LOCUS       NM_022677               1344 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus Zic family member 1 (Zic1), mRNA.
ACCESSION   NM_022677
VERSION     NM_022677.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1344)
  AUTHORS   Lalonde R and Strazielle C.
  TITLE     Behavioral effects of neonatal lesions on the cerebellar system
  JOURNAL   Int J Dev Neurosci 43, 58-65 (2015)
   PUBMED   25907855
  REMARK    GeneRIF: This study showed that spontaneous Zic1 mutations causing
            cerebellar pathology are impaired in motor functions during the
            neonatal period.
REFERENCE   2  (bases 1 to 1344)
  AUTHORS   Sakai-Kato K, Ishiguro A, Mikoshiba K, Aruga J and Utsunomiya-Tate
            N.
  TITLE     CD spectra show the relational style between Zic-, Gli-, Glis-zinc
            finger protein and DNA
  JOURNAL   Biochim Biophys Acta 1784 (7-8), 1011-1019 (2008)
   PUBMED   18298960
REFERENCE   3  (bases 1 to 1344)
  AUTHORS   Ishiguro A, Inoue T, Mikoshiba K and Aruga J.
  TITLE     Molecular properties of Zic4 and Zic5 proteins: functional
            diversity within Zic family
  JOURNAL   Biochem Biophys Res Commun 324 (1), 302-307 (2004)
   PUBMED   15465018
REFERENCE   4  (bases 1 to 1344)
  AUTHORS   Grinberg I, Northrup H, Ardinger H, Prasad C, Dobyns WB and Millen
            KJ.
  TITLE     Heterozygous deletion of the linked genes ZIC1 and ZIC4 is involved
            in Dandy-Walker malformation
  JOURNAL   Nat Genet 36 (10), 1053-1055 (2004)
   PUBMED   15338008
REFERENCE   5  (bases 1 to 1344)
  AUTHORS   Mizugishi K, Hatayama M, Tohmonda T, Ogawa M, Inoue T, Mikoshiba K
            and Aruga J.
  TITLE     Myogenic repressor I-mfa interferes with the function of Zic family
            proteins
  JOURNAL   Biochem Biophys Res Commun 320 (1), 233-240 (2004)
   PUBMED   15207726
REFERENCE   6  (bases 1 to 1344)
  AUTHORS   Mizugishi K, Aruga J, Nakata K and Mikoshiba K.
  TITLE     Molecular properties of Zic proteins as transcriptional regulators
            and their relationship to GLI proteins
  JOURNAL   J Biol Chem 276 (3), 2180-2188 (2001)
   PUBMED   11053430
REFERENCE   7  (bases 1 to 1344)
  AUTHORS   Aruga J, Minowa O, Yaginuma H, Kuno J, Nagai T, Noda T and
            Mikoshiba K.
  TITLE     Mouse Zic1 is involved in cerebellar development
  JOURNAL   J Neurosci 18 (1), 284-293 (1998)
   PUBMED   9412507
REFERENCE   8  (bases 1 to 1344)
  AUTHORS   Nagai T, Aruga J, Takada S, Gunther T, Sporle R, Schughart K and
            Mikoshiba K.
  TITLE     The expression of the mouse Zic1, Zic2, and Zic3 gene suggests an
            essential role for Zic genes in body pattern formation
  JOURNAL   Dev Biol 182 (2), 299-313 (1997)
   PUBMED   9070329
REFERENCE   9  (bases 1 to 1344)
  AUTHORS   Yokota N, Aruga J, Takai S, Yamada K, Hamazaki M, Iwase T, Sugimura
            H and Mikoshiba K.
  TITLE     Predominant expression of human zic in cerebellar granule cell
            lineage and medulloblastoma
  JOURNAL   Cancer Res 56 (2), 377-383 (1996)
   PUBMED   8542595
REFERENCE   10 (bases 1 to 1344)
  AUTHORS   Aruga J, Yokota N, Hashimoto M, Furuichi T, Fukuda M and Mikoshiba
            K.
  TITLE     A novel zinc finger protein, zic, is involved in neurogenesis,
            especially in the cell lineage of cerebellar granule cells
  JOURNAL   J Neurochem 63 (5), 1880-1890 (1994)
   PUBMED   7931345
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF221839.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF221839.1, CB557120.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760384, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1344
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q31"
     gene            1..1344
                     /gene="Zic1"
                     /note="Zic family member 1"
                     /db_xref="GeneID:64618"
                     /db_xref="RGD:620110"
     CDS             1..1344
                     /gene="Zic1"
                     /note="zic protein member 1; zinc finger protein of the
                     cerebellum 1; Zic family member 1 (odd-paired homolog,
                     Drosophila)"
                     /codon_start=1
                     /product="zinc finger protein ZIC 1"
                     /protein_id="NP_073168.1"
                     /db_xref="GeneID:64618"
                     /db_xref="RGD:620110"
                     /translation="MLLDAGPQYPAIGVTTFGASRHHSAGDVAERDVGLGINPFADGM
                     GAFKLNPSSHELASAGQTAFTSQAPGYAAAAALGHHHHPGHVGSYSSAAFNSTRDFLF
                     RNRGFGDAAAAASAQHSLFAASAGGFGGPHGHTDAAGHLLFSGLHEQAAGHASPNVVN
                     GQMRLGFSGDMYPRPEQYGQVTSPRSEHYAAPQLHGYGPMNVNMAAHHGAGAFFRYMR
                     QPIKQELICKWIEPEQLANPKKSCNKTFSTMHELVTHVTVEHVGGPEQSNHICFWEEC
                     PREGKPFKAKYKLVNHIRVHTGEKPFPCPFPGCGKVFARSENLKIHKRTHTGEKPFKC
                     EFEGCDRRFANSSDRKKHMHVHTSDKPYLCKMCDKSYTHPSSLRKHMKVHESSSQGSQ
                     PSPAASSGYESSTPPTIVSPTTDNPTTSSMSPSSSAVHHTAGHSALSSNFNEWYV"
     exon            1..982
                     /gene="Zic1"
                     /inference="alignment:Splign:2.1.0"
     exon            983..1146
                     /gene="Zic1"
                     /inference="alignment:Splign:2.1.0"
     exon            1147..1344
                     /gene="Zic1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgctcctgg acgccggacc ccagtatcca gcgatcggtg tgaccacctt tggtgcatcc
       61 cggcaccact cggcgggcga cgtggccgaa agagacgtgg gcctgggtat caacccgttc
      121 gccgacggca tgggcgcctt caagctcaac cccagttcgc acgaactggc ctcggccggc
      181 cagacagcct tcacgtcgca ggctccgggc tacgccgctg ccgcggccct gggccaccat
      241 caccaccccg gccacgtcgg ctcctactcc agcgctgctt tcaattctac ccgggacttt
      301 ctgttccgca accggggctt cggcgacgcg gcggcggcag ctagcgccca gcacagtctc
      361 ttcgctgctt cggccggcgg tttcgggggc ccacacggcc atacggacgc cgcgggccac
      421 cttctttttt ctgggcttca cgagcaggcg gccggccacg cttcgcccaa cgtggtcaac
      481 gggcagatgc ggctaggttt ctccggggac atgtacccac ggccggaaca gtacggccag
      541 gtgaccagcc cgcgatccga gcactatgcc gcaccgcagc ttcacggcta tgggcccatg
      601 aacgtgaaca tggctgcaca ccacggcgct ggagccttct tccgctatat gcgccaaccc
      661 atcaagcaag agcttatctg taaatggatc gagccggagc agctggccaa ccccaaaaag
      721 tcctgcaaca aaactttcag caccatgcac gagctggtca cgcacgtcac ggtggagcac
      781 gtcggcggcc cagagcagag caaccacatc tgcttctggg aggagtgtcc acgcgagggc
      841 aagcccttca aagccaaata caaactggtc aaccacatcc gcgtgcatac gggcgaaaag
      901 ccttttccct gcccgtttcc tggctgcggc aaggttttcg cacgttcaga gaacctcaag
      961 atccacaaaa ggacgcacac aggggagaag cccttcaagt gcgagttcga gggctgcgac
     1021 cggcgcttcg ccaacagcag cgaccgcaag aagcacatgc acgtgcacac tagcgacaag
     1081 ccctaccttt gcaagatgtg cgataagtcc tacacgcacc ccagctctct gcgcaaacac
     1141 atgaaggtcc atgagtcctc ttctcagggc tcacagcctt cgcccgccgc cagctcgggg
     1201 tatgaatcgt ccacgccacc caccatcgtg tctcccacca cagacaaccc gaccaccagc
     1261 tccatgtcgc cctcttcctc cgcggtccac cacacagccg gccacagcgc gctctcttcc
     1321 aattttaacg aatggtacgt ttaa
//
