LOCUS       NM_053762               1320 bp    mRNA    linear   ROD 11-DEC-2024
DEFINITION  Rattus norvegicus zona pellucida glycoprotein 3 (Zp3), mRNA.
ACCESSION   NM_053762 XM_346429
VERSION     NM_053762.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1320)
  AUTHORS   Lv,C., Huang,H.L., Yi,D.J., Peng,T.L., Tan,H.J., Quan,R.P.,
            Deng,H.W. and Xiao,H.M.
  TITLE     Mutant Zp1 impedes incorporation of ZP3 and ZP4 in the zona
            pellucida, resulting in zona absence and female infertility in
            ratsdagger
  JOURNAL   Biol Reprod 104 (6), 1262-1270 (2021)
   PUBMED   33624742
  REMARK    GeneRIF: Mutant Zp1 impedes incorporation of ZP3 and ZP4 in the
            zona pellucida, resulting in zona absence and female infertility in
            ratsdagger.
REFERENCE   2  (bases 1 to 1320)
  AUTHORS   Dai,C., Hu,L., Gong,F., Tan,Y., Cai,S., Zhang,S., Dai,J., Lu,C.,
            Chen,J., Chen,Y., Lu,G., Du,J. and Lin,G.
  TITLE     ZP2 pathogenic variants cause in vitro fertilization failure and
            female infertility
  JOURNAL   Genet Med 21 (2), 431-440 (2019)
   PUBMED   29895852
REFERENCE   3  (bases 1 to 1320)
  AUTHORS   Chen,T., Bian,Y., Liu,X., Zhao,S., Wu,K., Yan,L., Li,M., Yang,Z.,
            Liu,H., Zhao,H. and Chen,Z.J.
  TITLE     A Recurrent Missense Mutation in ZP3 Causes Empty Follicle Syndrome
            and Female Infertility
  JOURNAL   Am J Hum Genet 101 (3), 459-465 (2017)
   PUBMED   28886344
REFERENCE   4  (bases 1 to 1320)
  AUTHORS   Louros,N.N., Chrysina,E.D., Baltatzis,G.E., Patsouris,E.S.,
            Hamodrakas,S.J. and Iconomidou,V.A.
  TITLE     A common 'aggregation-prone' interface possibly participates in the
            self-assembly of human zona pellucida proteins
  JOURNAL   FEBS Lett 590 (5), 619-630 (2016)
   PUBMED   26879157
REFERENCE   5  (bases 1 to 1320)
  AUTHORS   Jose,O., Hernandez-Hernandez,O., Chirinos,M.,
            Gonzalez-Gonzalez,M.E., Larrea,F., Almanza,A., Felix,R., Darszon,A.
            and Trevino,C.L.
  TITLE     Recombinant human ZP3-induced sperm acrosome reaction: evidence for
            the involvement of T- and L-type voltage-gated calcium channels
  JOURNAL   Biochem Biophys Res Commun 395 (4), 530-534 (2010)
   PUBMED   20394732
REFERENCE   6  (bases 1 to 1320)
  AUTHORS   Cohen,N. and Wassarman,P.M.
  TITLE     Association of egg zona pellucida glycoprotein mZP3 with sperm
            protein sp56 during fertilization in mice
  JOURNAL   Int J Dev Biol 45 (3), 569-576 (2001)
   PUBMED   11417900
REFERENCE   7  (bases 1 to 1320)
  AUTHORS   O'Toole,C.M., Arnoult,C., Darszon,A., Steinhardt,R.A. and
            Florman,H.M.
  TITLE     Ca(2+) entry through store-operated channels in mouse sperm is
            initiated by egg ZP3 and drives the acrosome reaction
  JOURNAL   Mol Biol Cell 11 (5), 1571-1584 (2000)
   PUBMED   10793136
REFERENCE   8  (bases 1 to 1320)
  AUTHORS   Akatsuka,K., Yoshida-Komiya,H., Tulsiani,D.R., Orgebin-Crist,M.C.,
            Hiroi,M. and Araki,Y.
  TITLE     Rat zona pellucida glycoproteins: molecular cloning and
            characterization of the three major components
  JOURNAL   Mol Reprod Dev 51 (4), 454-467 (1998)
   PUBMED   9820205
REFERENCE   9  (bases 1 to 1320)
  AUTHORS   Rankin,T.L., Tong,Z.B., Castle,P.E., Lee,E., Gore-Langton,R.,
            Nelson,L.M. and Dean,J.
  TITLE     Human ZP3 restores fertility in Zp3 null mice without affecting
            order-specific sperm binding
  JOURNAL   Development 125 (13), 2415-2424 (1998)
   PUBMED   9609824
REFERENCE   10 (bases 1 to 1320)
  AUTHORS   Lu,Q. and Shur,B.D.
  TITLE     Sperm from beta 1,4-galactosyltransferase-null mice are refractory
            to ZP3-induced acrosome reactions and penetrate the zona pellucida
            poorly
  JOURNAL   Development 124 (20), 4121-4131 (1997)
   PUBMED   9374408
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from D78482.1.
            
            On Dec 17, 2003 this sequence version replaced XM_346429.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D78482.1, BC127488.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132271,
                                           SAMD00132281 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1320
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q12"
     gene            1..1320
                     /gene="Zp3"
                     /gene_synonym="Zp-3"
                     /note="zona pellucida glycoprotein 3"
                     /db_xref="GeneID:114639"
                     /db_xref="RGD:620606"
     exon            1..338
                     /gene="Zp3"
                     /gene_synonym="Zp-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..1304
                     /gene="Zp3"
                     /gene_synonym="Zp-3"
                     /note="zona pellucida sperm-binding protein 3; zona
                     pellucida protein C; zona pellucida glycoprotein 3 (sperm
                     receptor); zona pellucida glycoprotein ZP3"
                     /codon_start=1
                     /product="zona pellucida sperm-binding protein 3
                     precursor"
                     /protein_id="NP_446214.1"
                     /db_xref="GeneID:114639"
                     /db_xref="RGD:620606"
                     /translation="MGPSCLLFLCLLLCGGPELCYPQTQWLLPGGTPTPAGSSSPVEV
                     ECKEAELVVTARRDLFGTGKLVQPGDLTLGSEGCQPLVAVDTDVVRLNAQLHECSSGV
                     QVTEDALVYSTFLLHDPRPVNGLSILRTNRVEVPIECRYPRQGNVSSHPIQPTWVPFS
                     ATVSSEEKLAFSLRLMEEDWNTEKSSPTFHLGEVAHLQAEVQTGSHLPLQLFVDHCVA
                     TPSPLPGQNSSPHHFIVDSHGCLVDGLSESFSAFQVPRPRPETLQFTVDVFHFANSSR
                     NTVYITCHLKVAPANQIPDKLNKACSFNKTSQSWLPVEGDADICDCCSNGNCSNSSSS
                     EFETHEPAQWSTLVSRNRRHVTDEADVTVGPLIFLGKANDQAVEGWTSSAQTSVALGL
                     GLATVAFLTLAAIVLGVTRMCHTSSYLVSLPQ"
     exon            339..457
                     /gene="Zp3"
                     /gene_synonym="Zp-3"
                     /inference="alignment:Splign:2.1.0"
     exon            458..561
                     /gene="Zp3"
                     /gene_synonym="Zp-3"
                     /inference="alignment:Splign:2.1.0"
     exon            562..745
                     /gene="Zp3"
                     /gene_synonym="Zp-3"
                     /inference="alignment:Splign:2.1.0"
     exon            746..863
                     /gene="Zp3"
                     /gene_synonym="Zp-3"
                     /inference="alignment:Splign:2.1.0"
     exon            864..955
                     /gene="Zp3"
                     /gene_synonym="Zp-3"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1092
                     /gene="Zp3"
                     /gene_synonym="Zp-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1320
                     /gene="Zp3"
                     /gene_synonym="Zp-3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgcgcccgg ctgcatccca gggagcacca tggggcccag ctgtctactc ttcctgtgtc
       61 tcctgctgtg cggaggccca gaactgtgct atccccagac tcaatggctt ttaccgggtg
      121 gaacccccac cccagcgggg tcctcatcac ctgtggaggt ggagtgtaag gaagctgagc
      181 tagtggtgac tgcccgtaga gacctttttg gcacagggaa gctcgtgcag cccggggacc
      241 tcacccttgg ctcagaaggc tgtcagcccc tcgtagcagt ggatactgac gtagtcaggc
      301 tcaacgccca gttgcatgaa tgcagcagcg gggtgcaggt gacagaagac gccctggtgt
      361 acagcacctt tctgctccac gaccctcgcc ctgtgaatgg cctgtctatc ctaaggacta
      421 accgggtgga ggtccccatt gagtgccgat accccaggca gggcaatgtg agcagccacc
      481 ctatccaacc cacctgggtt cccttcagcg ctactgtgtc ctcggaggag aaactggctt
      541 tctctcttcg tctgatggag gaggactgga atactgagaa atcatctccc accttccacc
      601 tgggagaggt agcccacctc caggcggaag tccagaccgg aagccacctg cctctgcagt
      661 tgtttgtgga ccactgcgtg gccacgcctt caccgttgcc aggccagaac tcctcccccc
      721 atcacttcat cgtggactcc catggatgcc ttgtggacgg tctatctgag agcttttcag
      781 catttcaagt ccctagaccc cggccagaga ctctgcagtt cacagtggac gtattccatt
      841 tcgccaacag ctccagaaat acggtttaca tcacctgcca tctcaaagtc gctccagcta
      901 accagatccc cgataagctc aacaaagcct gttccttcaa caagacttcc cagagttggt
      961 tgccagtaga gggcgatgct gacatctgtg attgctgcag caatggcaac tgtagtaatt
     1021 caagctcttc agagttcgag acccatgaac cagcccagtg gtccacgcta gtttctcgaa
     1081 accgcaggca cgtgacggat gaagctgatg tcactgtagg gcccctgata ttccttggaa
     1141 aagcaaatga ccaggctgtg gagggctgga cctcttctgc tcaaacctct gtggctctcg
     1201 gcttaggctt ggccacagtg gcattcctga ccctggctgc tattgtcctt ggtgtcacca
     1261 ggatgtgtca cacctcttcc taccttgtat cccttcctca ataaaagaag ctcagttctg
//
