LOCUS       NM_022548               7422 bp    mRNA    linear   ROD 17-FEB-2024
DEFINITION  Rattus norvegicus zinc finger, matrin type 3 (Zmat3), mRNA.
ACCESSION   NM_022548 XM_346622
VERSION     NM_022548.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7422)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   2  (bases 1 to 7422)
  AUTHORS   Shimizu,M., Miyazaki,I., Higashi,Y., Eslava-Alva,M.J.,
            Diaz-Corrales,F.J., Asanuma,M. and Ogawa,N.
  TITLE     Specific induction of PAG608 in cranial and spinal motor neurons of
            L-DOPA-treated parkinsonian rats
  JOURNAL   Neurosci Res 60 (4), 355-363 (2008)
   PUBMED   18242749
  REMARK    GeneRIF: The specific induction of PAG608 6-48h after L-DOPA
            injection in the extrapyramidal tracts, pyramidal tracts and
            corresponding lower motor neurons of the spinal cords suggests its
            involvement in molecular events in stimulated motor neurons.
REFERENCE   3  (bases 1 to 7422)
  AUTHORS   Asanuma,M., Miyazaki,I., Higashi,Y., Diaz-Corrales,F.J.,
            Shimizu,M., Miyoshi,K. and Ogawa,N.
  TITLE     Suppression of p53-activated gene, PAG608, attenuates
            methamphetamine-induced neurotoxicity
  JOURNAL   Neurosci Lett 414 (3), 263-267 (2007)
   PUBMED   17234339
  REMARK    GeneRIF: Methamphetamine neurotoxicity in monoaminergic cells is
            related, at least in part, to induction of PAG608 expression.
REFERENCE   4  (bases 1 to 7422)
  AUTHORS   Higashi,Y., Asanuma,M., Miyazaki,I., Haque,M.E., Fujita,N.,
            Tanaka,K. and Ogawa,N.
  TITLE     The p53-activated gene, PAG608, requires a zinc finger domain for
            nuclear localization and oxidative stress-induced apoptosis
  JOURNAL   J Biol Chem 277 (44), 42224-42232 (2002)
   PUBMED   12196512
  REMARK    GeneRIF: PAG608 may induce or regulate p53 expression and
            translocate to the nucleus and nucleolus using its first zinc
            finger domain during oxidative stress-induced apoptosis of
            catecholamine-containing cells.
REFERENCE   5  (bases 1 to 7422)
  AUTHORS   Israeli,D., Tessler,E., Haupt,Y., Elkeles,A., Wilder,S., Amson,R.,
            Telerman,A. and Oren,M.
  TITLE     A novel p53-inducible gene, PAG608, encodes a nuclear zinc finger
            protein whose overexpression promotes apoptosis
  JOURNAL   EMBO J 16 (14), 4384-4392 (1997)
   PUBMED   9250682
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000067.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by NM_022548.3.
            
            On Feb 26, 2021 this sequence version replaced NM_022548.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR8487227.64317.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-183               JACYVU010000067.1  30204328-30204510   c
            184-514             JACYVU010000067.1  30199923-30200253   c
            515-634             JACYVU010000067.1  30184290-30184409   c
            635-801             JACYVU010000067.1  30182455-30182621   c
            802-902             JACYVU010000067.1  30182237-30182337   c
            903-7422            JACYVU010000067.1  30173668-30180187   c
FEATURES             Location/Qualifiers
     source          1..7422
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q24"
     gene            1..7422
                     /gene="Zmat3"
                     /gene_synonym="PAG608; Wig1"
                     /note="zinc finger, matrin type 3"
                     /db_xref="GeneID:64394"
                     /db_xref="RGD:620134"
     exon            1..183
                     /gene="Zmat3"
                     /gene_synonym="PAG608; Wig1"
                     /inference="alignment:Splign:2.1.0"
     exon            184..514
                     /gene="Zmat3"
                     /gene_synonym="PAG608; Wig1"
                     /inference="alignment:Splign:2.1.0"
     CDS             245..1114
                     /gene="Zmat3"
                     /gene_synonym="PAG608; Wig1"
                     /note="p53 target zinc finger protein; zinc finger protein
                     WIG-1; p53-activated gene 608 protein; wild-type
                     p53-induced gene 1"
                     /codon_start=1
                     /product="zinc finger matrin-type protein 3"
                     /protein_id="NP_071993.1"
                     /db_xref="GeneID:64394"
                     /db_xref="RGD:620134"
                     /translation="MILLQQVWLPLPNRPSTSPPMSVAARSTGTLQLPPQKAFGQEAS
                     LPLAGEEDLAKRGEPDSALEELCKPLFCKLCNVTLNSAQQAQAHYQGKNHGKKLRNYY
                     AANSCPPPARMSSVAEPVATPLVPVPPQVGSCKPGGRVILATENDYCKLCDASFSSPA
                     VAQAHYQGKNHAKRLRLAEAQSHSFSDSAEAGQRRTRKEGSEFKMVTTRRNMYTVQSN
                     SGPYFNARSRQRIPRDLAMCVTPSGQFYCSMCNVGAGEEVEFRQHLESKQHKSKVSEQ
                     RYRSEMENLGYVQ"
     exon            515..634
                     /gene="Zmat3"
                     /gene_synonym="PAG608; Wig1"
                     /inference="alignment:Splign:2.1.0"
     exon            635..801
                     /gene="Zmat3"
                     /gene_synonym="PAG608; Wig1"
                     /inference="alignment:Splign:2.1.0"
     exon            802..902
                     /gene="Zmat3"
                     /gene_synonym="PAG608; Wig1"
                     /inference="alignment:Splign:2.1.0"
     exon            903..7422
                     /gene="Zmat3"
                     /gene_synonym="PAG608; Wig1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgctgtctc ccggttccgc agtcacttcc tgcagctgtt tccctgtggc tacgctccac
       61 tgacttttga caatcaatct ccagcaacgg agcggcgatc ggcggcggtg agctcagaaa
      121 agtggtcgtg gagcgggcgg cggcgcgcgg agtggcgggg cggctgcggc ctggccggtt
      181 ccggtttgaa gactccgtcc atcccctgtc acccactgga ttatgctcgt ggctttcctg
      241 cctgatgatt cttttgcagc aggtctggct tcctttacct aaccggcctt caacctctcc
      301 tcctatgtca gtggctgcca ggtccactgg gaccttgcag ctcccgccac agaaggcttt
      361 tgggcaggaa gcatccttgc ctctggcagg ggaagaggat ttagctaaga gaggggagcc
      421 agattctgcc ctggaggagc tgtgtaagcc cctcttctgc aaactctgca atgtcacctt
      481 gaactccgct cagcaagccc aggcccacta tcagggtaaa aaccatggca agaaactccg
      541 aaattattat gcagctaaca gctgccctcc tccagccagg atgagcagcg tggcggagcc
      601 tgtagccaca cccctcgtcc ctgtccctcc ccaggtgggc tcctgcaagc cagggggcag
      661 ggtgatcctg gccacagaga atgactactg taagctgtgc gatgcctcct tcagctcccc
      721 cgcggtggca caggcgcact accaggggaa gaaccacgcc aagagacttc gtctggccga
      781 agctcagagc cactcattct cggactctgc agaggcgggg caacggcgga cccggaaaga
      841 agggagtgaa tttaagatgg tgaccaccag gaggaatatg tatacagtcc agagcaattc
      901 aggtccttac ttcaacgccc gttctcggca gaggatcccg cgagatctcg ccatgtgcgt
      961 tactccaagt ggccagtttt actgctcgat gtgtaacgtc ggagctggcg aagaggtgga
     1021 gttccggcag catctagaga gcaagcagca caaaagcaag gtgtccgagc agcggtacag
     1081 gagcgagatg gagaacctgg gctacgttca gtgatggccg ccctcacaga gaagcctgtc
     1141 ctgcctgttt gccttctgtc gacctgcctt gctttgtggt cctccatgcc tacattcctc
     1201 attcttctgc ttagtgcgag taacctgcag tggtgccatg agccgccagg tcggggtggg
     1261 cgagggaagt gtttctcata agtcacgacg atgctctttt gggccagctg tgttaaacaa
     1321 ctcacagtgg tgtgtgagct tcctgccccc tcaggtgtaa cttcttatct tggccaagtt
     1381 ctggttaagc agtagtagcc tgaccattta gagccatgaa tatttaagga tggcacccac
     1441 ttttgcagtt ttagttttac gcacattaga cgaattgact tgagttcttc tgattataga
     1501 ggagacaggt aaacggagat tcctgtttcc ggatgctcct gggaaccatt actacagtgt
     1561 ggtgttggta agatgtgctg tcatggtgtg tgcatgggtc tctcagcagc ccctggttct
     1621 ctgtggcata actctccctc cataattgac acataggttt tcttgaattc atacacgtcc
     1681 agaatactat gttcttgtgg acatgtaacg tcatctccag ctgtgaactg cacacatgta
     1741 atcctatctc ctcctgtact tagatcagct tctccgctca ccccattctc ttggcccaga
     1801 tgtgccggca gtttcggaga cccagatttg actaatgagt tgaagatgga tattctttta
     1861 gaaaatatat tttcagatga ttcaaggaaa tgcaaggatg tgtttgagat ttcaatttgg
     1921 aattctattt tcactgatga ttgtgtgaac tcctgggaca gtcattctat ggctttttga
     1981 cgattgcatc ctgacactgc cctgacatgg gcgtgcctgg aagatacccg tctgctgttt
     2041 cttaagtgga aaatttcctc tctctctctt cttttctttt cctttctttc tttctttctt
     2101 tctttctttc tttctttctt tctttctttt tttctttctt tctaagctga tcaagtttcg
     2161 gtgtcatttc caatagaaaa acatacaaac attgcatttt cttctttgcc tccttgaaga
     2221 gactgaaaaa cacagatgac tttggtgtct aatgattata atgggattct tattttttaa
     2281 ataaaaagcc atagtgtatg tctagacgga ctgatggagt gttatgtgaa cttgtgttca
     2341 ccgtgtgtcc tttgtcctcc ccttttcctt cctgtgtgtg aggccagcac gcccgtgctc
     2401 ttagggaggt atgcttctgc agaaggctta gagcaagcag tattttgcac tatttaacaa
     2461 atacatattt cactcttcgt gccacctgag agttctctgg gcagaaggag agggaggaaa
     2521 cgctcagctc cctcctttcc ttttcttctt tagaatagtt gaggacccac aatgaaaggt
     2581 taattttatg attagcttct ggaacagtac caggttactt tctcctggtg aaattgctgg
     2641 tttctggaaa agtagaactg ttcggttaag cacttgcccc ttacaaacag aagaaagtac
     2701 agcattagtg taagatttga tctccatttg tagttcctca taccaaggac ccctcctgtg
     2761 gccgtctaca gagctggtca gtttagggca atttagggtg tgtcttgtta gccgttcggt
     2821 tgctcatttt gctgctcaat ataattcttc ggtagactta aatatattgt tggccacttg
     2881 ttctgtgatg gtttaacagt ctcatctgtt ttctcacagg gtgtgtgtct aagtgtttct
     2941 gtgtttgtgt ccccagtttt atatgatatc ccagagacag tttcacctca tctttatctc
     3001 agataacctt gaaagattct gggtatggat ttacatttta taaaagttga cactcatctg
     3061 ctttgagttt tttcctctgg gaatcaagtc aaaggatatc cccttccccc atccccaaat
     3121 gctctcctcc tgtatataca gaaaacagtg gacttaagga cttgatgtgt tttcaagcct
     3181 catgaattca ggtttctagt ctcccagtgc ccttaatgga tgttagggac gcataagtgt
     3241 ggtttctttt agagtaaatg ttagatttct ggtgttattt ctatactcct ttgaactaga
     3301 gagggtgatg tgtttgtttt atgacactct ggtaccaggt tgcctatgat aactccgttt
     3361 gtttccgacc tctggaagtt tataagtaac ggctatggtc attgttgtgg atgtctcaaa
     3421 cacttagaag ttccctgact gaggctgtgt tgtccttact tgtattcagt gggtagggca
     3481 gaggctgtca gaactgcaat ggtgcagttt ctcactctgt gaactctgta tggacagcgt
     3541 cccttccttg tctggtcaag cttcggtggc atctgagtca gttaggcgag ctctctgtta
     3601 gcttagtttt gcagtaggaa tccccccccc accccccgct cccgttcccc aggaatccta
     3661 tacattttgg atgtcacagt catggatgga cagaagtgta agggggacct tggtccaaaa
     3721 ttaagtaatt gcagtttcat cgattatctg tagcatcgag gtctgttcct gtgtggctct
     3781 ctgcttcatt ctgaggccaa tcagaacacc cggatctaag gcttcaggaa gagtccggtt
     3841 tcagtcagat ggtctggatc ccatatgcct tcagagggca ttagctttgg aagttcagat
     3901 atagccctgt gtcctttgac cttgtagaca tcgcattaag caggcatttt gctggtctgg
     3961 gttgatctag tcctgctgct tgtaaatgca tgcctgttgt tttacgcctg tctgcttgcc
     4021 tcttacaaac tgaatcctgc attctcccac actgtttgtc ttgacaaaag ttcctcctca
     4081 acactttccc ttttggtttg ccactggctt caagagttag gaggtttgaa gccctggaaa
     4141 tggatgaagg gccatggctg agagcttgtg atacgctgag gtgactttcc cgcctcaccc
     4201 ctacagagct gccctgtgga gctttgtgta gcccttggtc tacagcccta caatcccagc
     4261 agggagaaaa cattatacat acatatgtat acctgattaa gtgttctgtg tagctaggga
     4321 cttggaacta tcccagcctg cgattccggg gagaatgagc agtgccagtc agtccaaggg
     4381 caggtgagtg acttcctcgt agtgctttct ttgcggagag gcccaagaat gttctgtaaa
     4441 tgtcaagaac ttgggctgga agtatttacc agaaaaactg gtgggctgtg tacccaagcg
     4501 ctggagcgtc tttagaaatg gggaaacatt ttgttggtgt atgcagaagt ttatgtagat
     4561 atttggaaca ggtgtttaaa aaaaaattct accttgcccc ctccccttaa ctctctgtta
     4621 ggcgttttat atgtgaatta aaaaaaaaaa agctttgttg cttttgtgtt gtgtttgggc
     4681 gagtgtcccg tgagctgcca tgtcagcgta gctgagtgga cactagctgt gtaaataacc
     4741 tctcatgcga catttgtgtg gatagctgtg tggcatttcc ttccattatc aatagggact
     4801 ctgtgaacgc cctttctctg tagctaccaa aaaaagccct ggcttatggt cccctgtgac
     4861 cttgtgtccg ttaaacccag aatatgagtg cctttagcaa gcgttagcat ttcacagagg
     4921 gtagagacga cagaatttac tgccattaac cactgttcat aaaatagctg gaaatagcga
     4981 cgatcctcgt gaattctgtt ctatgtcgtg tgtccccccc gtttcttagt gcagtctcgg
     5041 tttgcttttg ggtacagtgt gcactctgga caggagcctg gctgctgagg ctggcagtgg
     5101 tcacctcggc ggccatcttc gatgctacag aggactcaga gcttgagatg ctgatgctgg
     5161 aaaaacttcc tacactgacc gtgttccagc tggttcttct gtagagtgga gacaattatg
     5221 tatctacaaa cagtgtattg cgagactgtc tgggacagta gctccagatc acgctggact
     5281 tcatctctgc gtggatggag ggagcttgcc aagcaagatc gaggcctttg gaaacgacaa
     5341 cttccttcct ttgactaact gaaaacgcta aaattcctga ggtctttatg atcttttgaa
     5401 catacaatta aaccaatttt catgtagaaa tagtaacatt tgcctcagaa ttttattacg
     5461 aagaattttg gacatttgtc aaagtggaaa acattttgga gtacacctac ctaactcttc
     5521 tatctcctac tattgacatt tccccactcg tgttccttcc tatctcccat gagccaattg
     5581 ctgtgttctt ctgtctgccc ctcaggacgg atggctctat acatttcaga cagcgtccat
     5641 accatgggca gcatacacta ggattaatat ttaaatgtta atgtcttagg aagaccgcat
     5701 gtgtaggtct taacctaagc cagtaaacag tctctgttct ctcctgtgga tatcagtctt
     5761 ccttgtctct gttcttgagt gtgcttagag tttccaacaa gtctgcacca ggttccctgg
     5821 cccacaaacc ttatgttccg gacaggactt gctgtgaact cccaggcgct ataaccattc
     5881 gcctcctatg cctgtacata gcaggattaa acttggagac aacagttctg tccactgagg
     5941 ggtgggcaag ccttagagca gtctccagct ttcccccagt catgtcaggg aaaactgccg
     6001 tctgcctcca tcctgtgccc accctatgtg gccagctctg cagaactgaa ggggtttgct
     6061 caggttggat ggatcggatg ggtaggacca aatcacaggc caaccctgag tgctcttagg
     6121 ttgtaacctt aggcttccag tgtaactgaa cacttccttt gtgcccttag aaggactgta
     6181 tttattttct accaattaca attttagttt tagacatttc acagttctct tcccgtggtc
     6241 atttgttgtt ttgcgatgct ccatgtagct caggtgagtc aattctacca cgcagccaag
     6301 ggtgaccttg aactcccccg atcctcctgc ctccacctcc tggtgctggg attacaggca
     6361 tgtaccacca tgccaagcta tgaataaatt gtagttttaa ttacgtccaa agcaattgct
     6421 aaaatctcac tgcactgttg aacaccgact catgcagggt ctgcctgatt gtttcactat
     6481 tgcaaatggt gttcccatca ctgactcgcc catgcactct ctacctgatg cttttttttg
     6541 tttaagaaat gactccatat gtcagggaga gcgatattga ttgtcttagg gcaaagccct
     6601 attgggaaca aaccctcctg gaagtggctg gtcggtcgtt gttctgcctt cttctggtta
     6661 tctgatcacc caccaaaggt tctgtaagcc agtgtgtcat tttgtaagtc tcatgttgac
     6721 tctgttcacc tgtcttcccg cccccccgcc ccctcccccc gcatgggttt tgtgtgtcgt
     6781 ctttgaaatg ccttattggg tatgccaggc tctgctgtcg agcatcccag ctgtctgctg
     6841 agacatacat atcctccctg ggatgtgctc ttgatctgga agcaacactg acctagcttt
     6901 cagtatcaag ggtgcatttt aacacagcta ttgtcttaag ttagaaatga agcaggaagc
     6961 cgagagagtg tggaaccctt catgtgatca gtgtggtgac ctgtaaatgt gcttttgctg
     7021 tttcactgga agggacgcag ctaagaaacg ccagtccaaa cccgaaagtg gggctgtgtc
     7081 atatatcacg ccctccactt gtcacttggc cattgagaat ctgagcaggc catcgggcag
     7141 tgggccagtc tctatgttct ggggctacag agctgactga cgtcaccgga ttcaaaccaa
     7201 tcaactgtga attgtgaaac tgaagttgtt ctttcggttt ttatctccct cagcctatta
     7261 agtgtagaag tccgaatgtc atttaagctt agaccactta tgttggctca tcttggctgt
     7321 gtactctcat gtatgtactg atttctgata aaggcttgat gatactgtaa cggactttct
     7381 gtgttcagtt caataaaaca gtttctgagt ctcatctcaa aa
//
