LOCUS       NM_001107974            2196 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus zinc metallopeptidase STE24 (Zmpste24), mRNA.
ACCESSION   NM_001107974 XM_001053840 XM_233483
VERSION     NM_001107974.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2196)
  AUTHORS   Fu B, Wang L, Li S and Dorf ME.
  TITLE     ZMPSTE24 defends against influenza and other pathogenic viruses
  JOURNAL   J Exp Med 214 (4), 919-929 (2017)
   PUBMED   28246125
REFERENCE   2  (bases 1 to 2196)
  AUTHORS   Rivera-Torres J, Calvo CJ, Llach A, Guzman-Martinez G, Caballero R,
            Gonzalez-Gomez C, Jimenez-Borreguero LJ, Guadix JA, Osorio FG,
            Lopez-Otin C, Herraiz-Martinez A, Cabello N, Vallmitjana A, Benitez
            R, Gordon LB, Jalife J, Perez-Pomares JM, Tamargo J, Delpon E,
            Hove-Madsen L, Filgueiras-Rama D and Andres V.
  TITLE     Cardiac electrical defects in progeroid mice and Hutchinson-Gilford
            progeria syndrome patients with nuclear lamina alterations
  JOURNAL   Proc Natl Acad Sci U S A 113 (46), E7250-E7259 (2016)
   PUBMED   27799555
REFERENCE   3  (bases 1 to 2196)
  AUTHORS   Wang M, Fu Y, Gao C, Jia Y, Huang Y, Liu L, Wang X, Wang W and Kong
            W.
  TITLE     Cartilage oligomeric matrix protein prevents vascular aging and
            vascular smooth muscle cells senescence
  JOURNAL   Biochem Biophys Res Commun 478 (2), 1006-1013 (2016)
   PUBMED   27498005
REFERENCE   4  (bases 1 to 2196)
  AUTHORS   Ibrahim MX, Sayin VI, Akula MK, Liu M, Fong LG, Young SG and Bergo
            MO.
  TITLE     Targeting isoprenylcysteine methylation ameliorates disease in a
            mouse model of progeria
  JOURNAL   Science 340 (6138), 1330-1333 (2013)
   PUBMED   23686339
REFERENCE   5  (bases 1 to 2196)
  AUTHORS   Liu B, Wang Z, Zhang L, Ghosh S, Zheng H and Zhou Z.
  TITLE     Depleting the methyltransferase Suv39h1 improves DNA repair and
            extends lifespan in a progeria mouse model
  JOURNAL   Nat Commun 4, 1868 (2013)
   PUBMED   23695662
REFERENCE   6  (bases 1 to 2196)
  AUTHORS   Liu B, Wang J, Chan KM, Tjia WM, Deng W, Guan X, Huang JD, Li KM,
            Chau PY, Chen DJ, Pei D, Pendas AM, Cadinanos J, Lopez-Otin C, Tse
            HF, Hutchison C, Chen J, Cao Y, Cheah KS, Tryggvason K and Zhou Z.
  TITLE     Genomic instability in laminopathy-based premature aging
  JOURNAL   Nat Med 11 (7), 780-785 (2005)
   PUBMED   15980864
REFERENCE   7  (bases 1 to 2196)
  AUTHORS   Fong LG, Ng JK, Meta M, Cote N, Yang SH, Stewart CL, Sullivan T,
            Burghardt A, Majumdar S, Reue K, Bergo MO and Young SG.
  TITLE     Heterozygosity for Lmna deficiency eliminates the progeria-like
            phenotypes in Zmpste24-deficient mice
  JOURNAL   Proc Natl Acad Sci U S A 101 (52), 18111-18116 (2004)
   PUBMED   15608054
REFERENCE   8  (bases 1 to 2196)
  AUTHORS   Agarwal AK, Fryns JP, Auchus RJ and Garg A.
  TITLE     Zinc metalloproteinase, ZMPSTE24, is mutated in mandibuloacral
            dysplasia
  JOURNAL   Hum Mol Genet 12 (16), 1995-2001 (2003)
   PUBMED   12913070
REFERENCE   9  (bases 1 to 2196)
  AUTHORS   Pendas AM, Zhou Z, Cadinanos J, Freije JM, Wang J, Hultenby K,
            Astudillo A, Wernerson A, Rodriguez F, Tryggvason K and Lopez-Otin
            C.
  TITLE     Defective prelamin A processing and muscular and adipocyte
            alterations in Zmpste24 metalloproteinase-deficient mice
  JOURNAL   Nat Genet 31 (1), 94-99 (2002)
   PUBMED   11923874
REFERENCE   10 (bases 1 to 2196)
  AUTHORS   Leung GK, Schmidt WK, Bergo MO, Gavino B, Wong DH, Tam A, Ashby MN,
            Michaelis S and Young SG.
  TITLE     Biochemical studies of Zmpste24-deficient mice
  JOURNAL   J Biol Chem 276 (31), 29051-29058 (2001)
   PUBMED   11399759
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473968.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001053840.1, XM_233483.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760494
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2196
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..2196
                     /gene="Zmpste24"
                     /note="zinc metallopeptidase STE24"
                     /db_xref="GeneID:313564"
                     /db_xref="RGD:1305570"
     exon            1..444
                     /gene="Zmpste24"
                     /inference="alignment:Splign:2.1.0"
     CDS             322..1749
                     /gene="Zmpste24"
                     /EC_number="3.4.24.84"
                     /note="zinc metalloproteinase, STE24 homolog; zinc
                     metallopeptidase, STE24 homolog"
                     /codon_start=1
                     /product="CAAX prenyl protease 1 homolog"
                     /protein_id="NP_001101444.1"
                     /db_xref="GeneID:313564"
                     /db_xref="RGD:1305570"
                     /translation="MGMWASVDAMWDFPAEKRIFGAVLLFSWTVYLWETFLAQRQRRI
                     YKTTTHVPPELEQIMDSDTFEKSRLYQLDKSTFSFWSGLYSEVEGTFILLFGGIPYLW
                     RLSGRFCSSAGFGPEYEIIQSLVFLLLATLFSALTGLPWSLYNTFVIEEKHGFNHQTL
                     EFFMKDAIKKFIVTQCILLPVSSLLLYIIKIGGDYFFIYAWLFTLVVSLVLVTIYADY
                     IAPLFDKFTPLPEGKLKQEIEVMAKSIDFPLTKVYVVEGSKRSSHSNAYFYGFFKNKR
                     IVLFDTLLEEYSVPNKDNQEEPGLEPRNEGEGDSEEVKSKVKNKKQGCKNEEVLAVLG
                     HELGHWKLGHTVKNIIISQMNSFLCFFLFAVLIGRRELFAAFGFYDSQPTLIGLLIIF
                     QFIFSPYNEVLSFCLTVLSRRFEFQADAFAKKLGKAKDLYSALIKLNKDNLGFPVSDW
                     LFSTWHYSHPPLLERLQALKNAKRD"
     exon            445..591
                     /gene="Zmpste24"
                     /inference="alignment:Splign:2.1.0"
     exon            592..678
                     /gene="Zmpste24"
                     /inference="alignment:Splign:2.1.0"
     exon            679..795
                     /gene="Zmpste24"
                     /inference="alignment:Splign:2.1.0"
     exon            796..948
                     /gene="Zmpste24"
                     /inference="alignment:Splign:2.1.0"
     exon            949..1090
                     /gene="Zmpste24"
                     /inference="alignment:Splign:2.1.0"
     exon            1091..1275
                     /gene="Zmpste24"
                     /inference="alignment:Splign:2.1.0"
     exon            1276..1380
                     /gene="Zmpste24"
                     /inference="alignment:Splign:2.1.0"
     exon            1381..1524
                     /gene="Zmpste24"
                     /inference="alignment:Splign:2.1.0"
     exon            1525..2196
                     /gene="Zmpste24"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccaggaaga agtcccggaa cctttgagtt tgagtcccgc gcgcagaatc cggagtgatg
       61 tttcaggtgc accgccgctc agtcttcggg ccggaaatgg gaaaggtggg gcaagtctta
      121 ttctagcaga atatataggt ccttgagaag ccggaggggg aagagtgtct ttgtgacact
      181 gctggcaaag ctaaggggat gggcgtctga agaagccttc ggaaaggacc cgtatcgtgg
      241 tgacaccact ggcactttct gagggacgcg tgtcggtgtg gcaccggtgc tagccgaagg
      301 agcgggtcag attgggtgac catggggatg tgggcatcgg tggacgctat gtgggacttc
      361 cctgcggaga agcgaatctt cggggcggtg ttgctctttt cctggaccgt gtatctttgg
      421 gagaccttcc tagcacagcg gcagagaagg atatacaaaa caacgactca tgtaccacca
      481 gagttagaac agatcatgga ttcggacaca tttgagaaat cacgactgta tcaactggat
      541 aaaagtacat tcagcttctg gtcaggactc tattcagagg tggaaggcac ttttattctt
      601 ctctttggag gaatccctta cctctggaga ctttctggac ggttctgtag ttctgctggc
      661 ttcggaccag aatatgagat cattcagtcg ttggtgttcc tgctgttggc tacactcttc
      721 agtgcactga ctggcttgcc atggagtctg tacaatactt tcgtgataga agaaaagcat
      781 ggcttcaatc accagacttt ggagtttttt atgaaagatg caatcaaaaa atttattgtg
      841 actcagtgta ttttattgcc tgtgtcttcc cttctgcttt acattattaa aatcggaggt
      901 gactactttt ttatctatgc ctggctgttc acattagttg tttctctggt tcttgtcaca
      961 atttatgctg attatattgc ccctttgttt gacaagttca cacctctacc ggaggggaaa
     1021 cttaagcagg aaatcgaagt gatggcgaag agtattgact tccccctgac taaggtgtat
     1081 gtcgttgaag gatctaagcg ctcctcccac agcaatgctt acttttatgg cttcttcaag
     1141 aacaagagaa tagttttgtt tgacactcta ctagaagagt actctgtacc aaacaaagac
     1201 aaccaggagg agcctggcct ggagccccgc aatgaaggcg aaggggacag tgaagaagta
     1261 aagtctaaag tgaaaaataa gaaacaagga tgtaaaaatg aggaggtact agctgtactt
     1321 ggccatgaac tggggcactg gaagttggga cacacagtaa aaaatatcat tattagtcag
     1381 atgaattctt tcctgtgttt tttcttgttt gctgtattaa ttggtcgaag ggaacttttt
     1441 gccgcctttg gtttttatga cagccaaccc actctgatcg gacttttgat catctttcag
     1501 tttattttct caccttacaa tgaggttctg tctttctgcc taacagtcct gagccgcaga
     1561 tttgaatttc aagccgacgc ttttgccaag aaacttggga aggctaaaga cttatattct
     1621 gctttgatca agctaaacaa agataacctg ggcttcccag tctctgactg gctgttctca
     1681 acatggcact attctcaccc tccgcttctg gagaggcttc aggctctgaa aaatgcaaaa
     1741 cgagactgag ccgctcaggc cccatgactg gacacacttc tggttatttc tgtcctggca
     1801 gcatgttcca gctcttgatg tttttaattt tttaagaaaa atgattacgt acataaaggt
     1861 ccagatttaa atacatttac tatctcattt caaaaatgat tttaataatc catttcttaa
     1921 aacactggat aaaattttga ggcttaatat ttttaaagca tagttttatc tagcatctga
     1981 tttgccatca atttgtaaat gatttaagga aatgcacaac ttgtttgatt tctgcactat
     2041 gtggaatctg cgtagagggt ttttaggtcg tacgtttaaa ggtggaaaca ccgcctccaa
     2101 gcactttctg cggggcagaa acaaaaagtg gtcccagatc actgtgcttg tgcctacaca
     2161 ggcttcgctt ttaccgtcac gctgttatga tttaac
//
