LOCUS       NM_001047097            9002 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus zinc fingers and homeoboxes 3 (Zhx3), mRNA.
ACCESSION   NM_001047097 XM_001057189 XM_001068695 XM_001068743 XM_230811
VERSION     NM_001047097.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 9002)
  AUTHORS   Suehiro,F., Nishimura,M., Kawamoto,T., Kanawa,M., Yoshizawa,Y.,
            Murata,H. and Kato,Y.
  TITLE     Impact of zinc fingers and homeoboxes 3 on the regulation of
            mesenchymal stem cell osteogenic differentiation
  JOURNAL   Stem Cells Dev 20 (9), 1539-1547 (2011)
   PUBMED   21174497
REFERENCE   2  (bases 1 to 9002)
  AUTHORS   Liu,G., Clement,L.C., Kanwar,Y.S., Avila-Casado,C. and Chugh,S.S.
  TITLE     ZHX proteins regulate podocyte gene expression during the
            development of nephrotic syndrome
  JOURNAL   J Biol Chem 281 (51), 39681-39692 (2006)
   PUBMED   17056598
  REMARK    GeneRIF: ZHX proteins 1, 2 and 3 are major transcriptional
            mediators of podocyte disease
            Erratum:[J Biol Chem. 2007 Apr 27;282(17):13140]
REFERENCE   3  (bases 1 to 9002)
  AUTHORS   Yamada,K., Kawata,H., Shou,Z., Hirano,S., Mizutani,T., Yazawa,T.,
            Sekiguchi,T., Yoshino,M., Kajitani,T. and Miyamoto,K.
  TITLE     Analysis of zinc-fingers and homeoboxes (ZHX)-1-interacting
            proteins: molecular cloning and characterization of a member of the
            ZHX family, ZHX3
  JOURNAL   Biochem J 373 (Pt 1), 167-178 (2003)
   PUBMED   12659632
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On May 18, 2021 this sequence version replaced NM_001047097.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.20220.1,
                                           SRR26360181.3208582.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-167               JAXUCZ010000003.1  169935364-169935530 c
            168-283             JAXUCZ010000003.1  169899256-169899371 c
            284-3265            JAXUCZ010000003.1  169853455-169856436 c
            3266-9002           JAXUCZ010000003.1  169837497-169843233 c
FEATURES             Location/Qualifiers
     source          1..9002
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q42"
     gene            1..9002
                     /gene="Zhx3"
                     /gene_synonym="Tix1"
                     /note="zinc fingers and homeoboxes 3"
                     /db_xref="GeneID:311604"
                     /db_xref="RGD:631431"
     exon            1..167
                     /gene="Zhx3"
                     /gene_synonym="Tix1"
                     /inference="alignment:Splign:2.1.0"
     exon            168..283
                     /gene="Zhx3"
                     /gene_synonym="Tix1"
                     /inference="alignment:Splign:2.1.0"
     exon            284..3265
                     /gene="Zhx3"
                     /gene_synonym="Tix1"
                     /inference="alignment:Splign:2.1.0"
     CDS             421..3276
                     /gene="Zhx3"
                     /gene_synonym="Tix1"
                     /note="zinc finger and homeodomain protein 3; triple
                     homeobox 1"
                     /codon_start=1
                     /product="zinc fingers and homeoboxes protein 3"
                     /protein_id="NP_001040562.1"
                     /db_xref="GeneID:311604"
                     /db_xref="RGD:631431"
                     /translation="MASKRKSTTPCMIPVKTMVLPGASTEAQPVEPLPEGPQQDLPSE
                     APEASSEAAPNPSSTDGSALANGHRGTLDGYVYSCKECDFRSQDVTHFVGHMTSEHTD
                     FNKDPHFVCTGCSFLAKTPEGLSLHNAKCHSGEASFLWNVTKPDNHVVVEQSVPENAS
                     SSVLAGESTEGTEIIITKTPIMKIMKGKAEAKKIHMLKENAPTQPGGEALPKPLAGET
                     EGKEGDHTFINGATPVSQASANSTKPPHTANGPLIGTVPVLPAGIAQFLSLQQPTVHP
                     QHHPHQPLPTSKALPKVMIPLSSIPTYNAAMDSNSFLKNSFHKFPYPTKAELCYLTVV
                     TKYPEEQLKIWFTAQRLKQGISWSPEEIEDARKKMFNTVIQSVPQPTITVLNTPLVAS
                     AGNVQHLIQAALPGHAVGQPEGTAGGLLVTQPLMANGLQASSSSLPLTTASVPKPTAA
                     PINTVCSNTTSAVKVVNAAQSLLTACPSITSQAFLDANIYKNKKSHEQLSALKGSFCR
                     NQFPGQSEVEHLTKVTGLSTREVRKWFSDRRYHCRNLKGTRAMVPGEHGSVLIDSVPE
                     VPFPLSSKVPEVPCVPTATSLVSHPATKRQSWHQTPDFTPTKYKERAPEQLRVLESSF
                     AQNPLPPEEELDRLRSETKMTRREIDGWFSERRKRVNAEETKKADGHAPQEEAEGAEE
                     EGRDEELASELRAPGENGSSEMFLSHTLAERKVSPIKINLKNLRVTEASGKSELPGMG
                     MGVCEPEEDGLNKAVEQPPSRVSYKKTAQQRHLLRQLFVQTQWPSNQDYDSIMAQTGL
                     PRPEVVRWFGDSRYALKNGQLKWYEDYKRGNFPPGLLVIAPGNRELLQDYYMTHKMLC
                     EEDLQTLCEKTQMSAQQVKQWFAEKMGEETRAVADTSSEDQGPGHGEPVAVDKVLGDA
                     CAALSENSEAWEPSAPEAGSEPFDTSSPQSGRQLETD"
     exon            3266..9002
                     /gene="Zhx3"
                     /gene_synonym="Tix1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaattgtgtt agctgtggaa agcagcgaac aggctggatg aaagatgagc ttcttccttt
       61 tctgtccttg tctcctgcca acccgccgct cattgtggag agggaaagag aggagatgag
      121 cagagccggt gccctgtcat ttagtgttca gacccaagat ttgcaaggcc tgaattgcaa
      181 ctagagaggc aacaagtgac tccttaaaga tgccacaggg ctgcagaagg ggaccttgaa
      241 gaggttgatg aagtgagaag aatgtttctc ccaacgacga gaagcttaat aaggaaaagt
      301 ggctttctgc gaataactga taaaactacc cttagaagcg cctcctgggc cctcatggaa
      361 tagctgggat ttgtactgca aggctttctt gcctgctgct gacccgaagt gattgtcacc
      421 atggccagca agaggaagtc cactacccca tgcatgatcc cggttaagac catggtgctg
      481 ccgggtgcca gcacagaggc tcagcctgtg gaacctctac ctgaaggtcc ccagcaggac
      541 cttccctcag aggcccctga agccagcagt gaggcagccc caaaccccag cagcactgat
      601 ggctctgccc tggcaaatgg gcaccggggc actttggacg gctacgtata ttcctgtaag
      661 gagtgtgact tcaggtccca ggatgtgacc cactttgtag gacacatgac ttcagaacac
      721 acggacttta ataaagaccc acattttgta tgtacagggt gcagtttcct ggcaaaaacc
      781 cctgaagggc tgtccctgca taatgccaag tgtcactcag gggaagccag ctttctgtgg
      841 aatgtgacca agccagacaa tcatgtggtg gtggagcaga gtgtccctga gaatgctagc
      901 tcatctgtcc tagcaggtga gtctactgaa gggactgaaa tcatcattac caagactcca
      961 atcatgaaga taatgaaagg caaagctgaa gccaagaaaa tccatatgct taaagagaac
     1021 gctcctactc agcctggcgg ggaggccttg cctaagccat tggccgggga gacagagggt
     1081 aaagaggggg accacacttt catcaatggg gccactccag tcagtcaggc atctgctaat
     1141 tccacaaaac cccctcatac tgccaatggg cccctgatag gaacagtgcc cgtattgcca
     1201 gctggcatag cacagttcct ctccctccag cagcccacag tacatcccca gcaccatccc
     1261 caccaacccc tgcccacatc caaggccctt ccaaaagtca tgatccccct gagcagcatc
     1321 ccgacataca atgcagccat ggactccaac agttttctga agaactcctt ccacaaattc
     1381 ccctacccaa ccaaagctga gctctgctac ttgactgtgg tgaccaagta tccagaagaa
     1441 cagcttaaaa tctggttcac agcccagaga ctgaagcagg gaatcagctg gtctcctgag
     1501 gagatcgaag atgccaggaa aaagatgttc aatacagtca tccagtctgt gcctcagccc
     1561 acaatcacag ttctaaacac accacttgtt gccagtgctg gcaatgtcca gcacctcatc
     1621 caggctgctc tcccaggtca tgctgtggga cagcctgagg gcacagcagg gggcctgttg
     1681 gtcactcaac cattgatggc caatgggcta caagcatcaa gctcatctct ccccctgaca
     1741 actgcatctg ttcccaagcc aactgcggca cccattaaca ctgtgtgttc aaatacaaca
     1801 tccgctgtga aggttgtcaa tgcagcccag tcactcctca cagcatgccc cagcataact
     1861 tcccaagctt tccttgatgc aaacatctac aaaaataaga agtctcatga acagctgtcg
     1921 gctctgaaag gaagcttctg ccggaaccag tttcccgggc agagtgaagt agagcacctg
     1981 accaaagtca caggcctcag caccagagag gtccggaagt ggttcagtga ccggagatat
     2041 cactgccgga acctgaaggg caccagggcc atggtgcctg gagagcatgg ctctgttctc
     2101 attgactctg tgccagaggt gccctttccc ctgtcatcta aagttccaga ggtgccctgt
     2161 gtcccaacag caacctcact agtgagtcac cctgccacca aacgacagtc ttggcaccag
     2221 accccagact tcacgccaac caaatacaaa gagagagccc cagagcagct gcgagtgcta
     2281 gagagcagct ttgcacaaaa cccacttccc cccgaggagg agctggaccg cctaagaagt
     2341 gaaacaaaaa tgacccggag ggaaattgat ggctggttct cagagaggcg gaaaagggtg
     2401 aatgcggagg agacaaagaa ggctgatggg catgcgcctc aggaggaggc agagggtgcg
     2461 gaggaggagg gtagagatga agagctggcc agtgagctga gggctcctgg tgaaaatggc
     2521 tcttcggaaa tgtttcttag ccataccttg gcagaacgga aggttagccc catcaaaatc
     2581 aacctcaaga acctgcgggt cactgaagcc agtggcaaga gtgagcttcc ggggatgggg
     2641 atgggtgtct gtgagcctga ggaagatggc ttgaacaagg cggtagagca gccgcccagc
     2701 agagtaagct acaagaagac tgcacagcag cgccacttgc tgcggcagct ctttgtccag
     2761 acacagtggc ccagcaacca ggactacgac tccatcatgg cccaaacagg gctgccccgg
     2821 ccggaggtgg ttcgctggtt tggtgatagc aggtatgccc ttaagaacgg ccagctcaag
     2881 tggtacgaag actataagag gggcaacttc ccaccaggtt tgctggtcat agcccctggc
     2941 aaccgagagc tgctgcaaga ttattacatg acacacaaga tgctgtgtga ggaggacctg
     3001 cagaccctct gcgagaagac ccagatgagt gcccagcagg tcaagcagtg gtttgctgag
     3061 aaaatgggtg aagagacccg ggctgtggca gatacaagca gtgaggatca gggccctgga
     3121 cacggagagc ctgtggcagt tgacaaggtg ctgggcgatg cctgtgcagc gctgtctgag
     3181 aacagtgaag catgggagcc aagtgctcct gaggccggct cagagccctt tgacacttca
     3241 agtccccagt ccggacgtca gctcgaaaca gactgaattt gatctgatta ctgtgaagga
     3301 ccggccagtc tgggatgctg tctgccatgt ggaaaggcca aacctgccac acatcatctt
     3361 gatggccagc tgccaggcac caggagagcc tctggagcct cgctgagccc agaacctgcc
     3421 gccaccccaa ccaccctctg cctgacactt ctaagcaagt agctatggtt tctcatcagc
     3481 ctatcctccc acagtgcggg acctttcctt ggcctcccaa ggacaaaccg ttcagattgc
     3541 atatacctag actcagaatc acgttgttag catacacagt taataaagca tcctaccaca
     3601 gacattctca atacatagga actcagctac caaagcagta caactctgac aatgccatgt
     3661 ctgttctctg ggaagctgag gccacaggga ccctcatcct ctgcgcagtg ggagtcgcag
     3721 gcatgctcag aactgcatca ggcctgaccc tacttgtctt ctcaagggaa cagactgttg
     3781 gaagagatct ctgcgtcact gagtggaggc aagccacact ttgtgccagg cttgtcttgt
     3841 gttctgattg acacagaacc caccgttacc ctaggttctg aacacagcca agctgtggca
     3901 tcaccattgg atgctaacct ctctctagtt aactgtaact ctgcttttta tggagtttga
     3961 atcatggacc aacttctcca ttatcagatc aactaaagaa accattgtaa agcccaatct
     4021 actggcctgt atgctccctt caagtcaaac tccgttagaa caaaaggaaa gcggtcaaag
     4081 tagagccagt tgctgtggtt ttggccacca cagtgctcaa tgcctcctgc aggtcagaag
     4141 gaagtacatg gtggctggta ggaagaatga ggctgaaggg cttcggagag ttgaagtgac
     4201 tagagctctc agtggtcttg agcacaaagg cctgcaggtg acagttctgg caaaatgcct
     4261 ttgtcacaca ccaagggcct ggccagctac tggtttcagg atccagaggt gctgggcatc
     4321 cctggacaga accccctgag gacattttta aagttccaca tgtatattcc cagcctgaga
     4381 aacaagtact ctatctactt tgcctaagcc tcgtgtcttt ttaattaaaa tcacaagaaa
     4441 tggtgccttt gaaacaatgg aaaacttgct tagggagctg tactaaacct taaagcccca
     4501 ggctctccta gactggcttc tctgagagca gtaggcaaag cagggcaggg gaaggaaagg
     4561 acaaacaggc tgtgtcaccc atggccccac ttaccttttg gagactccat caggaggatg
     4621 agagctttga ctaagaaggc agaggtcaac ttctaggtgt tctccctccc cctcccacgg
     4681 gaggggaata gtttaaggat gatggaggcc ttcagccttt taggaaagag ggctttcttt
     4741 gtaacccagg gtcctggaac tattatgttt ctcctgctct tcctgtcccc atagggatgg
     4801 cctcacattt gtcttagatt gaggtgttgt tttgtttttt tgactacttg gcaagttttg
     4861 cagcctattt ttgtatcctt tctgtttggg gagggaagct atttggcccc aaaccttgag
     4921 gagttggaaa gaatgaatgg tgagtgattg ttttccttca gagaacagat gcctgaaaat
     4981 tttcctttag tgtttgtgta tgtgaagatt tatataccat atatgcagga tacatactta
     5041 tttgatactt tattcataaa accatacttc ttatgtacac ttgagcttca tgtggatgtc
     5101 ctaggggaag tagtctgtgt gtgaggagag gacagtacac tggtcagctg gagctgcaga
     5161 ggaagccatc tcctaagaaa gcatctgtat gtcacttgag tggaggtgtg cctgctgggc
     5221 ctcacctcca gagcccggct gcactggcca aatggtagac tctataaaaa tgtctgaaca
     5281 atttacatgg aacagaaaca ttaagttact tgggggacat tatgcaggac acaggagcct
     5341 agtctcaggc actagtcagt cttctggatg ggaagatgca gtaacactgg ccccaccaca
     5401 tctttctcag agctggattg tccaggtaag gagtacatta gactaaatgc accttgcttc
     5461 ctttgctctt ggatgggtaa gggaaaccat ggcttggccc ttgtttgaca ggtaatggtg
     5521 agggaggcag tcacggagta ggcacttcag ggaagggctt tggataccaa gcatgagtgc
     5581 acggatagag gagttggggt gacatcacag tggccttgta cagttggaag ctcaagttgt
     5641 tctgtgtctt cagtagaagt ctggttgctg aatgaggtgg aatgcgctac tcctcgcaag
     5701 atgtgctttg tgaggggcga gccttgccca tcctctgcat tcacttggat ttaccagagg
     5761 cagtacattc taagtgttct ttgttgctgg tcttatgcta atttttttct actcacatat
     5821 gtttgtcagt tcagttataa accagaacca attctaacag aaacctaaac ttatacataa
     5881 gctttgcata ttacttgtaa ttttttgatc agagattttt cttttgggag gtgggtgtgt
     5941 tagttttggg attcctttcc ctagatgact ttgaggtcta ttagtgactg tccttgcact
     6001 tttctcttgg ctgagtgact gtggcttaca ggtgaacaaa gtaccttagc ccaagggcac
     6061 ctttccctct ttaagcacaa ggagagttgg gtgggagctg gtaggcagct acctgtatcc
     6121 tccacgctgt ccccagccag ccttgggtat gtgctaccag aaagcactct ccagacccag
     6181 atggctctca gattctactt gttctgtcag tagctatgtc acacctgtgt cccctcctcc
     6241 ctgctggccc taggacatct gtaacacagc agctaccttg tgtggaggac aggagttggg
     6301 gagcaacctt tctgattgga gactgatgtt gtcctccagg tgagtgttga gctgtccctg
     6361 tcttgagcca ttgccttttg tcttcctagt ctctacaggg accaaaatcc tcagattgga
     6421 gcagctcagt cagttccact gtcacagccc acatgtataa aggaactttc tggaaaacca
     6481 gccaagaata tcctaaaaca aaacttagaa tttgtgtttt ccctaaagcc actttgcagg
     6541 tgaacttata tcacattcat ttgcaaggct cagttttctg caggagtctt ctagatacac
     6601 aaaggtcttt ggtcaactca tcctggccaa attttggcat gctgcctggt ttttccttta
     6661 ccagccttct ctttggatcc ctgatttagc ttcctcttct cccttaagag cacactgttc
     6721 accaccatcc tccccagccc tttatgaggt gatttccatg ttttatatag caccgaagcc
     6781 tacaggcctt tctaagccca ggtcttcctg agacttcaac ctgaatttcc acactgcagt
     6841 tccttctgcc ttacagtgga gcagggaagt tacaaattcc tacatatact ccaggctcat
     6901 aaggctattg ggcggccttc agtggaatgc ctggtttagt tctgattgag taatgacaga
     6961 gctgatacag tactgcctgc tgctgacatt gctactggct tactagctag aaatctagaa
     7021 ggaattgagt cctcagagtc tatttctgcc agagtctctg ttccctggtg gccaggctgg
     7081 catctaggta gtggcaagcc caaatgtact cagagtccgg aacctgtact tagttgtgga
     7141 gtaaaagcag ttcagagggt gagtggtcct aggactgagc ctgctttgtg gggcttcctg
     7201 agtgtttgtc aacactagcc agcagtccta tgaacctgga cctccagact ggaaaaccaa
     7261 gacaggtttt tctagtctag ggcctagcag gaacatctct tcccaactcc ctaaagtctg
     7321 gagcagggat gtaaatccag agtacacgtg ggctggcttc tacagactta ggcagactgg
     7381 ttgctacaag aagaggtagg cacccgcttc cttggttctt cagtttctga aggaactgac
     7441 cagattcagt gtagtcacta ctctgtcgtc tctgtcctcc tcgagataga ccttgctgct
     7501 actctggcag gaaccaggca gaacagaggg agaatagcta tttggcagag actgtttcct
     7561 acatggtgtc ttcctgctgt ttacaagggt gggcagatgg caagtcagga cacctgagag
     7621 gggcctgcac atttacctgc ctgttttgtc aagaggctgg caggatgtgc ccatagatgg
     7681 gtgcctgcat ggtagtagct tttttttttt tttttaaatc tatgcctttt gacatgttcc
     7741 cttccatgga aagtaggtga ttcagttgaa ggtgaaatgc ctagattaag cctgctcaga
     7801 cactgactat aaaaagagct gcagtgctgt tcttctcaac aagtcccaga agagtccagg
     7861 aggcggaagt ctcttatgtg gtcccagtta acatgcagtt tgtgcttaag agagatcttg
     7921 ttcctagccc ctgtccacac agcttggtcc cgttcttgta gccccatgtg agaaggttgg
     7981 ctgcagtgag aattaacagc cattcctcag cagggttcca gcatgagtta ggtcgctctg
     8041 tgaaatcggg tgggccaatg gtcactcagg gcacgggtct ctcatggttc tgagttgctg
     8101 gctttgttca gctctgccag gaaggtcagg ctgtgtcata attgttatta aacagagaaa
     8161 acagccgacc gcttggcctc catggactat tgttctttga gttgtcctga catagccttg
     8221 gggaattggg gaggcagcca agggcctgta gtgtccttgc ttctcggttc ctggtcccca
     8281 gcacctgctc tgtgttctga tctcagtgtg gatggctttg ttttcagggg gcctgactgc
     8341 tgagaagtgt gatttgaaca gtctgccttt ggtgtgcttc ctgtctccca gaaacagctg
     8401 aagcgactgt cctggtgcta agtgagggtt acctgctact gcggccagct gtgaaggcaa
     8461 actaagaaac agcatattct gtcacataga ctttgtagag agggtatttc ctgtgtggcc
     8521 ccggctggcc tcccacctga atggtctgct tactgtgacc aagctggcct cagacttggg
     8581 tgctctccct gcctctacct cccaagcact gagttacagg catgggccac acctgctgga
     8641 gtgtaagaat cattcaccct ggcaaacatt tgaacagaaa gatggccttt gcttttggtg
     8701 tgggctgtgt gtgttgtgag aggtgcgagg atgacctctt caggctgagt atccgggcct
     8761 cctaaggtcc cccatgggga tgctgctatt tccaagatgc aaattgcaca tttcgtagat
     8821 ttttgtatct gcaaatttgg ataagggatg ggatgaggga caaaactgct tgtgtagttt
     8881 aaatgggcct caagtggtac ttccaatctt ttaactgttc ctaaataaaa acgtagacac
     8941 ttcttatctg ctgactttgt gtgtgtgggg gggggaggaa attaataaac aaaaatctaa
     9001 aa
//
