LOCUS       NM_001108628            5952 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus zinc and ring finger 2 (Znrf2), mRNA.
ACCESSION   NM_001108628 XM_001060895 XM_342692
VERSION     NM_001108628.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5952)
  AUTHORS   Gu,C., Yang,J., Luo,Y., Ran,D., Tan,X., Xiang,P., Fei,H., Lu,Y.,
            Guo,W., Tu,Y., Liu,X. and Wang,H.
  TITLE     ZNRF2 attenuates focal cerebral ischemia/reperfusion injury in rats
            by inhibiting mTORC1-mediated autophagy
  JOURNAL   Exp Neurol 342, 113759 (2021)
   PUBMED   33992580
  REMARK    GeneRIF: ZNRF2 attenuates focal cerebral ischemia/reperfusion
            injury in rats by inhibiting mTORC1-mediated autophagy.
REFERENCE   2  (bases 1 to 5952)
  AUTHORS   Hoxhaj,G., Najafov,A., Toth,R., Campbell,D.G., Prescott,A.R. and
            MacKintosh,C.
  TITLE     ZNRF2 is released from membranes by growth factors and, together
            with ZNRF1, regulates the Na+/K+ATPase
  JOURNAL   J Cell Sci 125 (Pt 19), 4662-4675 (2012)
   PUBMED   22797923
  REMARK    Erratum:[J Cell Sci. 2022 Mar 15;135(6):. PMID: 35267011]
REFERENCE   3  (bases 1 to 5952)
  AUTHORS   Ebstein,F., Lange,N., Urban,S., Seifert,U., Kruger,E. and
            Kloetzel,P.M.
  TITLE     Maturation of human dendritic cells is accompanied by functional
            remodelling of the ubiquitin-proteasome system
  JOURNAL   Int J Biochem Cell Biol 41 (5), 1205-1215 (2009)
   PUBMED   19028597
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Mar 8, 2021 this sequence version replaced NM_001108628.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643291.12545.1,
                                           SRR26643292.17991.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-683               JAXUCZ010000004.1  85280702-85281384
            684-779             JAXUCZ010000004.1  85327380-85327475
            780-885             JAXUCZ010000004.1  85342879-85342984
            886-967             JAXUCZ010000004.1  85349391-85349472
            968-5952            JAXUCZ010000004.1  85353099-85358083
FEATURES             Location/Qualifiers
     source          1..5952
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q24"
     gene            1..5952
                     /gene="Znrf2"
                     /gene_synonym="Znrf1"
                     /note="zinc and ring finger 2"
                     /db_xref="GeneID:362367"
                     /db_xref="RGD:1306645"
     exon            1..683
                     /gene="Znrf2"
                     /gene_synonym="Znrf1"
                     /inference="alignment:Splign:2.1.0"
     CDS             203..943
                     /gene="Znrf2"
                     /gene_synonym="Znrf1"
                     /EC_number="6.3.2.-"
                     /note="zinc and ring finger 1; zinc and ring finger 2, E3
                     ubiquitin protein ligase"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase ZNRF2"
                     /protein_id="NP_001102098.2"
                     /db_xref="GeneID:362367"
                     /db_xref="RGD:1306645"
                     /translation="MGAKQSGPAANGRTRAYSGSDLPSGTSGGGGADGARAARFAAPV
                     PGAQQPSASASTAAAAAAAAAAAAAAAASAPAAPRSRSLGGAVGSAASGRAAQSAFSI
                     PSSGGGSGGPYGSQDSVHSSPEDGVGSRDRDRPAGGGPGGPRLVIGSLPAHLSPHLFG
                     GFKCPVCSKFVPSDEMDLHLVMCLTKPRITYNEDVLSKDAGECAICLEELQQGDTIAR
                     LPCLCIYHKGCIDEWFEVNRSCPEHPSD"
     exon            684..779
                     /gene="Znrf2"
                     /gene_synonym="Znrf1"
                     /inference="alignment:Splign:2.1.0"
     exon            780..885
                     /gene="Znrf2"
                     /gene_synonym="Znrf1"
                     /inference="alignment:Splign:2.1.0"
     exon            886..967
                     /gene="Znrf2"
                     /gene_synonym="Znrf1"
                     /inference="alignment:Splign:2.1.0"
     exon            968..5952
                     /gene="Znrf2"
                     /gene_synonym="Znrf1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggggagccgg aggatggcgg cggtggcagc ggccgcccgg gaggaggcgg tgcggaggcc
       61 gcggagcgcg gtagcaagcg gtagcggccc gtcgcggcgg cccggcagcg accgcgtccg
      121 tacggctacc tgagcaccag ccgcgagctg tgtcctgcct cgctcgctcg ttcgctcgct
      181 cgcggcccgg ggcggcgcgg acatgggcgc caagcagagc ggccccgccg ccaacggccg
      241 cacccgcgcc tactcgggct cggacctgcc ctccgggacc agcggcggcg gcggggcgga
      301 cggcgctcgg gcggctcggt tcgcggcccc tgtccccggc gcgcagcagc ccagcgcctc
      361 ggccagcacg gcggcggctg ctgctgctgc ggcggcggca gcggcagcag cggcggcctc
      421 ggccccggca gcgccccgta gccgctcgct cggtggggcg gtgggcagcg cggcgagcgg
      481 ccgcgcggca cagtcggcct tcagcattcc cagcagtggc ggcggcagcg gtggcccgta
      541 cggctcacag gactcggtgc acagcagccc agaggacggt gtcggctcta gggaccggga
      601 ccggccagcg ggcgggggcc ctggcgggcc gcgtctggtg atcggctcgc tcccggccca
      661 cctctccccg cacttgtttg gaggatttaa gtgcccggta tgctcaaaat ttgtaccctc
      721 agatgaaatg gatttgcatc ttgtgatgtg tttaacaaag ccaagaataa cgtataatga
      781 ggatgtgctg agtaaagatg cgggggaatg tgcaatatgc cttgaagaat tgcagcaggg
      841 agacaccata gcacgactgc cttgcctgtg tatatatcat aaaggctgca tagatgaatg
      901 gtttgaagta aatagatctt gtccagagca cccttcggat taagcacacc agattcctgt
      961 gttatgggtt ttcttgtctt ttcaagatgc ttaagaaatc tagaagattt gaagatctgt
     1021 ctctggaaga aaatgagaac tgcaggctta ttcagccaga atctgagttc tgggacactt
     1081 gggtagtcca gagaaggaca ggaactacag aactcagcgt accaaacttg cataaaaggg
     1141 acacacaggg attttgaaaa tgctgcacat cctgtactag tcactgcata gatgacactg
     1201 ataaacattt tgtattcaga cgccaaagtt aactcatttc aaagttgatt tactttttat
     1261 taagttctgt agagctgctg ttttagtgta tttggttttg gtttgtttgt tttgtttttt
     1321 tgtttttgtt tttgtttttt tttttagttt ggggactttt tattttcccg aacataatgt
     1381 ttctgcattc acctattctt atcttgaaaa ccacacagtt tctttcttac aaactcttca
     1441 atgtgaaacc aagaaatgta atcaaagcag tataatattc tgtgaatgga gagtataatt
     1501 gaagttcttc cacacacatc cctccccccc cacccctacc ccctccctgt cccccatgtg
     1561 tggaaaagta ggtttctggg ttggagagct aaaatatgtt agtagtttga attaaaggtt
     1621 taatattata aaaatgccat ccaaagagta aatcaagtta cataattaca tttagttaat
     1681 taaatgtaga actgtctact gaactgcagt ttctgaaata cattgtttct tctaaaagga
     1741 aactgcagta gcttgttagc agtgaccatc ttgcagctat gcaactttga gaagtccata
     1801 tttgatggtc cctcctctgg ggcccagcga ctctgtccta ccaggtgtcc ttgttctttc
     1861 ctgtaattac ttcattgtgc tttgcatctc cgggcaggct ccctatgttt gggtaaaatg
     1921 tttagcaagt tgtaaacgtc ataccttatg aaaagggtga aataaacact tctgcagtgg
     1981 gacttggagt aatttgaggg acattttata tacttttaaa aatcagaatt taattgggat
     2041 gccagatttc tagcaacttg catctttagt tttccagata atctggaagt tagcatttga
     2101 taaatgattt tttaagcaaa tataaagatt ttgttaattt ataatttatt aatgtgttgt
     2161 tactgtaatt gaacatgtta tggatacttt taaattcagt ctttgtagaa agaactgtat
     2221 taagcaaaat tatgtgaata aatattcccc caaaatacat ctgatggtta agaatactgg
     2281 aagagagcta tcagggctgc aacagtgact gtctttttaa ataattatca aaatatcaag
     2341 cagtagatcc atgtttagtc tccagggaga gcattgcttc cctgatctag tcaaggctga
     2401 gcaggcctgc tctcctgctg agctgccctg gctgtggaag ggtgagagtc tccagtgctg
     2461 cttttgtact cggacttgtc cctgttgctt ctgccgcttc ctatgcccga gggcatgcat
     2521 gtgcaggagc agctgctgcc gtggtgggct tggggtaggg ttggcctgat agtggaagct
     2581 cttgctgctt tcctctggct gtagtctaga tagccctctg cagtccactg ttcgggtcag
     2641 tggtctgatc ctgtgggaca gctgccagca cagcgctgta ggtgttcttt aggaaggtta
     2701 ctcttccttc aagggaaatc gtctttcctt aaaggtttgt tttgtttttt gtttttcttt
     2761 tttctgttaa tatgaactct gaatccattt tacttcatct ttgagtttgt gagctttcct
     2821 ctcccctggt ttcccccagg gaagagctct tcaaatgtga aaaaccactc tgccctctac
     2881 tacccgtgtg ttgtctggag aagagcgact tctgcagtct gctcttcctt gagtgcagct
     2941 gtgctaatta atgtttagac tccctgcaag atgacctgcc tcgtgctaag ctcaccttct
     3001 tggagtctca gcctcagttt acccttcctt cacactgtcc tccagcggtc ttcgtggctt
     3061 ccatgctttg gctgcctcct cgctcctgtg tgtgagagag ctcagtgctg tcctggcaag
     3121 gacatggaca ctggctgtgc tgaggtctgt gcagtggttg ctgaaatcca ctcagacagc
     3181 ctactttggt tttggttttg tttggtcata ttttataaaa ttggcatttt tactttaaat
     3241 tttgtctgca gtgatttcct aaaaagaata atttagaaat agaagagaaa aagagaagct
     3301 aagatgtttc agtttctgtt cacagttact attctgggaa tgttctctaa gtgataattt
     3361 atgtaatatt gcttatacta tttatcagtc tgtatgcaga cactgagtag catccatcat
     3421 aaagttacag actattcagc tgaaactact gaatatagag acaaagtaaa aattgaaagc
     3481 ctcagttatg agttacccgg cgggtcagag ccttctataa tctttgtaaa taccctccag
     3541 tcaggtccac tctgtccata gtgagtttac tgccaatgtg aatcctattt tgatcgttgt
     3601 tttattcccg ctttgccagg atatttaaga caaagcactg ttttctttgt aaaatgattt
     3661 tctttctttg gctcctctct agagaaatat ttcaaccata gttacaaatc agactgtaag
     3721 attgttttaa gaagaaatgt ttatgattaa gatatgagca gtggtctcta cttggcttgt
     3781 gtacatgaca gtagaagtga cactgcaaaa gtcctggtga cagttggagt ttataggttt
     3841 gggctttcca gtgcaagtct ctgcactcgt aaattttaca tggttgttct agttttcact
     3901 tagatactgg actgcagtcc agaataacca aggaccatct ttagcgtatt ttcagtgttc
     3961 acagcaaaga tatttccacc tgactgagtt gccagaaatg gcaaaatctt ttccagagtg
     4021 tatttcatac tgtgtttcta agtatgggta tggtgaggtt tcagaacact catttcctac
     4081 tggacatggt gactcatgcc aacactcagg aacctgaggc agggggattg ccacaaggtc
     4141 caggctggcc tgggcaacat agtgagttct aggctagact gtctcaaaaa aaaaaaaaaa
     4201 aaaagaaaaa aagtaatcat tttactatgt tacagcaaga catattcctt ttgttgagaa
     4261 agggtgtggg ttcagtgtaa atagtgcctg ctttttctgt agtgacttag gggaagtagg
     4321 ggttctccag caggagactc aggtgagccg tgtgaaactc tacaattcag gaatgggtgg
     4381 gtctgccatc tgaccggcag ctgcactgta ctgaccgcat gatccagata gctttctcat
     4441 cccagagaag gttccaccta agccaggcca aagcgtttgg tttacagcat acagagtggc
     4501 cctgaggcaa aggcaccatg tgctgcttgc acgtctctag tgtgcttagc aatttttctg
     4561 tgggtttggt ctaccctggg gtaaactcca cactcactga cagtgagaga tgagacacgg
     4621 agggtccctt gttattcagc atacagagat tttaacttga ctttaaaatt gtaatatgtc
     4681 agtcctttgg agcccattct cctatcgttc ctagagtgta taacttctga tattttctta
     4741 gctatgtgat ataactagtt accttacctc ttttacccta ctctttctcc atcccacaac
     4801 ttgtactgag tatgaatggc tgttgcttgg agtactcctg aaatcattga taaaattgtt
     4861 ggtgataatg tacccaacca gtactttata ctatattctg taaatgcact taagctagga
     4921 aatagacttt aaaaaaaaaa aatcagagtt ctgttttaaa taggaatacc tgatttccta
     4981 agtctgttga ctttctgtga gatacaagac cttggacacc agacatgtta atgcttactt
     5041 tcagtttaac atacaccatc actgtcctca caaggttgtt ttcagatatt caaactattc
     5101 ttaatttctg agcagtgcgt gcgtgcgtgc gtgcgtgcgt gcatgtgtgt gtgtgtgtag
     5161 agaagcagag agcagtgtgg catgaactaa catctctaca tacaaaaatg acaaatgtga
     5221 tactgaagca cttactaatg tgcatttctt agctctgtcc ctggaccctg agaatctcaa
     5281 gattggatat cggaagtaac agttctctta ccaatcactg tctgcccatg cctgcctttt
     5341 ctgatttagt atgttggagt tggcatgtgc ctatcatcta tgtgggaaac ttaactgctt
     5401 gcatattgtt agcagtaact gtggtgacag aactgtttcc ttttattagt caagctcgtc
     5461 tgatagcctg cacctgagat gttgaggcag aagcagagga tcatgggttt gaaaccagtt
     5521 tgagctgcac agtgagtttg agacaagcct gaactacaac gtgagagctt gtctcgtggt
     5581 tgtagtcacg ttagagtgtt ggatgtgtgc tgtctggtta ggagactctg gtctaagaaa
     5641 caacaggaac cttggactcg atggcactaa gtaacaagtc attgtgttgc tttgtaggtg
     5701 acttgttata tcagtttctt tgcttgaaaa atcacaatat ttacctctga tttattcatg
     5761 ttttctacaa ctcttctata atacctctta atttcctcta ttagaaagta ttttgttctt
     5821 gttaaacaag gccctaaaag cattgatcat aagaaatgag aaaatgtatt aggaacagct
     5881 tgtattagtg tgttctgaac agaaacggaa caattcatca ttgatatttt aataaataaa
     5941 atttccaaat ga
//
