LOCUS       NP_001101863            1072 aa            linear   ROD 07-JAN-2025
DEFINITION  zinc finger MIZ domain-containing protein 1 [Rattus norvegicus].
ACCESSION   NP_001101863 XP_001054961 XP_341390
VERSION     NP_001101863.1
DBSOURCE    REFSEQ: accession NM_001108393.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 1072)
  AUTHORS   Carapito,R., Ivanova,E.L., Morlon,A., Meng,L., Molitor,A.,
            Erdmann,E., Kieffer,B., Pichot,A., Naegely,L., Kolmer,A., Paul,N.,
            Hanauer,A., Tran Mau-Them,F., Jean-Marcais,N., Hiatt,S.M.,
            Cooper,G.M., Tvrdik,T., Muir,A.M., Dimartino,C., Chopra,M.,
            Amiel,J., Gordon,C.T., Dutreux,F., Garde,A., Thauvin-Robinet,C.,
            Wang,X., Leduc,M.S., Phillips,M., Crawford,H.P., Kukolich,M.K.,
            Hunt,D., Harrison,V., Kharbanda,M., Smigiel,R., Gold,N., Hung,C.Y.,
            Viskochil,D.H., Dugan,S.L., Bayrak-Toydemir,P., Joly-Helas,G.,
            Guerrot,A.M., Schluth-Bolard,C., Rio,M., Wentzensen,I.M.,
            McWalter,K., Schnur,R.E., Lewis,A.M., Lalani,S.R., Mensah-Bonsu,N.,
            Ceraline,J., Sun,Z., Ploski,R., Bacino,C.A., Mefford,H.C.,
            Faivre,L., Bodamer,O., Chelly,J., Isidor,B. and Bahram,S.
  CONSRTM   Deciphering Developmental Disorders Study; University of Washington
            Center for Mendelian Genomics
  TITLE     ZMIZ1 Variants Cause a Syndromic Neurodevelopmental Disorder
  JOURNAL   Am J Hum Genet 104 (2), 319-330 (2019)
   PUBMED   30639322
  REMARK    Erratum:[Am J Hum Genet. 2020 Jan 2;106(1):137. doi:
            10.1016/j.ajhg.2019.11.014. PMID: 31879022]
REFERENCE   2  (residues 1 to 1072)
  AUTHORS   Pinnell,N., Yan,R., Cho,H.J., Keeley,T., Murai,M.J., Liu,Y.,
            Alarcon,A.S., Qin,J., Wang,Q., Kuick,R., Elenitoba-Johnson,K.S.,
            Maillard,I., Samuelson,L.C., Cierpicki,T. and Chiang,M.Y.
  TITLE     The PIAS-like Coactivator Zmiz1 Is a Direct and Selective Cofactor
            of Notch1 in T Cell Development and Leukemia
  JOURNAL   Immunity 43 (5), 870-883 (2015)
   PUBMED   26522984
REFERENCE   3  (residues 1 to 1072)
  AUTHORS   Craig,D.W., Millis,M.P. and DiStefano,J.K.
  TITLE     Genome-wide SNP genotyping study using pooled DNA to identify
            candidate markers mediating susceptibility to end-stage renal
            disease attributed to Type 1 diabetes
  JOURNAL   Diabet Med 26 (11), 1090-1098 (2009)
   PUBMED   19929986
REFERENCE   4  (residues 1 to 1072)
  AUTHORS   Beliakoff,J., Lee,J., Ueno,H., Aiyer,A., Weissman,I.L., Barsh,G.S.,
            Cardiff,R.D. and Sun,Z.
  TITLE     The PIAS-like protein Zimp10 is essential for embryonic viability
            and proper vascular development
  JOURNAL   Mol Cell Biol 28 (1), 282-292 (2008)
   PUBMED   17967885
REFERENCE   5  (residues 1 to 1072)
  AUTHORS   Li,X., Thyssen,G., Beliakoff,J. and Sun,Z.
  TITLE     The novel PIAS-like protein hZimp10 enhances Smad transcriptional
            activity
  JOURNAL   J Biol Chem 281 (33), 23748-23756 (2006)
   PUBMED   16777850
REFERENCE   6  (residues 1 to 1072)
  AUTHORS   Tarunina,M., Alger,L., Chu,G., Munger,K., Gudkov,A. and Jat,P.S.
  TITLE     Functional genetic screen for genes involved in senescence: role of
            Tid1, a homologue of the Drosophila tumor suppressor l(2)tid, in
            senescence and cell survival
  JOURNAL   Mol Cell Biol 24 (24), 10792-10801 (2004)
   PUBMED   15572682
REFERENCE   7  (residues 1 to 1072)
  AUTHORS   Sharma,M., Li,X., Wang,Y., Zarnegar,M., Huang,C.Y., Palvimo,J.J.,
            Lim,B. and Sun,Z.
  TITLE     hZimp10 is an androgen receptor co-activator and forms a complex
            with SUMO-1 at replication foci
  JOURNAL   EMBO J 22 (22), 6101-6114 (2003)
   PUBMED   14609956
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474067.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XP_341390.2, XP_001054961.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132261,
                              SAMD00132262 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1072
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p16"
     Protein         1..1072
                     /product="zinc finger MIZ domain-containing protein 1"
                     /note="retinoic acid induced 17"
                     /calculated_mol_wt=115762
     Region          8..100
                     /region_name="Zmiz1_N"
                     /note="Zmiz1 N-terminal tetratricopeptide repeat domain;
                     pfam18028"
                     /db_xref="CDD:375500"
     Region          <183..562
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          744..807
                     /region_name="RING_Ubox"
                     /note="RING finger (Really Interesting New Gene) domain
                     and U-box domain superfamily; cl17238"
                     /db_xref="CDD:473075"
     Site            order(749,752,765,767,772,775,788,791)
                     /site_type="other"
                     /note="cross-brace motif"
                     /db_xref="CDD:438111"
     CDS             1..1072
                     /gene="Zmiz1"
                     /gene_synonym="Rai17"
                     /coded_by="NM_001108393.1:581..3799"
                     /db_xref="GeneID:361103"
                     /db_xref="RGD:1311620"
ORIGIN      
        1 mnsmdrhiqq tndrlqcikq hlqnpanfhn aatelldwcg dprafqrpfe qslmgcltvv
       61 srvaaqqgfd ldlgyrllav caanrdkftp ksaallsswc eelgrllllr hqksrqndpp
      121 gklpmqppln smssmkptls hsdgsfpyds vpwqqntnqp pgslsvvttv wgvtntsqsq
      181 vlgnpmanas npmnpggnpm asgmstsnpg lnspqfagqq qqfstkagpa qpyiqpnmyg
      241 rpgypgsggf gasypggpsa pagmgippht rppadftqpa aaaaaaavaa aaatatatat
      301 atvaalqetq nkdinqygpv cssfqmgptq aynsqfmnqp gprgpasmgg smnpasmaag
      361 mtpsgmsgpp mgmnqprppg ispfgthgqr mpqqtypgpr pqslpiqsik rsypgepnyg
      421 nqqygpnsqf ptqpgqyptp npprpltspn ypgqrmpsqp stgqyppptv nmgqyykpeq
      481 fngqnntfss gssyssysqg svnrpprpvp vanyphspvp gnptppmtpg ssippylsps
      541 qdvkppfppd ikpnmsalpp ppanhndelr ltfpvrdgvv lepfrlehnl avsnhvfhlr
      601 ptvhqtlmwr sdlelqfkcy hhedrqmntn wpasvqvsvn atpltiergd nktshkplhl
      661 khvcqpgrnt iqitvtaccc shlfvlqlvh rpsvrsvlqg llkkrllpae hcitkikrnf
      721 ssvaassgnt tlngedgveq taikvslkcp itfrriqlpa rghdckhvqc fdlesylqln
      781 cergtwrcpv cnktallegl evdqymwgil naiqhsefee vtidptcswr pvpiksdlhi
      841 kddpdgipsk rfktmspsqm impnvmemia algpgpspyp lppppggtss ndyssqgsny
      901 qghgnfdfph gnpggtsmnd fmhgppqlsh ppdmpnnmaa lekplshpmq etmphagssd
      961 qphpsiqqgl hvphpssqag pplhhsgapp psqpprqppq aapsnhphsd ltfnpssale
     1021 gqagaqgasd mpepsldllp eltnpdells yldppdlpsn snddllslfe nn
//
