LOCUS       NM_001137646            2896 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus ZPR1 zinc finger (Zpr1), mRNA.
ACCESSION   NM_001137646 XM_001064960 XM_576402
VERSION     NM_001137646.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2896)
  AUTHORS   Ahmad,S., Wang,Y., Shaik,G.M., Burghes,A.H. and Gangwani,L.
  TITLE     The zinc finger protein ZPR1 is a potential modifier of spinal
            muscular atrophy
  JOURNAL   Hum Mol Genet 21 (12), 2745-2758 (2012)
   PUBMED   22422766
REFERENCE   2  (bases 1 to 2896)
  AUTHORS   Gangwani,L.
  TITLE     Deficiency of the zinc finger protein ZPR1 causes defects in
            transcription and cell cycle progression
  JOURNAL   J Biol Chem 281 (52), 40330-40340 (2006)
   PUBMED   17068332
REFERENCE   3  (bases 1 to 2896)
  AUTHORS   Doran,B., Gherbesi,N., Hendricks,G., Flavell,R.A., Davis,R.J. and
            Gangwani,L.
  TITLE     Deficiency of the zinc finger protein ZPR1 causes neurodegeneration
  JOURNAL   Proc Natl Acad Sci U S A 103 (19), 7471-7475 (2006)
   PUBMED   16648254
REFERENCE   4  (bases 1 to 2896)
  AUTHORS   Gangwani,L., Flavell,R.A. and Davis,R.J.
  TITLE     ZPR1 is essential for survival and is required for localization of
            the survival motor neurons (SMN) protein to Cajal bodies
  JOURNAL   Mol Cell Biol 25 (7), 2744-2756 (2005)
   PUBMED   15767679
REFERENCE   5  (bases 1 to 2896)
  AUTHORS   Gangwani,L., Mikrut,M., Theroux,S., Sharma,M. and Davis,R.J.
  TITLE     Spinal muscular atrophy disrupts the interaction of ZPR1 with the
            SMN protein
  JOURNAL   Nat Cell Biol 3 (4), 376-383 (2001)
   PUBMED   11283611
REFERENCE   6  (bases 1 to 2896)
  AUTHORS   Gangwani,L., Mikrut,M., Galcheva-Gargova,Z. and Davis,R.J.
  TITLE     Interaction of ZPR1 with translation elongation factor-1alpha in
            proliferating cells
  JOURNAL   J Cell Biol 143 (6), 1471-1484 (1998)
   PUBMED   9852145
REFERENCE   7  (bases 1 to 2896)
  AUTHORS   Galcheva-Gargova,Z., Gangwani,L., Konstantinov,K.N., Mikrut,M.,
            Theroux,S.J., Enoch,T. and Davis,R.J.
  TITLE     The cytoplasmic zinc finger protein ZPR1 accumulates in the
            nucleolus of proliferating cells
  JOURNAL   Mol Biol Cell 9 (10), 2963-2971 (1998)
   PUBMED   9763455
REFERENCE   8  (bases 1 to 2896)
  AUTHORS   Galcheva-Gargova,Z., Konstantinov,K.N., Wu,I.H., Klier,F.G.,
            Barrett,T. and Davis,R.J.
  TITLE     Binding of zinc finger protein ZPR1 to the epidermal growth factor
            receptor
  JOURNAL   Science 272 (5269), 1797-1802 (1996)
   PUBMED   8650580
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473975.1.
            
            On or before Nov 14, 2008 this sequence version replaced
            XM_001064960.1, XM_576402.2.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132261,
                              SAMD00132263 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2896
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q22"
     gene            1..2896
                     /gene="Zpr1"
                     /gene_synonym="RGD1562173; Zfp259"
                     /note="ZPR1 zinc finger"
                     /db_xref="GeneID:500989"
                     /db_xref="RGD:1562173"
     exon            1..204
                     /gene="Zpr1"
                     /gene_synonym="RGD1562173; Zfp259"
                     /inference="alignment:Splign:2.1.0"
     CDS             34..1413
                     /gene="Zpr1"
                     /gene_synonym="RGD1562173; Zfp259"
                     /note="zinc finger protein 259"
                     /codon_start=1
                     /product="zinc finger protein ZPR1"
                     /protein_id="NP_001131118.1"
                     /db_xref="GeneID:500989"
                     /db_xref="RGD:1562173"
                     /translation="MSASGAVQPGPPGAAVGPSPTAAALSDTGPLFRPLSAEDEEQQP
                     TEIESLCMNCYRNGTTRLLLTKIPFFREIIVSSFSCEHCGWNNTEIQSAGRIQDQGVR
                     YTLTVKGQEDMNREVVKTDSATTRIPELDFEIPAFSQKGALTTVEGLISRAILGLEQD
                     QPTRRAMEGAIAERIDEFIGKLKDLKQMASPFTLIIDDPSGNSFVENPHAPQKDSALV
                     ITYYDRTPQQAEMLGLQAEAPEEKSEEEDLRNEVLQFNTNCPECNAPAQTNMKLVQIP
                     HFKEVIIMATNCERCGHRTNEVKSGGAVEPLGTRITLHITDPSDMTRDLLKSETCSVE
                     IPELEFELGMAVLGGKFTTLEGLLKDIRELVTKNPFTLGDSSNPDQSEKLQEFSQKLG
                     QIIEGKMKAHFIMNDPAGNSYLQNVYAPEDDPEMKVERYKRSFDQNEELGLNDMKTEG
                     YEADLAPQR"
     exon            205..366
                     /gene="Zpr1"
                     /gene_synonym="RGD1562173; Zfp259"
                     /inference="alignment:Splign:2.1.0"
     exon            367..457
                     /gene="Zpr1"
                     /gene_synonym="RGD1562173; Zfp259"
                     /inference="alignment:Splign:2.1.0"
     exon            458..528
                     /gene="Zpr1"
                     /gene_synonym="RGD1562173; Zfp259"
                     /inference="alignment:Splign:2.1.0"
     exon            529..615
                     /gene="Zpr1"
                     /gene_synonym="RGD1562173; Zfp259"
                     /inference="alignment:Splign:2.1.0"
     exon            616..738
                     /gene="Zpr1"
                     /gene_synonym="RGD1562173; Zfp259"
                     /inference="alignment:Splign:2.1.0"
     exon            739..786
                     /gene="Zpr1"
                     /gene_synonym="RGD1562173; Zfp259"
                     /inference="alignment:Splign:2.1.0"
     exon            787..853
                     /gene="Zpr1"
                     /gene_synonym="RGD1562173; Zfp259"
                     /inference="alignment:Splign:2.1.0"
     exon            854..924
                     /gene="Zpr1"
                     /gene_synonym="RGD1562173; Zfp259"
                     /inference="alignment:Splign:2.1.0"
     exon            925..1014
                     /gene="Zpr1"
                     /gene_synonym="RGD1562173; Zfp259"
                     /inference="alignment:Splign:2.1.0"
     exon            1015..1125
                     /gene="Zpr1"
                     /gene_synonym="RGD1562173; Zfp259"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..1212
                     /gene="Zpr1"
                     /gene_synonym="RGD1562173; Zfp259"
                     /inference="alignment:Splign:2.1.0"
     exon            1213..1278
                     /gene="Zpr1"
                     /gene_synonym="RGD1562173; Zfp259"
                     /inference="alignment:Splign:2.1.0"
     exon            1279..2896
                     /gene="Zpr1"
                     /gene_synonym="RGD1562173; Zfp259"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccggaagctt tcactcgagt agcgcgtggg gtaatgtcgg ccagcggggc tgtgcagccc
       61 ggacctccgg gggctgccgt cggcccctcg cccaccgcgg ctgcgttatc agacaccgga
      121 cctttgttcc ggcccctcag cgccgaggat gaggagcagc agcccactga gatcgagtca
      181 ctgtgcatga actgttaccg gaacggcacg acgcgacttc tgctcactaa gatccccttc
      241 tttagagaaa taatcgtgag ctccttttcc tgtgagcact gtggctggaa caacaccgag
      301 atccagtcag caggaaggat ccaggaccaa ggagtgcgct acaccttgac cgttaagggc
      361 caagaggaca tgaacagaga agtggtgaag acagactcag ccaccacaag gatccccgag
      421 ctggattttg aaattccagc tttcagccag aagggagctc tgaccactgt ggaaggactc
      481 ataagccgcg caatcttggg cctggaacag gaccagccga cacgacgggc aatggaaggt
      541 gctatagccg aaagaattga tgagttcatt ggcaaactga aggacctaaa gcaaatggct
      601 tccccgttca cgctgatcat tgatgatccc tcgggaaaca gctttgtaga aaacccacac
      661 gctcctcaaa aagatagcgc cttggtgatc acatactacg accggacccc acagcaagct
      721 gagatgctgg ggctccaagc agaagcacca gaagagaagt cggaagagga agaccttaga
      781 aacgaagtgc tccagttcaa cacaaactgc ccagagtgca acgcccccgc tcagaccaac
      841 atgaagcttg tccaaatccc ccactttaaa gaggttatca tcatggccac caactgtgag
      901 aggtgtgggc atcggactaa tgaggtgaag tctggaggag ctgtagaacc tttgggtacc
      961 aggattaccc tccacatcac agatccctca gacatgacca gagacctcct caagtctgag
     1021 acctgtagtg tagaaatccc agagctcgag tttgaactgg gaatggctgt acttgggggc
     1081 aagttcacca ctctcgaagg actgctgaaa gacatccgag aattggtaac caaaaaccca
     1141 ttcacgctgg gcgacagctc caatcctgac cagtcagaga aactgcagga gtttagccag
     1201 aagttgggcc agatcatcga gggcaagatg aaagcccact ttatcatgaa tgatccagca
     1261 ggaaacagtt acctgcagaa cgtgtatgca cctgaagatg acccggagat gaaggtagag
     1321 cggtacaagc gctcctttga ccaaaatgag gagctcggcc tcaatgacat gaagacagag
     1381 ggctatgagg cagacctggc cccacagcgg tagcagtggg cagcccacag gccagctgca
     1441 gggcactcac actgcagggt tctttgttac tgttggagaa ggctgagtgt tcaagccctc
     1501 ctccgtggtg aggaggaaac cacctgagtt agaaatctaa gcacacgagg ttagcagctg
     1561 acaatgatgc ggctgcaggc ctactgtgct tcttgacctt cctttggcgg ttttaagtca
     1621 gtgtgagaag aacgccacaa acaccatgcg tctgccatca ccttttgtct gtcagctctc
     1681 tggcctccag tgctggacct ttgaagtctg aagtgtggag aagcgaaata caagttgcag
     1741 ctggctttgg gcttatgcag tgctaacttt cagcatagaa gaatgactga gggcaggcac
     1801 aggtaaagga gcttacatta aagtgatggc ttttaaacaa cacctgcctc ggcatttgtg
     1861 tccttcctga ataccatggt gttagagccc agctgcctaa gttgggtcac actgagtcac
     1921 acacacctgc agtcccagca tggaggatag cttgagccat agtgagattc tgtctaaatg
     1981 aaaagaaaat aggaaaaaaa attagtttcc caaacaaatc ttcaggtggc tgctgtcact
     2041 gggctgtcag aggcagcatt tcagttactc caacagacca tcgtgcctgc tctgagcccg
     2101 gcacacgtgt ggagtccagc tgttctcatg catcttaaag tagtctggaa agcagggtgg
     2161 cacatacctt aatcccagca gaagcaggcg ggtctttggg ccaatctggt ctacagagca
     2221 agttccagga cagcctgggc tacgtggaga aaccctgttt tgagacaaaa caaatcagac
     2281 tggataacct gcagcacccg tggttggccc ctgctagcaa aaaccagagc cgggcagtat
     2341 gaagatgtat gggttcctgt acttaaacaa acttagcatc tatgaaggag gctaataaaa
     2401 ctgatggcca tgtcatggtt tatacatagt cctgctactt gggaaactgg ggaagaaggg
     2461 aaacaaattt aggggcagcc tgggcaattt aatttagtaa ggtgttcaac attcaaaaag
     2521 gggtggggat gaatttatcc tatagaactc ttgcctacca tgtgtgaaag ggcttgggtt
     2581 taatcctcag caccagatga agaaaaaaca gttgtgagcg ttaagtgagt cacaaacact
     2641 taagtctata gaagaaaggc tagaatcttc ctagctttct tttctttgtc gctgaatcca
     2701 tgtcgtcttc actgggaaga ttccacatca ttttcttgag agacaatacc aaaggtgaga
     2761 aggtcagtac aggtttgata aaaacctatc aaattttcat agtcacaata ctagggatgg
     2821 agtttgactt cccctaagtg gtacctggaa gcctgttcca gacttcccac caaaggtatt
     2881 tataccatta aaagtg
//
