LOCUS       NM_001411817            4027 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus Zic family member 3 (Zic3), mRNA.
ACCESSION   NM_001411817 XM_039099956
VERSION     NM_001411817.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4027)
  AUTHORS   Quinn ME, Haaning A and Ware SM.
  TITLE     Preaxial polydactyly caused by Gli3 haploinsufficiency is rescued
            by Zic3 loss of function in mice
  JOURNAL   Hum Mol Genet 21 (8), 1888-1896 (2012)
   PUBMED   22234993
REFERENCE   2  (bases 1 to 4027)
  AUTHORS   Sakai-Kato K, Ishiguro A, Mikoshiba K, Aruga J and Utsunomiya-Tate
            N.
  TITLE     CD spectra show the relational style between Zic-, Gli-, Glis-zinc
            finger protein and DNA
  JOURNAL   Biochim Biophys Acta 1784 (7-8), 1011-1019 (2008)
   PUBMED   18298960
REFERENCE   3  (bases 1 to 4027)
  AUTHORS   Zhu L, Zhou G, Poole S and Belmont JW.
  TITLE     Characterization of the interactions of human ZIC3 mutants with
            GLI3
  JOURNAL   Hum Mutat 29 (1), 99-105 (2008)
   PUBMED   17764085
REFERENCE   4  (bases 1 to 4027)
  AUTHORS   Ware SM, Harutyunyan KG and Belmont JW.
  TITLE     Heart defects in X-linked heterotaxy: evidence for a genetic
            interaction of Zic3 with the nodal signaling pathway
  JOURNAL   Dev Dyn 235 (6), 1631-1637 (2006)
   PUBMED   16496285
REFERENCE   5  (bases 1 to 4027)
  AUTHORS   Bogani D, Warr N, Elms P, Davies J, Tymowska-Lalanne Z, Goldsworthy
            M, Cox RD, Keays DA, Flint J, Wilson V, Nolan P and Arkell R.
  TITLE     New semidominant mutations that affect mouse development
  JOURNAL   Genesis 40 (2), 109-117 (2004)
   PUBMED   15384171
REFERENCE   6  (bases 1 to 4027)
  AUTHORS   Mizugishi K, Hatayama M, Tohmonda T, Ogawa M, Inoue T, Mikoshiba K
            and Aruga J.
  TITLE     Myogenic repressor I-mfa interferes with the function of Zic family
            proteins
  JOURNAL   Biochem Biophys Res Commun 320 (1), 233-240 (2004)
   PUBMED   15207726
REFERENCE   7  (bases 1 to 4027)
  AUTHORS   Purandare SM, Ware SM, Kwan KM, Gebbia M, Bassi MT, Deng JM, Vogel
            H, Behringer RR, Belmont JW and Casey B.
  TITLE     A complex syndrome of left-right axis, central nervous system and
            axial skeleton defects in Zic3 mutant mice
  JOURNAL   Development 129 (9), 2293-2302 (2002)
   PUBMED   11959836
REFERENCE   8  (bases 1 to 4027)
  AUTHORS   Koyabu Y, Nakata K, Mizugishi K, Aruga J and Mikoshiba K.
  TITLE     Physical and functional interactions between Zic and Gli proteins
  JOURNAL   J Biol Chem 276 (10), 6889-6892 (2001)
   PUBMED   11238441
REFERENCE   9  (bases 1 to 4027)
  AUTHORS   Mizugishi K, Aruga J, Nakata K and Mikoshiba K.
  TITLE     Molecular properties of Zic proteins as transcriptional regulators
            and their relationship to GLI proteins
  JOURNAL   J Biol Chem 276 (3), 2180-2188 (2001)
   PUBMED   11053430
REFERENCE   10 (bases 1 to 4027)
  AUTHORS   Gebbia M, Ferrero GB, Pilia G, Bassi MT, Aylsworth A, Penman-Splitt
            M, Bird LM, Bamforth JS, Burn J, Schlessinger D, Nelson DL and
            Casey B.
  TITLE     X-linked situs abnormalities result from mutations in ZIC3
  JOURNAL   Nat Genet 17 (3), 305-308 (1997)
   PUBMED   9354794
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000474.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by
            NM_001411817.2.
            
            On Sep 2, 2022 this sequence version replaced XM_039099956.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760393,
                              SAMEA5760396 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on single protein-coding
                                         transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1593              JACYVU010000474.1  189334-190926
            1594-1757           JACYVU010000474.1  192037-192200
            1758-4027           JACYVU010000474.1  193030-195299
FEATURES             Location/Qualifiers
     source          1..4027
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq36"
     gene            1..4027
                     /gene="Zic3"
                     /gene_synonym="RGD1561261"
                     /note="Zic family member 3"
                     /db_xref="GeneID:367944"
                     /db_xref="RGD:1561261"
     exon            1..1593
                     /gene="Zic3"
                     /gene_synonym="RGD1561261"
                     /inference="alignment:Splign:2.1.0"
     CDS             537..1937
                     /gene="Zic3"
                     /gene_synonym="RGD1561261"
                     /note="zinc finger protein of the cerebellum 3; Zic family
                     member 3 (odd-paired homolog, Drosophila)"
                     /codon_start=1
                     /product="zinc finger protein ZIC 3"
                     /protein_id="NP_001398746.1"
                     /db_xref="GeneID:367944"
                     /db_xref="RGD:1561261"
                     /translation="MTMLLDGGPQFPGLGVGSFGAPRHHEMPNREPAAMGLNPFGDST
                     HAAAAAAAAAAFKLSPATAHDLSSGQSSAFTPQGSGYANALGHHHHHHHHHHASQVPT
                     YGGAASAAFNSTRDFLFRQRGSGLSEAASGGGQHGLFAGSASSLHAPAGIPEPPSYLL
                     FPGLHEQGAGHPSPTGHVDNNQVHLGLRGELFGRADPYRPVASPRTDPYAASAQFPNY
                     SPMNMNMGVNVAAHHGPGAFFRYMRQPIKQELSCKWIEEAQLSRPKKSCDRTFSTMHE
                     LVTHVTMEHVGGPEQNNHVCYWEECPREGKSFKAKYKLVNHIRVHTGEKPFPCPFPGC
                     GKIFARSENLKIHKRTHTGEKPFKCEFEGCDRRFANSSDRKKHMHVHTSDKPYICKVC
                     DKSYTHPSSLRKHMKVHESQGSDSSPAASSGYESSTPPAIASANSKDTTKTPSAVQTS
                     TSHNPGLPPNFNEWYV"
     exon            1594..1757
                     /gene="Zic3"
                     /gene_synonym="RGD1561261"
                     /inference="alignment:Splign:2.1.0"
     exon            1758..4027
                     /gene="Zic3"
                     /gene_synonym="RGD1561261"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tactcttgag gtgaagaggc ttggactcgc gaggcgagca ctgaggttcg agcctactta
       61 ctgcaggctg cctgccctct ggccacgttc cgcctctgct acttggtgca gttgcgcctg
      121 aaagccggta cccaaggagc ctcctggccc cgtggttccg cgctcttgag tagaggaggg
      181 gtgtccggga caggattgac aaaccccgcc ctccacttat tattttgctt atttttcttt
      241 gtgcgatcct gttagtttgt taagcagatt tagtcctaga gtcttttctc ctcccttctc
      301 cctcctcctc tcccatctcc ctccccccaa tcctttttct tcccctcctc cctcctgtcc
      361 ctctgcagga gactctcgca gccaaggaaa gttgcagctc cgggtagcgc ctagggggtc
      421 tccgggcagt gctcaaccgc cgccatccct ttccgactac ggcccttcag ggatctcctt
      481 cgcctgcacc cttgctcact tcagccggat cttctgtgtc cagaacgccc ccacctatga
      541 cgatgctcct ggacggaggt ccgcagttcc ctgggctggg agtgggcagc tttggtgccc
      601 cgcgccacca cgagatgccc aaccgcgagc ctgcagccat gggattgaat cccttcgggg
      661 actcaaccca cgctgcggcc gccgccgctg ccgctgccgc cttcaagctg agcccagcca
      721 ccgctcacga tctgtcttcg ggccagagct cagctttcac accgcagggt tcaggttatg
      781 ccaatgccct gggccaccat caccatcacc accaccacca tcacgccagc caggtgccca
      841 cctacggcgg cgctgcctct gccgccttca actccacgcg cgactttctg ttccgtcagc
      901 gcggttctgg gctcagcgag gctgcctccg ggggcgggca gcacgggctt ttcgccggct
      961 ccgcgagcag tcttcacgct ccagctggta ttcctgagcc tcctagctac ttgctctttc
     1021 ctgggcttca tgagcagggc gcggggcacc cgtcgcccac agggcacgtg gacaacaacc
     1081 aggtccatct ggggctgcgc ggggagctat ttggccgtgc cgacccgtac cgccccgtgg
     1141 ctagtccgcg cacggacccc tacgcggcca gtgcgcagtt ccctaactac agccccatga
     1201 acatgaacat gggcgtgaac gtggcggccc accacggacc gggcgccttc tttcgttaca
     1261 tgcggcagcc catcaagcag gagctgtcct gcaagtggat cgaggaggct cagctgagcc
     1321 ggcccaagaa gagctgcgac cggaccttca gcaccatgca tgagttggtt acgcatgtca
     1381 ccatggagca tgtggggggc ccggagcaga acaaccacgt ctgctattgg gaggaatgtc
     1441 cccgcgaagg caagtccttc aaggcgaagt acaaactggt caaccacatc cgagtgcaca
     1501 ctggcgagaa gcccttccca tgtcccttcc cgggctgcgg gaagattttt gcccgctctg
     1561 agaacctcaa gatccacaag aggacccaca caggtgaaaa acctttcaaa tgtgaattcg
     1621 aaggctgtga cagacggttt gccaacagca gcgaccgcaa gaagcacatg catgtgcaca
     1681 cctcggacaa gccctatatc tgtaaagtgt gcgacaagtc ctacacacat ccgagctctc
     1741 tgcgcaaaca catgaaggtt catgaatctc aagggtcaga ttcttcccct gctgccagtt
     1801 caggttatga atcttccact ccacccgcta tagcttctgc aaacagtaaa gataccacta
     1861 aaaccccttc tgcagttcaa actagcacca gccacaaccc tggacttcct cccaatttta
     1921 acgagtggta cgtctgagga caaccaaaat gcattgaaaa gagaaaactg agacaaatca
     1981 gatggaaaat ggagttttaa agcaagaggc catatatagg gctacatctt ggtaattaca
     2041 attgttcagg aaggttttgg gcaagatcca aaagtagcca tgccctttac tcaggattag
     2101 aaaatatgtt ttggcatttg aaggaatttt ttaaaaaaat cttttcactg ctttccctgc
     2161 cccctcctct tgctctctgt acaccccgtt ctgaaactcc ttcaaatgat ttgaattaac
     2221 acttgtcctg tttcttgagg aagttattga aggcttggtg gtggtgacat taaactgatg
     2281 aaaattcttc ttcgccttag tggtgattgt ttaaactctc acagtcttaa accatgccaa
     2341 agtcctgtta tgtcttgaac ttttcttcaa agcattacac ttgtgaatgt atcttcgtct
     2401 aatggggtcg aaacttgttg ttcagtattt tttcaggctg aggatatgat gttactctac
     2461 acagattgtg acgtttagta tacagttgcc ttttgtaata acttttcttt ttgtaaatac
     2521 atatccgttg atgccatatt tatcgtttgt aatttaatta ttgctgcaag tgccgggaac
     2581 tgaacaatat ttatggataa atgttttcta acaaattctg tacagctttt gattataact
     2641 actttagcat taaacaatta ttgttttgag aaaggaacac aatttacaat ttttgaacca
     2701 tattgacttt tgttttgtaa cagcctccta caaataggag atgtgagtaa attgaatttt
     2761 gtttgttggt atttataact cactcagatc ccttttttaa ttgttaaatt atttttctat
     2821 tgcagtctag atttccttac aatgtcagtt tccatctggg gaggaccctc ctttctttat
     2881 ctctagctca gatggttgtt taactgcgag tttaaatgtg tttgtcctgg attttcggca
     2941 tgcaaatcaa ataatactga tcaattcact tagtggccat gacatctcaa tcttgtactt
     3001 caaagactga gaagctggat ttaatcattc ctgccctata tatatatata taaacataag
     3061 gtaacctaat tagttttatg tcccttagtt ctttattacc ttacaaaaaa tgaaaatggt
     3121 ggcaggatgc atgtctgttg agagatcact catataccta tatgtttgta tctatgactt
     3181 acctaatctg cctatcaaat ctctttagct tcaaaagata gcacacctct gaaatggcag
     3241 tgagcaaggc cagttgaaca gtgcttctca tggtgaaagt gcttctttaa aaaaaaaaaa
     3301 acaaaaaaca aaaaaacaaa aaaaaaagaa aaaaagaaaa acaaaaaaaa cagtctttaa
     3361 attttggatg gcaaaggctg atttgttggc tgtatatagt tcaattcatg attattacaa
     3421 ttactcataa tgtttatata gaggtgtaat aactgcagca gttcctaaaa aaaaaacatt
     3481 tgcaaactac attatttttc aagttcatta cttataggca aagatgttaa gagcattgtt
     3541 tccattaaaa tcagtaacaa tgaaaaacgg ttgtttgttt tgtgataaaa tgttaacaat
     3601 ccatttaatc tacagtgaag caactcattt ggacaaacag ttctttttac aatggttcta
     3661 tggaaaagaa aatgatcacg gttttggggg gttgaagtgg gtagagtttg gagacttttt
     3721 tagggtgctg ttggctattg agagcccaat ctctgcatga ataacagaaa agtggagata
     3781 aggaattgta aagtgtttag aaatgtaacg aataggctta agtacctctt tcgctttaag
     3841 gggcaatgct ctcagttttt ggtggcagtc aatttgatat atataatcat tttcaattct
     3901 agaattttgt tgattgttct ttctgaaaaa ataaagtctt ggcacatcgt atttatgtta
     3961 taacattttt tgtatttggt gcccaatatt ttttccatgt tcaaataaat caatctcaaa
     4021 attgaaa
//
