LOCUS       NM_031150               2138 bp    mRNA    linear   ROD 29-JUL-2024
DEFINITION  Rattus norvegicus zona pellucida glycoprotein 2 (Zp2), mRNA.
ACCESSION   NM_031150
VERSION     NM_031150.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2138)
  AUTHORS   Dai,C., Hu,L., Gong,F., Tan,Y., Cai,S., Zhang,S., Dai,J., Lu,C.,
            Chen,J., Chen,Y., Lu,G., Du,J. and Lin,G.
  TITLE     ZP2 pathogenic variants cause in vitro fertilization failure and
            female infertility
  JOURNAL   Genet Med 21 (2), 431-440 (2019)
   PUBMED   29895852
REFERENCE   2  (bases 1 to 2138)
  AUTHORS   Louros,N.N., Chrysina,E.D., Baltatzis,G.E., Patsouris,E.S.,
            Hamodrakas,S.J. and Iconomidou,V.A.
  TITLE     A common 'aggregation-prone' interface possibly participates in the
            self-assembly of human zona pellucida proteins
  JOURNAL   FEBS Lett 590 (5), 619-630 (2016)
   PUBMED   26879157
REFERENCE   3  (bases 1 to 2138)
  AUTHORS   Burkart,A.D., Xiong,B., Baibakov,B., Jimenez-Movilla,M. and Dean,J.
  TITLE     Ovastacin, a cortical granule protease, cleaves ZP2 in the zona
            pellucida to prevent polyspermy
  JOURNAL   J Cell Biol 197 (1), 37-44 (2012)
   PUBMED   22472438
REFERENCE   4  (bases 1 to 2138)
  AUTHORS   Jose,O., Hernandez-Hernandez,O., Chirinos,M.,
            Gonzalez-Gonzalez,M.E., Larrea,F., Almanza,A., Felix,R., Darszon,A.
            and Trevino,C.L.
  TITLE     Recombinant human ZP3-induced sperm acrosome reaction: evidence for
            the involvement of T- and L-type voltage-gated calcium channels
  JOURNAL   Biochem Biophys Res Commun 395 (4), 530-534 (2010)
   PUBMED   20394732
REFERENCE   5  (bases 1 to 2138)
  AUTHORS   Hoodbhoy,T., Aviles,M., Baibakov,B., Epifano,O.,
            Jimenez-Movilla,M., Gauthier,L. and Dean,J.
  TITLE     ZP2 and ZP3 traffic independently within oocytes prior to assembly
            into the extracellular zona pellucida
  JOURNAL   Mol Cell Biol 26 (21), 7991-7998 (2006)
   PUBMED   17047254
REFERENCE   6  (bases 1 to 2138)
  AUTHORS   El-Mestrah,M., Castle,P.E., Borossa,G. and Kan,F.W.
  TITLE     Subcellular distribution of ZP1, ZP2, and ZP3 glycoproteins during
            folliculogenesis and demonstration of their topographical
            disposition within the zona matrix of mouse ovarian oocytes
  JOURNAL   Biol Reprod 66 (4), 866-876 (2002)
   PUBMED   11906903
REFERENCE   7  (bases 1 to 2138)
  AUTHORS   Bray,C., Son,J.H., Kumar,P., Harris,J.D. and Meizel,S.
  TITLE     A role for the human sperm glycine receptor/Cl(-) channel in the
            acrosome reaction initiated by recombinant ZP3
  JOURNAL   Biol Reprod 66 (1), 91-97 (2002)
   PUBMED   11751269
REFERENCE   8  (bases 1 to 2138)
  AUTHORS   Howes,E., Pascall,J.C., Engel,W. and Jones,R.
  TITLE     Interactions between mouse ZP2 glycoprotein and proacrosin; a
            mechanism for secondary binding of sperm to the zona pellucida
            during fertilization
  JOURNAL   J Cell Sci 114 (Pt 22), 4127-4136 (2001)
   PUBMED   11739644
REFERENCE   9  (bases 1 to 2138)
  AUTHORS   O'Toole,C.M., Arnoult,C., Darszon,A., Steinhardt,R.A. and
            Florman,H.M.
  TITLE     Ca(2+) entry through store-operated channels in mouse sperm is
            initiated by egg ZP3 and drives the acrosome reaction
  JOURNAL   Mol Biol Cell 11 (5), 1571-1584 (2000)
   PUBMED   10793136
REFERENCE   10 (bases 1 to 2138)
  AUTHORS   Akatsuka,K., Yoshida-Komiya,H., Tulsiani,D.R., Orgebin-Crist,M.C.,
            Hiroi,M. and Araki,Y.
  TITLE     Rat zona pellucida glycoproteins: molecular cloning and
            characterization of the three major components
  JOURNAL   Mol Reprod Dev 51 (4), 454-467 (1998)
   PUBMED   9820205
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB000929.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB000929.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN06621351
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2138
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q36"
     gene            1..2138
                     /gene="Zp2"
                     /gene_synonym="Zp-2"
                     /note="zona pellucida glycoprotein 2"
                     /db_xref="GeneID:81828"
                     /db_xref="RGD:620605"
     exon            1..36
                     /gene="Zp2"
                     /gene_synonym="Zp-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             20..2107
                     /gene="Zp2"
                     /gene_synonym="Zp-2"
                     /note="zona pellucida sperm-binding protein 2; zona
                     pellucida protein A; zona pellucida glycoprotein ZP2; zona
                     pellucida 2 glycoprotein; zona pellucida glycoprotein 2
                     (sperm receptor)"
                     /codon_start=1
                     /product="zona pellucida sperm-binding protein 2
                     precursor"
                     /protein_id="NP_112412.1"
                     /db_xref="GeneID:81828"
                     /db_xref="RGD:620605"
                     /translation="MARWQRVYWLRSLFFALVTSVNSLSLPQSENPAFPGTLICDKDE
                     VRVEFSSRFDMEKWNPSLVDTFGNEISNCTYALDLEKFILKFPYETCTIKVIGGYQVN
                     IRVQDTNADVSYKDDVHHFFCPAIQAEIHEVSEIVVCMEDLISFSFPQLFSRLADENQ
                     NVSEMGWIIKIGNGTRVHTLPLKDAIVQGFNLLIDSQKITLHVPANATGVAHYVQESS
                     YLYTVQLKLLFSSPGQKITFSSQAICAPDLSVACNVTHMSLTIPEFPGKLKSVGFGQR
                     NIPEDQWHANGIDKEATNGLRLHFRKSLLKTKPSEKCPFYQFYFSSLELTFNFQGDML
                     STVIDPECHCESPVSIDELCTRDGFMDFEVYSHQTKPALNLESLLVGNSSCQPIFKVQ
                     SLGLARFHIPLNGCGTRQKFEGDKVIYENEIHALWENPPSNIIFRNSEFRMTVRCHYI
                     RDSMLLRAHIKSHSSPVASVKPGPLALVLQTYPDISYQRPYRKNEYPLVRYLRQPIYM
                     EVTVLNRNDPNIKLVLDDCWATTFEDPASVPQWQIIMDGCEYELDNYRTTFHAANSSA
                     AHSGHYQRFDVKTFAFVSESRGLSSLIYFHCSALICNQASPLCSVTCPAPLRNKREAS
                     KEGTMTVSLPGPIILLSDDSSSKGVMNPDSYEITKDIASKTLGAVAALVGSAVIIGFI
                     CYLHKKRIVRFNS"
     exon            37..125
                     /gene="Zp2"
                     /gene_synonym="Zp-2"
                     /inference="alignment:Splign:2.1.0"
     exon            126..209
                     /gene="Zp2"
                     /gene_synonym="Zp-2"
                     /inference="alignment:Splign:2.1.0"
     exon            210..304
                     /gene="Zp2"
                     /gene_synonym="Zp-2"
                     /inference="alignment:Splign:2.1.0"
     exon            305..454
                     /gene="Zp2"
                     /gene_synonym="Zp-2"
                     /inference="alignment:Splign:2.1.0"
     exon            455..499
                     /gene="Zp2"
                     /gene_synonym="Zp-2"
                     /inference="alignment:Splign:2.1.0"
     exon            500..661
                     /gene="Zp2"
                     /gene_synonym="Zp-2"
                     /inference="alignment:Splign:2.1.0"
     exon            662..758
                     /gene="Zp2"
                     /gene_synonym="Zp-2"
                     /inference="alignment:Splign:2.1.0"
     exon            759..943
                     /gene="Zp2"
                     /gene_synonym="Zp-2"
                     /inference="alignment:Splign:2.1.0"
     exon            944..1070
                     /gene="Zp2"
                     /gene_synonym="Zp-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1071..1252
                     /gene="Zp2"
                     /gene_synonym="Zp-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1253..1344
                     /gene="Zp2"
                     /gene_synonym="Zp-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1345..1469
                     /gene="Zp2"
                     /gene_synonym="Zp-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1470..1659
                     /gene="Zp2"
                     /gene_synonym="Zp-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1660..1795
                     /gene="Zp2"
                     /gene_synonym="Zp-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1796..1883
                     /gene="Zp2"
                     /gene_synonym="Zp-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1884..1961
                     /gene="Zp2"
                     /gene_synonym="Zp-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1962..2138
                     /gene="Zp2"
                     /gene_synonym="Zp-2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cctggaggta tcttccaaca tggctaggtg gcagagagtc tactggttgc gttctctctt
       61 cttcgccctt gtgacttcag taaattcatt aagccttcct cagtcagaga atcctgcctt
      121 cccaggcact ctcatttgtg ataaagatga agtgagagta gaattttcaa gcagatttga
      181 catggaaaag tggaatcctt ccttggtgga tacctttggt aatgaaattt cgaactgcac
      241 ttatgctctg gacttggaaa agtttatcct gaaattccct tacgagacct gtactataaa
      301 agtgattggt ggataccagg tgaacatcag agtgcaggac accaatgctg atgtaagcta
      361 taaagatgac gtgcatcact ttttctgccc agctattcaa gcagagattc atgaggtctc
      421 agaaattgtt gtctgcatgg aggatctcat atctttttct ttcccacaac ttttctctag
      481 gcttgctgat gaaaatcaga atgtatctga gatgggatgg attattaaga ttggcaatgg
      541 tacaagagtc cacactctgc ccctgaagga tgctatagta caaggattta atctcctgat
      601 tgacagccag aaaataaccc tccatgtgcc agccaatgct accggagtag ctcactatgt
      661 gcaagagagc agctatctct atactgtaca gctgaagctc ttgttctcaa gtcctgggca
      721 gaagatcacc ttctcttcac aagctatctg tgcaccagat ctttctgtgg cttgtaatgt
      781 gacacacatg agtcttacta taccagaatt tcctgggaag ctaaaatctg tgggctttgg
      841 acaaaggaac atccctgagg atcaatggca tgccaatgga attgacaaag aagcaacaaa
      901 tggcttgaga ctgcatttca gaaaatctct cttgaagaca aaaccctctg aaaagtgtcc
      961 attctaccag ttctacttct cttcactcga gctgaccttt aacttccaag gggacatgct
     1021 atccacagtg attgatcccg agtgccactg tgagtcaccg gtctccatag atgaactgtg
     1081 tacacgggat gggtttatgg actttgaggt ctacagccac caaacaaaac ctgcactaaa
     1141 cctggagagc ctcctggtgg gaaactcctc ctgccagcct attttcaagg ttcagtctct
     1201 ggggcttgca agatttcaca tacctctgaa tggatgtgga acacgacaga aatttgaagg
     1261 tgataaagtc atctatgaga atgaaatcca tgctctctgg gaaaatccac cgtcaaacat
     1321 tattttcaga aacagtgagt tcaggatgac cgtgagatgc cattacatca gagacagtat
     1381 gctactaagg gcccatatca aaagccattc ttctccagtg gcctctgtaa agccaggtcc
     1441 actagcgttg gtcctacaaa cctacccaga catatcctac caacggcctt ataggaagaa
     1501 tgagtaccct ctagtgaggt acctccgcca gcccatctac atggaagtga cagtcttgaa
     1561 tagaaatgat cccaacatca agctggtttt agatgactgc tgggcaacaa cttttgagga
     1621 cccagcctct gtcccccagt ggcagatcat tatggatggc tgtgaatatg aactggacaa
     1681 ttaccgcact actttccacg cagccaactc ctctgcagcc cattctggtc actaccagag
     1741 gtttgatgtg aagacttttg cctttgtgtc agagtctcgg gggctctcca gcctgatcta
     1801 cttccactgc agtgccttga tctgtaacca agcctcccct ctgtgctctg tgacttgccc
     1861 tgcaccactg aggaacaaac gagaggccag caaagaaggc acaatgacgg ttagcctccc
     1921 aggacctatt atcttgttgt cagatgactc ttcatccaaa ggtgtaatga accctgacag
     1981 ctatgagatt accaaagata ttgcttctaa aacattgggt gctgtggctg cactagtggg
     2041 ctcagcagtc atcataggtt tcatctgtta cctgcataag aaaagaattg taaggttcaa
     2101 ttcctgattg gacttttgca aataaaagag gctgcagt
//
