LOCUS       NP_001131118             459 aa            linear   ROD 03-APR-2024
DEFINITION  zinc finger protein ZPR1 [Rattus norvegicus].
ACCESSION   NP_001131118 XP_001064960 XP_576402
VERSION     NP_001131118.1
DBSOURCE    REFSEQ: accession NM_001137646.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 459)
  AUTHORS   Ahmad,S., Wang,Y., Shaik,G.M., Burghes,A.H. and Gangwani,L.
  TITLE     The zinc finger protein ZPR1 is a potential modifier of spinal
            muscular atrophy
  JOURNAL   Hum Mol Genet 21 (12), 2745-2758 (2012)
   PUBMED   22422766
REFERENCE   2  (residues 1 to 459)
  AUTHORS   Gangwani,L.
  TITLE     Deficiency of the zinc finger protein ZPR1 causes defects in
            transcription and cell cycle progression
  JOURNAL   J Biol Chem 281 (52), 40330-40340 (2006)
   PUBMED   17068332
REFERENCE   3  (residues 1 to 459)
  AUTHORS   Doran,B., Gherbesi,N., Hendricks,G., Flavell,R.A., Davis,R.J. and
            Gangwani,L.
  TITLE     Deficiency of the zinc finger protein ZPR1 causes neurodegeneration
  JOURNAL   Proc Natl Acad Sci U S A 103 (19), 7471-7475 (2006)
   PUBMED   16648254
REFERENCE   4  (residues 1 to 459)
  AUTHORS   Gangwani,L., Flavell,R.A. and Davis,R.J.
  TITLE     ZPR1 is essential for survival and is required for localization of
            the survival motor neurons (SMN) protein to Cajal bodies
  JOURNAL   Mol Cell Biol 25 (7), 2744-2756 (2005)
   PUBMED   15767679
REFERENCE   5  (residues 1 to 459)
  AUTHORS   Gangwani,L., Mikrut,M., Theroux,S., Sharma,M. and Davis,R.J.
  TITLE     Spinal muscular atrophy disrupts the interaction of ZPR1 with the
            SMN protein
  JOURNAL   Nat Cell Biol 3 (4), 376-383 (2001)
   PUBMED   11283611
REFERENCE   6  (residues 1 to 459)
  AUTHORS   Gangwani,L., Mikrut,M., Galcheva-Gargova,Z. and Davis,R.J.
  TITLE     Interaction of ZPR1 with translation elongation factor-1alpha in
            proliferating cells
  JOURNAL   J Cell Biol 143 (6), 1471-1484 (1998)
   PUBMED   9852145
REFERENCE   7  (residues 1 to 459)
  AUTHORS   Galcheva-Gargova,Z., Gangwani,L., Konstantinov,K.N., Mikrut,M.,
            Theroux,S.J., Enoch,T. and Davis,R.J.
  TITLE     The cytoplasmic zinc finger protein ZPR1 accumulates in the
            nucleolus of proliferating cells
  JOURNAL   Mol Biol Cell 9 (10), 2963-2971 (1998)
   PUBMED   9763455
REFERENCE   8  (residues 1 to 459)
  AUTHORS   Galcheva-Gargova,Z., Konstantinov,K.N., Wu,I.H., Klier,F.G.,
            Barrett,T. and Davis,R.J.
  TITLE     Binding of zinc finger protein ZPR1 to the epidermal growth factor
            receptor
  JOURNAL   Science 272 (5269), 1797-1802 (1996)
   PUBMED   8650580
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473975.1.
            
            On or before Nov 14, 2008 this sequence version replaced
            XP_001064960.1, XP_576402.2.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132261,
                              SAMD00132263 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..459
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q22"
     Protein         1..459
                     /product="zinc finger protein ZPR1"
                     /note="zinc finger protein 259"
                     /calculated_mol_wt=50723
     Region          49..206
                     /region_name="zf-ZPR1"
                     /note="ZPR1 zinc-finger domain; pfam03367"
                     /db_xref="CDD:427263"
     Region          257..416
                     /region_name="Zpr1"
                     /note="Duplicated domain in the epidermal growth factor-
                     and elongation factor-1alpha-binding protein Zpr1. Also
                     present in archaeal proteins; smart00709"
                     /db_xref="CDD:128949"
     CDS             1..459
                     /gene="Zpr1"
                     /gene_synonym="RGD1562173; Zfp259"
                     /coded_by="NM_001137646.1:34..1413"
                     /db_xref="GeneID:500989"
                     /db_xref="RGD:1562173"
ORIGIN      
        1 msasgavqpg ppgaavgpsp taaalsdtgp lfrplsaede eqqpteiesl cmncyrngtt
       61 rllltkipff reiivssfsc ehcgwnntei qsagriqdqg vrytltvkgq edmnrevvkt
      121 dsattripel dfeipafsqk galttvegli srailgleqd qptrramega iaeridefig
      181 klkdlkqmas pftliiddps gnsfvenpha pqkdsalvit yydrtpqqae mlglqaeape
      241 ekseeedlrn evlqfntncp ecnapaqtnm klvqiphfke viimatncer cghrtnevks
      301 ggaveplgtr itlhitdpsd mtrdllkset csveipelef elgmavlggk fttlegllkd
      361 irelvtknpf tlgdssnpdq seklqefsqk lgqiiegkmk ahfimndpag nsylqnvyap
      421 eddpemkver ykrsfdqnee lglndmkteg yeadlapqr
//
