatcacct gcttcacttg tcatcagtgt
     1321 cagcagcagc tgcagggaca gcagttctat agcctggagg gggcaccata ttgtgagggc
     1381 tgctacactg acactctgga gaagtgcaac acttgtgggc agcccatcac tgaccgaatg
     1441 ctgagggcca ctggcaaagc ctaccaccca cattgcttca cctgtgtggt ctgcgcctgt
     1501 cccctggagg gcacttcctt cattgtggac caggccaatc agccccactg tgttcctgac
     1561 tatcacaagc aatatgctcc aaggtgctct gtctgctcgg agcccatcat gcctgagcct
     1621 ggccgggatg agactgtgcg agtagtcgcg ctggataaga actttcatat gaagtgttac
     1681 aagtgtgagg actgtgggaa agccctgtcc attgaggcag atgacaacgg ctgtttccct
     1741 ctggatggcc atgtcctttg tcggaagtgc cactctgcta gagcccagac ctgagttgaa
     1801 gatggacctc cttccacacc acaggtccat cccccaccgt ggaccaccca cagaggccag
     1861 tccttgcctc caccctccct gcattccaaa tccctccctt gtgtctcaag tgccctgacc
     1921 cagggcccca gcatggccta gaagtactga ggctccgtcc tggtgctgag gcccagccct
     1981 gggctccaac ccttgcctct tctgcaggga tcacctatca tcctgaggcc cccaacccaa
     2041 gggtcacatt tagtgctgct gctttcactg ctgcaccaat gcccttggct ggcctgagca
     2101 gcctatgcaa tgtgcttgct gagggtggaa gccccaaccc tctgggaacg tggctccagc
     2161 agcctggaca cccaccttgc tctgtgctgc taggttgtgg ccacagctaa gattataaaa
     2221 cctcattttc cagaattgct agcacttggt tttttgataa taccctatac tcttggagtt
     2281 gaaataaagg gtcttgatgg ggaaaaagat caggggaggg ataaaaactc aactctgttt
     2341 atttacaaaa atagataatg catatgtaag tatatatatt aaaccctccc cccagcaccc
     2401 acccacccac agtccccttc acttgtaccc cacccacccc ctttataaac aaaggctcct
     2461 tggtccaaa
//
