LOCUS       NM_172330               1708 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Rattus norvegicus zona pellucida glycoprotein 4 (Zp4), mRNA.
ACCESSION   NM_172330
VERSION     NM_172330.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1708)
  AUTHORS   Zeng,M.H., Wang,Y., Huang,H.L., Quan,R.P., Yang,J.T., Guo,D.,
            Sun,Y., Lv,C., Li,T.Y., Wang,L., Tan,H.J., Long,P.P., Deng,H.W. and
            Xiao,H.M.
  TITLE     Zp4 is completely dispensable for fertility in female ratsdagger
  JOURNAL   Biol Reprod 104 (6), 1282-1291 (2021)
   PUBMED   33709118
  REMARK    GeneRIF: Zp4 is completely dispensable for fertility in female
            ratsdagger.
REFERENCE   2  (bases 1 to 1708)
  AUTHORS   Lv,C., Huang,H.L., Yi,D.J., Peng,T.L., Tan,H.J., Quan,R.P.,
            Deng,H.W. and Xiao,H.M.
  TITLE     Mutant Zp1 impedes incorporation of ZP3 and ZP4 in the zona
            pellucida, resulting in zona absence and female infertility in
            ratsdagger
  JOURNAL   Biol Reprod 104 (6), 1262-1270 (2021)
   PUBMED   33624742
  REMARK    GeneRIF: Mutant Zp1 impedes incorporation of ZP3 and ZP4 in the
            zona pellucida, resulting in zona absence and female infertility in
            ratsdagger.
REFERENCE   3  (bases 1 to 1708)
  AUTHORS   Dai,C., Hu,L., Gong,F., Tan,Y., Cai,S., Zhang,S., Dai,J., Lu,C.,
            Chen,J., Chen,Y., Lu,G., Du,J. and Lin,G.
  TITLE     ZP2 pathogenic variants cause in vitro fertilization failure and
            female infertility
  JOURNAL   Genet Med 21 (2), 431-440 (2019)
   PUBMED   29895852
REFERENCE   4  (bases 1 to 1708)
  AUTHORS   Louros,N.N., Chrysina,E.D., Baltatzis,G.E., Patsouris,E.S.,
            Hamodrakas,S.J. and Iconomidou,V.A.
  TITLE     A common 'aggregation-prone' interface possibly participates in the
            self-assembly of human zona pellucida proteins
  JOURNAL   FEBS Lett 590 (5), 619-630 (2016)
   PUBMED   26879157
REFERENCE   5  (bases 1 to 1708)
  AUTHORS   Jose,O., Hernandez-Hernandez,O., Chirinos,M.,
            Gonzalez-Gonzalez,M.E., Larrea,F., Almanza,A., Felix,R., Darszon,A.
            and Trevino,C.L.
  TITLE     Recombinant human ZP3-induced sperm acrosome reaction: evidence for
            the involvement of T- and L-type voltage-gated calcium channels
  JOURNAL   Biochem Biophys Res Commun 395 (4), 530-534 (2010)
   PUBMED   20394732
REFERENCE   6  (bases 1 to 1708)
  AUTHORS   Choudhury,S., Ganguly,A., Chakrabarti,K., Sharma,R.K. and
            Gupta,S.K.
  TITLE     DNA vaccine encoding chimeric protein encompassing epitopes of
            human ZP3 and ZP4: immunogenicity and characterization of
            antibodies
  JOURNAL   J Reprod Immunol 79 (2), 137-147 (2009)
   PUBMED   19004505
REFERENCE   7  (bases 1 to 1708)
  AUTHORS   Chiu,P.C., Wong,B.S., Chung,M.K., Lam,K.K., Pang,R.T., Lee,K.F.,
            Sumitro,S.B., Gupta,S.K. and Yeung,W.S.
  TITLE     Effects of native human zona pellucida glycoproteins 3 and 4 on
            acrosome reaction and zona pellucida binding of human spermatozoa
  JOURNAL   Biol Reprod 79 (5), 869-877 (2008)
   PUBMED   18667750
REFERENCE   8  (bases 1 to 1708)
  AUTHORS   Furlong,L.I., Harris,J.D. and Vazquez-Levin,M.H.
  TITLE     Binding of recombinant human proacrosin/acrosin to zona pellucida
            (ZP) glycoproteins. I. Studies with recombinant human ZPA, ZPB, and
            ZPC
  JOURNAL   Fertil Steril 83 (6), 1780-1790 (2005)
   PUBMED   15950651
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000017.1.
            
            On Sep 13, 2012 this sequence version replaced NM_172330.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF456325.1, SRR26643429.52747.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: downstream AUG is associated
                                                with N-terminal localization
                                                signal
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-215               JAXUCZ010000017.1  63703486-63703700   c
            216-337             JAXUCZ010000017.1  63703124-63703245   c
            338-446             JAXUCZ010000017.1  63702943-63703051   c
            447-605             JAXUCZ010000017.1  63701970-63702128   c
            606-796             JAXUCZ010000017.1  63701183-63701373   c
            797-894             JAXUCZ010000017.1  63700686-63700783   c
            895-1025            JAXUCZ010000017.1  63699808-63699938   c
            1026-1215           JAXUCZ010000017.1  63699339-63699528   c
            1216-1363           JAXUCZ010000017.1  63699113-63699260   c
            1364-1442           JAXUCZ010000017.1  63698754-63698832   c
            1443-1556           JAXUCZ010000017.1  63697602-63697715   c
            1557-1708           JAXUCZ010000017.1  63697147-63697298   c
FEATURES             Location/Qualifiers
     source          1..1708
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17q12.1"
     gene            1..1708
                     /gene="Zp4"
                     /gene_synonym="Zp-4"
                     /note="zona pellucida glycoprotein 4"
                     /db_xref="GeneID:282833"
                     /db_xref="RGD:628708"
     exon            1..215
                     /gene="Zp4"
                     /gene_synonym="Zp-4"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..1663
                     /gene="Zp4"
                     /gene_synonym="Zp-4"
                     /note="zona pellucida sperm-binding protein 4; zona
                     pellucida protein B; zona pellucida 4; zona pellucida B
                     glycoprotein"
                     /codon_start=1
                     /product="zona pellucida sperm-binding protein 4
                     precursor"
                     /protein_id="NP_758833.2"
                     /db_xref="GeneID:282833"
                     /db_xref="RGD:628708"
                     /translation="MARQALRSTLWLLPSILLCFPFCLPLSGQHVTELPGVLHCGLQS
                     FQFAVNLSLEAESPVLTTWDSQGLPHRLKNDSDCGTWVMDSPDGFLVLEASYSGCYVT
                     LEGSHYIMTVGVQEADVAGHVAGTRQRLLTCPLALQGKAPDTPSAKVCSPVPVKERLP
                     CASSTISRGDCEELGCCYSSEEEGADSCYYGNTVTSHCTKEGHFSIAVSRDVTSPPLR
                     LDSLRLGFRNITTGCDPVMKTSTFVLFQFPLTSCGTTQRITGDQAMYENELVAIRDVQ
                     AWGRSSITRDSNFRLRVSCTYSIHSIMSPVNMQVWTLPPPLPKTQPGPLSLELQIAQD
                     KNYSSYYGTDAYPLVKFLQDPIYVEVSILHRTDPSLSLLLEQCWATPGSNPFHQPQWP
                     ILVKGCPYAGDNYQTKRIPVQKASDVFPSHHQRFSISTFSFMSAGREKQVLGGQVYLH
                     CSASVCQPAGMPSCTVICPASRRRRKSELYFDNSTSISSKGPVILLQATKDPAVMLHK
                     HSGTHADSPTLWVMGLSASMVITGVLVVSYLATRKQR"
     exon            216..337
                     /gene="Zp4"
                     /gene_synonym="Zp-4"
                     /inference="alignment:Splign:2.1.0"
     exon            338..446
                     /gene="Zp4"
                     /gene_synonym="Zp-4"
                     /inference="alignment:Splign:2.1.0"
     exon            447..605
                     /gene="Zp4"
                     /gene_synonym="Zp-4"
                     /inference="alignment:Splign:2.1.0"
     exon            606..796
                     /gene="Zp4"
                     /gene_synonym="Zp-4"
                     /inference="alignment:Splign:2.1.0"
     exon            797..894
                     /gene="Zp4"
                     /gene_synonym="Zp-4"
                     /inference="alignment:Splign:2.1.0"
     exon            895..1025
                     /gene="Zp4"
                     /gene_synonym="Zp-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1215
                     /gene="Zp4"
                     /gene_synonym="Zp-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1216..1363
                     /gene="Zp4"
                     /gene_synonym="Zp-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1364..1442
                     /gene="Zp4"
                     /gene_synonym="Zp-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1443..1556
                     /gene="Zp4"
                     /gene_synonym="Zp-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1557..1708
                     /gene="Zp4"
                     /gene_synonym="Zp-4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gatgtgggtt agtgaaggag aaaggatggc taggcaggct ctaaggagca ctctgtggct
       61 tctaccaagc atcttactgt gtttcccatt ctgtcttcct ttgagtggcc agcatgttac
      121 cgagttgcca ggtgtgctcc actgtgggtt acagagcttc cagtttgctg tgaacctcag
      181 cctggaggca gagagtcctg tgctaacaac ttgggatagc caagggctgc cacacaggct
      241 taagaatgac tctgactgtg gtacatgggt gatggacagt cctgatggct ttctggtctt
      301 ggaagccagc tacagtggct gctatgtcac tctggaggga tcccactaca tcatgaccgt
      361 tggtgtgcaa gaggcagatg tagctggaca tgtagcagga acaagacaaa gactgcttac
      421 gtgccctttg gctcttcagg gtaaagcccc agatacacca agtgctaaag tgtgcagtcc
      481 tgtgccagta aaggaaaggc tgccctgtgc ttcctcgacc atctccagag gagactgtga
      541 agagttgggg tgctgctaca gctctgaaga ggaaggggca gactcctgtt actatggaaa
      601 cacagtgacc tcccattgca ccaaggaggg ccacttttcc attgctgtgt ccagggacgt
      661 gacctcgccc cctctgcgct tggattcact tcgcttaggc ttcaggaaca tcaccacagg
      721 gtgtgatcct gtgatgaaaa catccacctt tgtcctgttc caatttccac ttacttcctg
      781 tgggactaca cagcggatca ctggagacca ggccatgtat gaaaatgagc tagtggccat
      841 tcgggatgta caagcatggg gcagaagctc tattactaga gacagcaact tcaggctccg
      901 agtcagctgc acgtactcca ttcacagcat catgtcccca gttaacatgc aagtgtggac
      961 tctcccacca ccccttccta agacccagcc cggacccctc tctctggaac ttcagattgc
     1021 ccaggataaa aactacagct cttactacgg tactgatgcc tacccactgg taaaattcct
     1081 ccaggatccc atttacgtgg aggtctccat ccttcataga acagacccct cgttgagcct
     1141 gctgctagag caatgttggg ctacacctgg ctctaatcct tttcatcaac cacaatggcc
     1201 aatcctagtg aagggatgcc catatgctgg agacaattat cagaccaaaa ggatcccggt
     1261 tcagaaagca tcagatgtct ttccatctca tcatcagcgc ttcagtatct ctaccttcag
     1321 cttcatgagt gctggaaggg agaagcaggt tttgggtgga caggtatacc tgcactgcag
     1381 tgcatcggtc tgccagcctg ctgggatgcc atcctgcacg gttatctgtc ctgcttccag
     1441 gagaagaaga aaatctgagc tttattttga taactccacc agcatatcta gcaaaggtcc
     1501 cgtgatcctc ctccaagcca ctaaggaccc tgcagtcatg cttcataaac actcaggcac
     1561 ccatgcagat tctcccactc tgtgggtaat gggactttct gcaagcatgg tcatcactgg
     1621 agtcttggta gtatcctact tggccaccag gaaacagaga tgaatagccc aagccaagag
     1681 tctcaataaa actgactata ctaccagc
//
