LOCUS       NP_001402730             564 aa            linear   ROD 30-MAR-2024
DEFINITION  zyxin isoform 1 [Rattus norvegicus].
ACCESSION   NP_001402730
VERSION     NP_001402730.1
DBSOURCE    REFSEQ: accession NM_001415801.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 564)
  AUTHORS   Schiefermeier,N., Scheffler,J.M., de Araujo,M.E., Stasyk,T.,
            Yordanov,T., Ebner,H.L., Offterdinger,M., Munck,S., Hess,M.W.,
            Wickstrom,S.A., Lange,A., Wunderlich,W., Fassler,R., Teis,D. and
            Huber,L.A.
  TITLE     The late endosomal p14-MP1 (LAMTOR2/3) complex regulates focal
            adhesion dynamics during cell migration
  JOURNAL   J Cell Biol 205 (4), 525-540 (2014)
   PUBMED   24841562
REFERENCE   2  (residues 1 to 564)
  AUTHORS   Bianchi-Smiraglia,A., Kunnev,D., Limoge,M., Lee,A., Beckerle,M.C.
            and Bakin,A.V.
  TITLE     Integrin-beta5 and zyxin mediate formation of ventral stress fibers
            in response to transforming growth factor beta
  JOURNAL   Cell Cycle 12 (21), 3377-3389 (2013)
   PUBMED   24036928
REFERENCE   3  (residues 1 to 564)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   4  (residues 1 to 564)
  AUTHORS   Kuo,J.C., Han,X., Hsiao,C.T., Yates,J.R. 3rd and Waterman,C.M.
  TITLE     Analysis of the myosin-II-responsive focal adhesion proteome
            reveals a role for beta-Pix in negative regulation of focal
            adhesion maturation
  JOURNAL   Nat Cell Biol 13 (4), 383-393 (2011)
   PUBMED   21423176
REFERENCE   5  (residues 1 to 564)
  AUTHORS   Trost,M., English,L., Lemieux,S., Courcelles,M., Desjardins,M. and
            Thibault,P.
  TITLE     The phagosomal proteome in interferon-gamma-activated macrophages
  JOURNAL   Immunity 30 (1), 143-154 (2009)
   PUBMED   19144319
REFERENCE   6  (residues 1 to 564)
  AUTHORS   Cattaruzza,M., Lattrich,C. and Hecker,M.
  TITLE     Focal adhesion protein zyxin is a mechanosensitive modulator of
            gene expression in vascular smooth muscle cells
  JOURNAL   Hypertension 43 (4), 726-730 (2004)
   PUBMED   14967842
  REMARK    GeneRIF: Zyxin plays a role in transducing mechanical stimuli from
            the cell membrane to the nucleus in vascular SMCs and in
            controlling the expression of mechanosensitive genes that have been
            implicated in hypertension-induced arterial remodeling.
REFERENCE   7  (residues 1 to 564)
  AUTHORS   Schick,B., Praetorius,M., Eigenthaler,M., Mack,A., Plinkert,P.,
            Walter,U., Dazert,S. and Knipper,M.
  TITLE     Expression of VASP and zyxin in cochlear pillar cells: indication
            for actin-based dynamics?
  JOURNAL   Cell Tissue Res 311 (3), 315-323 (2003)
   PUBMED   12658439
  REMARK    GeneRIF: In pillar cells, VASP and zyxin were co-localised with
            pan-actin, suggesting actin-based dynamics in these cochlear cells.
REFERENCE   8  (residues 1 to 564)
  AUTHORS   Marie,H., Pratt,S.J., Betson,M., Epple,H., Kittler,J.T., Meek,L.,
            Moss,S.J., Troyanovsky,S., Attwell,D., Longmore,G.D. and Braga,V.M.
  TITLE     The LIM protein Ajuba is recruited to cadherin-dependent cell
            junctions through an association with alpha-catenin
  JOURNAL   J Biol Chem 278 (2), 1220-1228 (2003)
   PUBMED   12417594
REFERENCE   9  (residues 1 to 564)
  AUTHORS   Cattaruzza,M., Schafer,K. and Hecker,M.
  TITLE     Cytokine-induced down-regulation of zfm1/splicing factor-1 promotes
            smooth muscle cell proliferation
  JOURNAL   J Biol Chem 277 (8), 6582-6589 (2002)
   PUBMED   11748220
REFERENCE   10 (residues 1 to 564)
  AUTHORS   Macalma,T., Otte,J., Hensler,M.E., Bockholt,S.M., Louis,H.A.,
            Kalff-Suske,M., Grzeschik,K.H., von der Ahe,D. and Beckerle,M.C.
  TITLE     Molecular characterization of human zyxin
  JOURNAL   J Biol Chem 271 (49), 31470-31478 (1996)
   PUBMED   8940160
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.1958382.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..564
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q24"
     Protein         1..564
                     /product="zyxin isoform 1"
                     /calculated_mol_wt=60173
     Region          <3..295
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          <177..>396
                     /region_name="PRK10263"
                     /note="DNA translocase FtsK; Provisional"
                     /db_xref="CDD:236669"
     Region          343..429
                     /region_name="LIM"
                     /note="LIM is a small protein-protein interaction domain,
                     containing two zinc fingers; cl02475"
                     /db_xref="CDD:413332"
     Site            order(376,379,398,401,404,407,425,428)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:188735"
     Region          436..495
                     /region_name="LIM2_Zyxin"
                     /note="The second LIM domain of Zyxin; cd09353"
                     /db_xref="CDD:188739"
     Site            order(436,439,456,459,462,465,484,487)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:188739"
     Region          496..562
                     /region_name="LIM3_Zyxin"
                     /note="The third LIM domain of Zyxin; cd09435"
                     /db_xref="CDD:188819"
     Site            order(496,499,523,526,529,532,554,557)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:188819"
     CDS             1..564
                     /gene="Zyx"
                     /coded_by="NM_001415801.1:100..1794"
                     /note="isoform 1 is encoded by transcript variant 4"
                     /db_xref="GeneID:114636"
                     /db_xref="RGD:620698"
ORIGIN      
        1 maaprpppai svsvsapafy apqkkfapvv apkpkvnpfr pgdsespvaa gaqraqmgrv
       61 geippppped fplppppvig egddsegalg gafppppppl ieepfppapl eedifpsppp
      121 pleeeggpea ptqlppqpre kvssidleid slssllddmt kndpfkarvs sgyvpppvat
      181 pfvpkpstkp apvgtaplpp wkapsssqpp pqpqakpqvq lhaqpqakph vqpqsvssan
      241 tqprgplsqa ptpapkfapv apkftpvask fspgapsgpg pqpsqksvpl eapssvgtgs
      301 pqppsftyaq qkekplvqek qhplpppaqn qnqvrspggp gpltlkevee leqltqqlmq
      361 dmehpqrqsv avnescgkcs qplaraqpav ralgqlfhit cftchqcqqq lqgqqfysle
      421 gapycegcyt dtlekcntcg qpitdrmlra tgkayhphcf tcvvcacple gtsfivdqan
      481 qphcvpdyhk qyaprcsvcs epimpepgrd etvrvvaldk nfhmkcykce dcgkalsiea
      541 ddngcfpldg hvlcrkchsa raqt
//
