LOCUS       NM_053509               1947 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus zona pellucida glycoprotein 1 (Zp1), mRNA.
ACCESSION   NM_053509 XM_001074922 XM_001075428
VERSION     NM_053509.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1947)
  AUTHORS   Lv,C., Huang,H.L., Yi,D.J., Peng,T.L., Tan,H.J., Quan,R.P.,
            Deng,H.W. and Xiao,H.M.
  TITLE     Mutant Zp1 impedes incorporation of ZP3 and ZP4 in the zona
            pellucida, resulting in zona absence and female infertility in
            ratsdagger
  JOURNAL   Biol Reprod 104 (6), 1262-1270 (2021)
   PUBMED   33624742
  REMARK    GeneRIF: Mutant Zp1 impedes incorporation of ZP3 and ZP4 in the
            zona pellucida, resulting in zona absence and female infertility in
            ratsdagger.
REFERENCE   2  (bases 1 to 1947)
  AUTHORS   Dai,C., Hu,L., Gong,F., Tan,Y., Cai,S., Zhang,S., Dai,J., Lu,C.,
            Chen,J., Chen,Y., Lu,G., Du,J. and Lin,G.
  TITLE     ZP2 pathogenic variants cause in vitro fertilization failure and
            female infertility
  JOURNAL   Genet Med 21 (2), 431-440 (2019)
   PUBMED   29895852
REFERENCE   3  (bases 1 to 1947)
  AUTHORS   Boja,E.S., Hoodbhoy,T., Garfield,M. and Fales,H.M.
  TITLE     Structural conservation of mouse and rat zona pellucida
            glycoproteins. Probing the native rat zona pellucida proteome by
            mass spectrometry
  JOURNAL   Biochemistry 44 (50), 16445-16460 (2005)
   PUBMED   16342937
REFERENCE   4  (bases 1 to 1947)
  AUTHORS   El-Mestrah,M., Castle,P.E., Borossa,G. and Kan,F.W.
  TITLE     Subcellular distribution of ZP1, ZP2, and ZP3 glycoproteins during
            folliculogenesis and demonstration of their topographical
            disposition within the zona matrix of mouse ovarian oocytes
  JOURNAL   Biol Reprod 66 (4), 866-876 (2002)
   PUBMED   11906903
REFERENCE   5  (bases 1 to 1947)
  AUTHORS   Akatsuka,K., Yoshida-Komiya,H., Tulsiani,D.R., Orgebin-Crist,M.C.,
            Hiroi,M. and Araki,Y.
  TITLE     Rat zona pellucida glycoproteins: molecular cloning and
            characterization of the three major components
  JOURNAL   Mol Reprod Dev 51 (4), 454-467 (1998)
   PUBMED   9820205
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AB000928.1.
            
            On or before Oct 23, 2008 this sequence version replaced
            XM_001074922.1, XM_001075428.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB000928.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00155321,
                                           SAMEA5760383 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1947
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..1947
                     /gene="Zp1"
                     /gene_synonym="ZP1-202"
                     /note="zona pellucida glycoprotein 1"
                     /db_xref="GeneID:85271"
                     /db_xref="RGD:620604"
     exon            1..207
                     /gene="Zp1"
                     /gene_synonym="ZP1-202"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..1889
                     /gene="Zp1"
                     /gene_synonym="ZP1-202"
                     /note="zona pellucida sperm-binding protein 1; zp-1; zona
                     pellucida glycoprotein 1 (sperm receptor)"
                     /codon_start=1
                     /product="zona pellucida sperm-binding protein 1
                     precursor"
                     /protein_id="NP_445961.1"
                     /db_xref="GeneID:85271"
                     /db_xref="RGD:620604"
                     /translation="MAWGCFVVLLLLVAAPLRLGQHLHLKPGFQYSYDCGVQGMQLLV
                     FPRPNQTIQFKVLDEFGNRFEVNNCSICYHWVISEAQKPAVFSADYKGCHVLEKQDGR
                     FHLRVFIQAVLPNGRVDTAQDVTLICPKPDHILTPESYLAPPTTPQPFIPHTFALHPI
                     SGHTLAGSGHTGLTTLYPETHPTPAPPSSEPGPVGPTVPQSQWGTLGSWELTELDSIG
                     THLLQERCQVASGHIPCMVKGSSEEACQQAGCCYDNTKEMPCYYGNTVTLQCFRSGYF
                     TLVMSQETALTHGVMLDNVHLAYAPNGCPPTQKTSAFVVFHVPLTLCGTAIQVVGKQL
                     VYENQLVSNIEVQTGPQGSITRDGVFRLHVRCIFNASDFLPIRASIFSPQPPAPVTRS
                     GPLRLELRIATDKTFSSYYQGSDYPLVRLLQEPVYIEVRLLQRTDPGLALMLHQCWAT
                     PSASPFEQPQWPILSDGCPFKGDNYRTQMVAADRATLPFWSHYQRFTIATFTLLDSSS
                     QNALRGQVYFFCSASACHPVGSETCSTTCDSEIARHRRSSGHHNSTIRALDIVSSPGA
                     VGFEDAPKLEPSGSTRNSGSRPLLWVLQLLALTLVLGDGVLVGLSWAWAWA"
     exon            208..329
                     /gene="Zp1"
                     /gene_synonym="ZP1-202"
                     /inference="alignment:Splign:2.1.0"
     exon            330..687
                     /gene="Zp1"
                     /gene_synonym="ZP1-202"
                     /inference="alignment:Splign:2.1.0"
     exon            688..831
                     /gene="Zp1"
                     /gene_synonym="ZP1-202"
                     /inference="alignment:Splign:2.1.0"
     exon            832..1019
                     /gene="Zp1"
                     /gene_synonym="ZP1-202"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..1117
                     /gene="Zp1"
                     /gene_synonym="ZP1-202"
                     /inference="alignment:Splign:2.1.0"
     exon            1118..1245
                     /gene="Zp1"
                     /gene_synonym="ZP1-202"
                     /inference="alignment:Splign:2.1.0"
     exon            1246..1435
                     /gene="Zp1"
                     /gene_synonym="ZP1-202"
                     /inference="alignment:Splign:2.1.0"
     exon            1436..1580
                     /gene="Zp1"
                     /gene_synonym="ZP1-202"
                     /inference="alignment:Splign:2.1.0"
     exon            1581..1662
                     /gene="Zp1"
                     /gene_synonym="ZP1-202"
                     /inference="alignment:Splign:2.1.0"
     exon            1663..1770
                     /gene="Zp1"
                     /gene_synonym="ZP1-202"
                     /inference="alignment:Splign:2.1.0"
     exon            1771..1947
                     /gene="Zp1"
                     /gene_synonym="ZP1-202"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1925..1930
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zp1"
                     /gene_synonym="ZP1-202"
ORIGIN      
        1 gtgggtgtct gtggtgacag acaggagcct ccatcatggc ctggggttgt tttgtggtcc
       61 tgcttctgct ggtggcagct cccctgagat tgggtcagca tctgcatctc aagcctggct
      121 ttcaatacag ctatgactgt ggggtacagg gcatgcagct gctggtgttc cccaggccaa
      181 accagactat ccaattcaag gtgctggatg aatttgggaa ccggtttgag gtgaataact
      241 gctctatctg ctaccactgg gtgatcagtg aggcccagaa gcccgcagtg ttctcagctg
      301 attacaaagg ttgccacgtg ctggagaagc aggatgggcg tttccacctg agggtgttca
      361 tacaagctgt actacccaat ggccgtgtgg atacagcaca agatgtcact ctgatctgtc
      421 ccaaaccaga ccacatcttg actccagagt cctacctggc accacccacc acacctcagc
      481 cttttatacc tcatactttt gcccttcacc ccatctctgg ccacaccttg gctgggtctg
      541 gccacactgg tctcactaca ttgtacccag agacccatcc aactcccgct ccaccatcct
      601 cagaacctgg acctgttgga cccaccgtgc ctcagtccca gtggggcacc ttggggtcct
      661 gggaattgac tgagcttgat tctataggta cccatctgct ccaggagcgg tgtcaggtag
      721 cctctgggca catcccctgc atggtaaaag gtagttccga ggaagcctgt cagcaggctg
      781 gctgctgcta tgacaatacc aaagaaatgc cctgttacta tggcaacaca gtcactctcc
      841 agtgtttcag aagtggctac tttaccttgg tcatgtcgca agaaacagcc ttgacacacg
      901 gggtcatgct ggacaatgtc cacctagcct atgcccccaa cggatgcccc cctacccaga
      961 agacaagtgc ttttgtggtt ttccatgtcc ctctcaccct ctgtggaaca gcaatccagg
     1021 tggttggtaa gcagctcgtc tatgagaacc agctggtgtc taacatagag gtccaaacgg
     1081 gaccgcaggg ttccatcact cgggatggtg tcttccggct tcatgttcgc tgtatcttca
     1141 atgctagtga tttcctgccc atccgggcat ctatcttctc accacaacca cctgcccctg
     1201 tgacccggtc tggacccctg aggctggagc tgaggattgc cacggataag actttcagct
     1261 cctactacca ggggagtgac tatccccttg tgagactgct ccaggaacca gtttacatag
     1321 aggtccgtct cctgcagaga actgatcctg gtctggctct catgcttcat cagtgctggg
     1381 ccacaccctc tgccagcccc tttgagcagc cccaatggcc cattctgtca gatgggtgtc
     1441 ctttcaaggg tgacaactac agaacacaaa tggtggctgc agacagggca acgctgccct
     1501 tctggtctca ctatcagcgc ttcaccattg ccaccttcac tctccttgac tccagctccc
     1561 agaatgccct tcggggacag gtctatttct tctgtagtgc ctctgcctgc caccctgtgg
     1621 ggtccgagac gtgctctacc acatgtgatt ctgagatagc aaggcatcga cgatcctctg
     1681 gtcaccacaa tagcactatc cgggccctgg acattgtgag ctctccagga gcagtgggct
     1741 ttgaggatgc tcctaaactg gagccttcag gttccaccag gaactccggt tcaagaccct
     1801 tactctgggt gctccaactg ctggccctca ccctagtcct gggggatggt gtcttggtgg
     1861 gtctgagctg ggcctgggcc tgggcctaga agttctggga aggcaccgga aattaaatgg
     1921 gctcaataaa ccattgtttg aaaactg
//
