LOCUS       NM_001012021            2218 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus zinc finger and SCAN domain containing 21
            (Zscan21), mRNA.
ACCESSION   NM_001012021 XM_222000
VERSION     NM_001012021.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2218)
  AUTHORS   Dermentzaki G, Paschalidis N, Politis PK and Stefanis L.
  TITLE     Complex Effects of the ZSCAN21 Transcription Factor on
            Transcriptional Regulation of alpha-Synuclein in Primary Neuronal
            Cultures and in Vivo
  JOURNAL   J Biol Chem 291 (16), 8756-8772 (2016)
   PUBMED   26907683
  REMARK    GeneRIF: the unaltered SNCA levels observed following ZSCAN21
            down-regulation in the rat brain, possibly due to compensatory
            mechanisms, imply that ZSCAN21 is not a master regulator of SNCA in
            vivo.
REFERENCE   2  (bases 1 to 2218)
  AUTHORS   Clough RL, Dermentzaki G and Stefanis L.
  TITLE     Functional dissection of the alpha-synuclein promoter:
            transcriptional regulation by ZSCAN21 and ZNF219
  JOURNAL   J Neurochem 110 (5), 1479-1490 (2009)
   PUBMED   19549071
  REMARK    GeneRIF: Transcription factor zinc finger and SCAN domain
            containing (ZSCAN)21, which binds to a site within intron 1, is a
            key regulator of alpha-synuclein transcription in neuronal cells.
REFERENCE   3  (bases 1 to 2218)
  AUTHORS   Ellerton EL, Thompson WJ and Rimer M.
  TITLE     Induction of zinc-finger proliferation 1 expression in
            non-myelinating Schwann cells after denervation
  JOURNAL   Neuroscience 153 (4), 975-985 (2008)
   PUBMED   18440155
  REMARK    GeneRIF: Zipro1 is a good candidate for a transcription factor
            involved in activation of non-myelinating cervical sympathetic
            trunk.
REFERENCE   4  (bases 1 to 2218)
  AUTHORS   Gebelein B, Mesa K and Urrutia R.
  TITLE     A novel profile of expressed sequence tags for zinc finger encoding
            genes from the poorly differentiated exocrine pancreatic cell line
            AR4IP
  JOURNAL   Cancer Lett 105 (2), 225-231 (1996)
   PUBMED   8697448
REFERENCE   5  (bases 1 to 2218)
  AUTHORS   Yang XW, Zhong R and Heintz N.
  TITLE     Granule cell specification in the developing mouse brain as defined
            by expression of the zinc finger transcription factor RU49
  JOURNAL   Development 122 (2), 555-566 (1996)
   PUBMED   8625807
REFERENCE   6  (bases 1 to 2218)
  AUTHORS   Chowdhury K, Goulding M, Walther C, Imai K and Fickenscher H.
  TITLE     The ubiquitous transactivator Zfp-38 is upregulated during
            spermatogenesis with differential transcription
  JOURNAL   Mech Dev 39 (3), 129-142 (1992)
   PUBMED   1284028
REFERENCE   7  (bases 1 to 2218)
  AUTHORS   Noce T, Fujiwara Y, Sezaki M, Fujimoto H and Higashinakagawa T.
  TITLE     Expression of a mouse zinc finger protein gene in both
            spermatocytes and oocytes during meiosis
  JOURNAL   Dev Biol 153 (2), 356-367 (1992)
   PUBMED   1397691
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            FM121830.1, BC079435.1 and BG379149.1.
            
            On Jan 1, 2009 this sequence version replaced NM_001012021.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079435.1, SRR8487226.103453.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-52                FM121830.1         1-52
            53-2197             BC079435.1         1-2145
            2198-2218           BG379149.1         1-21                c
FEATURES             Location/Qualifiers
     source          1..2218
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q11"
     gene            1..2218
                     /gene="Zscan21"
                     /gene_synonym="Zipro1"
                     /note="zinc finger and SCAN domain containing 21"
                     /db_xref="GeneID:304342"
                     /db_xref="RGD:1309981"
     exon            1..81
                     /gene="Zscan21"
                     /gene_synonym="Zipro1"
                     /inference="alignment:Splign:2.1.0"
     exon            82..796
                     /gene="Zscan21"
                     /gene_synonym="Zipro1"
                     /inference="alignment:Splign:2.1.0"
     CDS             167..1831
                     /gene="Zscan21"
                     /gene_synonym="Zipro1"
                     /note="zinc finger proliferation 1"
                     /codon_start=1
                     /product="zinc finger and SCAN domain-containing protein
                     21"
                     /protein_id="NP_001012021.1"
                     /db_xref="GeneID:304342"
                     /db_xref="RGD:1309981"
                     /translation="MTKVVGMATVLGPRPPQESMGPSPIKVEEDEEKDKCRPSLELSR
                     KRFRQSRNQDTLEPMGPSTIKAEEEEDKDKGHPSLELSRKSFKQFGYHDTLEQLGPST
                     VKAEEDEEKDKGRPSLEISRQRFRQFGYHDTPGPREALSQLRVLCCEWLQPEIHTKEQ
                     ILELLVLEQFLTILPRELQAWVQQHCPESAEEAVTLLEDLEQELDEPGLQVSSPNEQK
                     QSWEKISTSGTAMESLSSTETQPVDASPKYEFWGPLYIQETGEEEVFTQDPRKRQGFK
                     LNPQKEDSADEQRSSEEESHAGGLKRNIMPMITANKYGSRSERQWANNLERERGAKAS
                     LQDTGSRKGAEPASARPAPGEKRYICAECGKAFSNSSNLTKHRRTHTGEKPYVCTKCG
                     KAFSHSSNLTLHYRTHLVDRPYDCKCGKAFGQSSDLLKHQRMHTEEAPYQCKDCGKAF
                     SGKGSLIRHYRIHTGEKPYQCNECGKSFSQHAGLSSHQRLHTGEKPYKCKECGKAFNH
                     SSNFNKHHRIHTGEKPYWCNHCGKTFCSKSNLSKHQRVHTGEGEVQ"
     exon            797..986
                     /gene="Zscan21"
                     /gene_synonym="Zipro1"
                     /inference="alignment:Splign:2.1.0"
     exon            987..2203
                     /gene="Zscan21"
                     /gene_synonym="Zipro1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccggttgtgc tatggttcag ccgctgtgag gattccagac tccaaagcgg ttctgagtca
       61 cggtgagcct gcgagtccca ggtttggagt gtggcacttt aagaaccaga aacccaaagg
      121 ctccaggcct actcctaaga gtcctgctgg ttctggagtc tgtgtcatga ccaaggtggt
      181 gggcatggcc acagttctgg gccccaggcc acctcaggag tctatgggac cttcgcccat
      241 taaagttgaa gaggatgaag aaaaagacaa gtgccgccct agcctagagc tatcccgaaa
      301 gcgcttcagg cagtctagaa accaggacac tcttgagcca atgggacctt caaccattaa
      361 agctgaagag gaggaagaca aggacaaggg ccaccctagc ctagagctat cccgtaagag
      421 cttcaagcag tttgggtacc atgacacttt ggaacagttg ggaccttcga ctgttaaagc
      481 tgaagaggat gaagagaagg acaagggccg ccctagccta gagatatccc gtcagcgctt
      541 caggcagttt gggtaccatg acactcctgg gccccgagag gcactgagcc agcttcgggt
      601 gctctgctgt gagtggctac agcctgagat ccacaccaag gagcagattc tagagctact
      661 ggttctggag cagttcctga ccatcctgcc ccgagagctc caggcctggg tacagcagca
      721 ctgccctgag agtgcagagg aggccgtcac tctcctggaa gacctggagc aagaactgga
      781 tgagcctgga ctgcaggtct catctccaaa tgaacagaag cagtcttggg agaaaatatc
      841 aacttcagga actgcaatgg agtccttaag cagcactgag acccagcctg tggatgccag
      901 ccctaaatat gagttttggg ggcccctgta catccaagag actggtgaag aggaggtttt
      961 cactcaggac ccaagaaagc gccaaggttt taaattgaat ccgcagaagg aggactcagc
     1021 agatgagcag agaagttctg aagaagagtc tcatgcaggt ggactcaaaa gaaacatcat
     1081 gcccatgatc actgccaata agtatggatc gaggtcagaa aggcagtggg ccaacaacct
     1141 ggaaagggag agaggggcaa aagcctctct tcaagacacg ggatccagga aaggggcaga
     1201 accagcgtct gctaggcctg ctccaggaga gaaacgttac atatgtgcag agtgtgggaa
     1261 ggcctttagc aatagctcaa acctcactaa acaccggaga acacacactg gggagaagcc
     1321 ttacgtgtgc accaagtgtg ggaaggcttt cagccacagc tccaacctta cccttcatta
     1381 ccggacacat ctggtggacc ggccctatga ctgtaagtgt gggaaagcct ttgggcagag
     1441 ctcagacctc cttaaacatc agaggatgca cacagaagag gcgccctatc agtgtaaaga
     1501 ctgtgggaaa gccttcagtg ggaagggcag cctcattcga cactatcgca tccacacagg
     1561 ggagaagccc tatcagtgca atgagtgtgg aaagagtttt agtcagcatg caggtctcag
     1621 ttcccatcaa cgcctgcata caggggagaa accctataag tgtaaggagt gtggcaaagc
     1681 cttcaaccat agttcgaatt ttaataagca tcacagaatc catactggtg aaaaacccta
     1741 ttggtgtaac cactgtggga aaaccttctg tagcaagtca aatctttcca agcatcagag
     1801 agtccacact ggagagggag aggtacagta agtgtccatt tctgtctgtt gttattgttg
     1861 taaacgttag aatgtgaatg ctaggaagaa gctctgtaat gcatttcatg tttgatagta
     1921 ggtttggctc tagtcatcga ggggtgcctt ggagggagag ctccacagca atagagtaga
     1981 caagagaggt ctacagagca gccgggagct ccacactggt cacctctacc agcagggtcc
     2041 ctcctcacac tccaggctcc agtgtactgt gtgtccagta tagttaagga agagacatta
     2101 aaattgttta actgttttaa catgtattcc acagttgtag tttgtaaaga attgagccac
     2161 cttgaacagt ctgattcaga ataaacgtat agcatcatgt aaaaaaaaaa aaaaaaaa
//
