LOCUS       NM_001108392            2903 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus Zic family member 2 (Zic2), mRNA.
ACCESSION   NM_001108392 XM_001075422 XM_341381
VERSION     NM_001108392.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2903)
  AUTHORS   Barratt,K.S., Glanville-Jones,H.C. and Arkell,R.M.
  TITLE     The Zic2 gene directs the formation and function of node cilia to
            control cardiac situs
  JOURNAL   Genesis 52 (6), 626-635 (2014)
   PUBMED   24585447
REFERENCE   2  (bases 1 to 2903)
  AUTHORS   Ribeiro,L.A., Roessler,E., Hu,P., Pineda-Alvarez,D.E., Zhou,N.,
            Jones,M., Chandrasekharappa,S., Richieri-Costa,A. and Muenke,M.
  TITLE     Comparison of mutation findings in ZIC2 between microform and
            classical holoprosencephaly in a Brazilian cohort
  JOURNAL   Birth Defects Res A Clin Mol Teratol 94 (11), 912-917 (2012)
   PUBMED   22847929
REFERENCE   3  (bases 1 to 2903)
  AUTHORS   Hatayama,M., Ishiguro,A., Iwayama,Y., Takashima,N., Sakoori,K.,
            Toyota,T., Nozaki,Y., Odaka,Y.S., Yamada,K., Yoshikawa,T. and
            Aruga,J.
  TITLE     Zic2 hypomorphic mutant mice as a schizophrenia model and ZIC2
            mutations identified in schizophrenia patients
  JOURNAL   Sci Rep 1, 16 (2011)
   PUBMED   22355535
  REMARK    Erratum:[Sci Rep.2011;1:49]
REFERENCE   4  (bases 1 to 2903)
  AUTHORS   Garcia-Frigola,C. and Herrera,E.
  TITLE     Zic2 regulates the expression of Sert to modulate eye-specific
            refinement at the visual targets
  JOURNAL   EMBO J 29 (18), 3170-3183 (2010)
   PUBMED   20676059
REFERENCE   5  (bases 1 to 2903)
  AUTHORS   Brown,L. and Brown,S.
  TITLE     Zic2 is expressed in pluripotent cells in the blastocyst and adult
            brain expression overlaps with makers of neurogenesis
  JOURNAL   Gene Expr Patterns 9 (1), 43-49 (2009)
   PUBMED   18755297
REFERENCE   6  (bases 1 to 2903)
  AUTHORS   Koyabu,Y., Nakata,K., Mizugishi,K., Aruga,J. and Mikoshiba,K.
  TITLE     Physical and functional interactions between Zic and Gli proteins
  JOURNAL   J Biol Chem 276 (10), 6889-6892 (2001)
   PUBMED   11238441
REFERENCE   7  (bases 1 to 2903)
  AUTHORS   Mizugishi,K., Aruga,J., Nakata,K. and Mikoshiba,K.
  TITLE     Molecular properties of Zic proteins as transcriptional regulators
            and their relationship to GLI proteins
  JOURNAL   J Biol Chem 276 (3), 2180-2188 (2001)
   PUBMED   11053430
REFERENCE   8  (bases 1 to 2903)
  AUTHORS   Nolan,P.M., Peters,J., Strivens,M., Rogers,D., Hagan,J., Spurr,N.,
            Gray,I.C., Vizor,L., Brooker,D., Whitehill,E., Washbourne,R.,
            Hough,T., Greenaway,S., Hewitt,M., Liu,X., McCormack,S.,
            Pickford,K., Selley,R., Wells,C., Tymowska-Lalanne,Z., Roby,P.,
            Glenister,P., Thornton,C., Thaung,C., Stevenson,J.A., Arkell,R.,
            Mburu,P., Hardisty,R., Kiernan,A., Erven,A., Steel,K.P.,
            Voegeling,S., Guenet,J.L., Nickols,C., Sadri,R., Nasse,M.,
            Isaacs,A., Davies,K., Browne,M., Fisher,E.M., Martin,J., Rastan,S.,
            Brown,S.D. and Hunter,J.
  TITLE     A systematic, genome-wide, phenotype-driven mutagenesis programme
            for gene function studies in the mouse
  JOURNAL   Nat Genet 25 (4), 440-443 (2000)
   PUBMED   10932191
REFERENCE   9  (bases 1 to 2903)
  AUTHORS   Nagai,T., Aruga,J., Minowa,O., Sugimoto,T., Ohno,Y., Noda,T. and
            Mikoshiba,K.
  TITLE     Zic2 regulates the kinetics of neurulation
  JOURNAL   Proc Natl Acad Sci U S A 97 (4), 1618-1623 (2000)
   PUBMED   10677508
REFERENCE   10 (bases 1 to 2903)
  AUTHORS   Brown,S.A., Warburton,D., Brown,L.Y., Yu,C.Y., Roeder,E.R.,
            Stengel-Rutkowski,S., Hennekam,R.C. and Muenke,M.
  TITLE     Holoprosencephaly due to mutations in ZIC2, a homologue of
            Drosophila odd-paired
  JOURNAL   Nat Genet 20 (2), 180-183 (1998)
   PUBMED   9771712
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000015.1.
            
            On Mar 4, 2011 this sequence version replaced NM_001108392.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.58554.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1313              JAXUCZ010000015.1  105983342-105984654
            1314-1477           JAXUCZ010000015.1  105986411-105986574
            1478-2903           JAXUCZ010000015.1  105986742-105988167
FEATURES             Location/Qualifiers
     source          1..2903
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15q25"
     gene            1..2903
                     /gene="Zic2"
                     /note="Zic family member 2"
                     /db_xref="GeneID:361096"
                     /db_xref="RGD:1311174"
     exon            1..1313
                     /gene="Zic2"
                     /inference="alignment:Splign:2.1.0"
     CDS             242..1831
                     /gene="Zic2"
                     /note="zinc finger protein of the cerebellum 2; Zic family
                     member 2 (odd-paired homolog, Drosophila)"
                     /codon_start=1
                     /product="zinc finger protein ZIC 2"
                     /protein_id="NP_001101862.2"
                     /db_xref="GeneID:361096"
                     /db_xref="RGD:1311174"
                     /translation="MLLDAGPQFPAIGVGSFARHHHHSAAAAAAAAAEMQDRELSLAA
                     AQNGFVDSAAAHMGAFKLNPGAHELSPGQSSAFTSQGPGAYPGSAAAAAAAAALGPHA
                     AHVGSYSGPPFNSTRDFLFRSRGFGDSAPGGGQHGLFGPGAGGLHHAHSDAQGHLLFP
                     GLPEQHGPHASQNVLNGQMRLGLPGEVFGRSEQYRQVASPRTDPYSAAQLHNQYGPMN
                     MNMGMNMAAAAAHHHHHHHHPGAFFRYMRQQCIKQELICKWIDPEQLSNPKKSCNKTF
                     STMHELVTHVSVEHVGGPEQSNHVCFWEECPREGKPFKAKYKLVNHIRVHTGEKPFPC
                     PFPGCGKVFARSENLKIHKRTHTGEKPFQCEFEGCDRRFANSSDRKKHMHVHTSDKPY
                     LCKMCDKSYTHPSSLRKHMKVHESSPQGSESSPAASSGYESSTPPGLVSPSAEPQSSS
                     NLSPAAAAAAAAAAAAAAAVSAVHRGAGSGSSGSGGGSAAGSGGGGGGAGGGGGGSSG
                     GGSGTAGGHSGLSSNFNEWYV"
     exon            1314..1477
                     /gene="Zic2"
                     /inference="alignment:Splign:2.1.0"
     exon            1478..2903
                     /gene="Zic2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcgcctcct ccgccgccgc ctcctcttcc tctccgcgcc ttcgctcggc gcccggccgc
       61 ctgaggcaga tacaggcggc ggcggccggc gcagtagccc ggctcccgag gctgcagtcg
      121 ccagtgtttc caccgccggt tcgcggagcc cggcgtccag aggacgcgcc tcgccgatca
      181 ggaggggaaa tccaggcagc agggctcacc ggggccggcg gggcggccgg gcgcgctggc
      241 catgcttctg gacgcggggc cgcagttccc ggccatcggg gtgggcagct tcgcgcgcca
      301 ccaccaccac tcggccgcgg cagcggcggc tgcggcggcc gagatgcagg accgggagct
      361 gagcctggcg gcggcacaga acggcttcgt ggactcggcc gcagcgcaca tgggcgcctt
      421 caagctcaac cccggggcac acgaactgtc tcctggtcag agttcggcgt tcacgtcgca
      481 aggtccgggc gcctacccgg gttcggctgc agcggccgct gcagccgcgg ctctagggcc
      541 ccacgccgct cacgttggct cttattcggg gcctcccttt aattccaccc gggacttcct
      601 gttccgtagc cggggcttcg gggactcggc gccgggaggc ggccagcacg ggctcttcgg
      661 acccggcgcc ggcggcctcc accatgcgca ctcggacgcg cagggccacc ttctcttccc
      721 tggcctcccg gaacagcacg ggccgcacgc ctcgcagaac gtgctcaatg ggcaaatgcg
      781 cctagggctg ccgggcgaag tgttcgggcg ctcagagcaa taccgccaag tggccagccc
      841 gcggaccgac ccttactcgg cggcgcagct ccacaaccag tacggcccta tgaatatgaa
      901 catggggatg aacatggcag cggccgcagc ccaccaccac caccaccatc accaccctgg
      961 tgcctttttc cgctacatgc ggcagcagtg catcaagcaa gagctcatct gcaagtggat
     1021 cgacccggag cagctaagca atcccaagaa aagctgcaac aaaactttca gcaccatgca
     1081 cgagctggtg acccacgtct ctgtagagca tgtcggcggc ccggaacaga gcaaccacgt
     1141 ctgcttctgg gaggagtgtc cacgcgaggg caaacccttt aaggccaaat acaaactggt
     1201 caaccacatc cgcgtgcaca cgggcgagaa acccttccct tgtcctttcc cgggttgtgg
     1261 caaggtcttc gcacgctccg agaacctcaa gatccacaaa agaactcaca caggggagaa
     1321 acctttccag tgtgagttcg agggctgtga ccgacgcttc gccaacagca gcgacaggaa
     1381 gaagcacatg cacgtccaca cctcagataa gccctatctc tgcaagatgt gcgacaagtc
     1441 ctacacgcat cccagctcct tgcggaagca catgaaggtc catgagtcct cccctcaggg
     1501 ctccgagtcc tccccggctg ccagctctgg ctacgagtcg tccacacccc cagggttggt
     1561 gtcccccagc gcagagccac aaagcagctc caacctgtcc ccagcagcgg cagcggcggc
     1621 ggcagcggct gcagcagcgg cggccgcggt gtccgcagtg caccgaggcg cgggttctgg
     1681 cagtagcggc tccggagggg gctcggcggc cggcagcggt gggggcggcg gcggggcggg
     1741 cggcgggggc ggcggcagct ctggcggggg cagcgggaca gccggaggcc atagcggcct
     1801 ctcctccaac ttcaatgaat ggtacgtgtg aagggccagg cctttctccc attccctgtt
     1861 cccttatcca ccgtcgccct cccaaaaacc caccgagggc accttaggat catcttacta
     1921 aaattatgag tctgattttt atggtgaaaa aaattttacc agcagaagga tttttaaaag
     1981 tttttttttc tttttaaaga aaacaatcta ggcatgaaaa gcaacatctc tctgtatctc
     2041 tgaagctgaa aacataaaaa aaattttttg aagaaagtaa actccacaaa aatatcgagc
     2101 caaacttccc tagcaacccc cagcccactt tccttcccat atgcttccca gtctttttga
     2161 caaactgtac atagcggact ccttcctttt ccacggtgat tttaatggct tattggtgga
     2221 tagaagtttg tccatttgta aactccggat tgcgttccct cctgcctttc tcccattccc
     2281 cttccccaag tgacggacct tttctttttt ccttttagtt tacccagtct tttttttttt
     2341 aaagtaatgt ggaagaaaat ggtttatttt gtattgtggt attaaatatt gtgttccttt
     2401 taaatgaggc aacttgattg taaacttcat gcgactatag actggaaaat atgagccgtg
     2461 ccaaagtttc ccttctgttt cttcaacaca ccaacccata gcacacatca ccaccaccac
     2521 caacgcttgt gaatgtattt ttctgttagc tgggtttaca tgtgatgttt cagtgctttt
     2581 gcgagttcga tttgttagtt cttgtatgaa agtttggggg tggggtgggt gggagtaaac
     2641 gttgtgccgt tagctttttc cgaaataaca cccttctgta aatatccgtt gccatattta
     2701 tccatttgta attaaattat ggtattaact tgctacagag gaaacaatat ttataaagaa
     2761 tgtttcttaa ctataaatat gtacaattgt gggcataaac tgtttcagat ttttttattt
     2821 gaaggtttaa gtggtttgat catttcttgt gatgttttga gagtaatgca tacagaaata
     2881 taataaaatg tgttgaaact gca
//
