LOCUS       NM_001271056            2855 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus zinc fingers and homeoboxes 2 (Zhx2), mRNA.
ACCESSION   NM_001271056 XM_235318
VERSION     NM_001271056.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2855)
  AUTHORS   Kawamura,Y., Yamanaka,K., Poh,B., Kuribayashi,H., Koso,H. and
            Watanabe,S.
  TITLE     The role of Zhx2 transcription factor in bipolar cell
            differentiation during mouse retinal development
  JOURNAL   Biochem Biophys Res Commun 503 (4), 3023-3030 (2018)
   PUBMED   30146259
REFERENCE   2  (bases 1 to 2855)
  AUTHORS   Wu,C., Qiu,R., Wang,J., Zhang,H., Murai,K. and Lu,Q.
  TITLE     ZHX2 Interacts with Ephrin-B and regulates neural progenitor
            maintenance in the developing cerebral cortex
  JOURNAL   J Neurosci 29 (23), 7404-7412 (2009)
   PUBMED   19515908
REFERENCE   3  (bases 1 to 2855)
  AUTHORS   Clement,L.C., Liu,G., Perez-Torres,I., Kanwar,Y.S., Avila-Casado,C.
            and Chugh,S.S.
  TITLE     Early changes in gene expression that influence the course of
            primary glomerular disease
  JOURNAL   Kidney Int 72 (3), 337-347 (2007)
   PUBMED   17457373
  REMARK    GeneRIF: Upregulation of B7.1 with the downregulation of GLEPP1,
            Wilms' tumor gene (WT1), megalin, and vascular endothelial growth
            factor started early and persisted through the course of primary
            glomerular disease.
REFERENCE   4  (bases 1 to 2855)
  AUTHORS   Liu,G., Clement,L.C., Kanwar,Y.S., Avila-Casado,C. and Chugh,S.S.
  TITLE     ZHX proteins regulate podocyte gene expression during the
            development of nephrotic syndrome
  JOURNAL   J Biol Chem 281 (51), 39681-39692 (2006)
   PUBMED   17056598
  REMARK    GeneRIF: ZHX proteins 1, 2 and 3 are major transcriptional
            mediators of podocyte disease
            Erratum:[J Biol Chem. 2007 Apr 27;282(17):13140]
REFERENCE   5  (bases 1 to 2855)
  AUTHORS   Kawata,H., Yamada,K., Shou,Z., Mizutani,T., Yazawa,T., Yoshino,M.,
            Sekiguchi,T., Kajitani,T. and Miyamoto,K.
  TITLE     Zinc-fingers and homeoboxes (ZHX) 2, a novel member of the ZHX
            family, functions as a transcriptional repressor
  JOURNAL   Biochem J 373 (Pt 3), 747-757 (2003)
   PUBMED   12741956
REFERENCE   6  (bases 1 to 2855)
  AUTHORS   Peyton,D.K., Huang,M.C., Giglia,M.A., Hughes,N.K. and Spear,B.T.
  TITLE     The alpha-fetoprotein promoter is the target of Afr1-mediated
            postnatal repression
  JOURNAL   Genomics 63 (2), 173-180 (2000)
   PUBMED   10673330
REFERENCE   7  (bases 1 to 2855)
  AUTHORS   Spear,B.T.
  TITLE     Mouse alpha-fetoprotein gene 5' regulatory elements are required
            for postnatal regulation by raf and Rif
  JOURNAL   Mol Cell Biol 14 (10), 6497-6505 (1994)
   PUBMED   7523852
REFERENCE   8  (bases 1 to 2855)
  AUTHORS   Vacher,J., Camper,S.A., Krumlauf,R., Compton,R.S. and Tilghman,S.M.
  TITLE     raf regulates the postnatal repression of the mouse
            alpha-fetoprotein gene at the posttranscriptional level
  JOURNAL   Mol Cell Biol 12 (2), 856-864 (1992)
   PUBMED   1370712
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Aug 29, 2012 this sequence version replaced XM_235318.5.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ120734.1, FQ120518.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-69                JAXUCZ010000007.1  91116487-91116555
            70-143              JAXUCZ010000007.1  91187960-91188033
            144-2855            JAXUCZ010000007.1  91249012-91251723
FEATURES             Location/Qualifiers
     source          1..2855
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q33"
     gene            1..2855
                     /gene="Zhx2"
                     /note="zinc fingers and homeoboxes 2"
                     /db_xref="GeneID:314988"
                     /db_xref="RGD:727926"
     exon            1..69
                     /gene="Zhx2"
                     /inference="alignment:Splign:2.1.0"
     exon            70..143
                     /gene="Zhx2"
                     /inference="alignment:Splign:2.1.0"
     exon            144..2855
                     /gene="Zhx2"
                     /inference="alignment:Splign:2.1.0"
     CDS             345..2855
                     /gene="Zhx2"
                     /note="AFP regulator 1; regulator of AFP;
                     alpha-fetoprotein regulator 1; zinc finger and homeodomain
                     protein 2; transcription factor ZHX2"
                     /codon_start=1
                     /product="zinc fingers and homeoboxes protein 2"
                     /protein_id="NP_001257985.1"
                     /db_xref="GeneID:314988"
                     /db_xref="RGD:727926"
                     /translation="MASKRKSTTPCMVRTSQVVEQDVLEEADRAKDKGLGVPPSDVSK
                     ERWAAEPEPSSKESEVVEVRSVGESQSKKLQGGYECKYCPYSTQNLNEFTEHVDMQHP
                     NVILNPLYVCAECNFTTKKYDSLSDHNSKFHPGETNFKLKLIKRNNQTVLEQSIEATN
                     HVVSITASAPGSSDNDPGVSVGKTATVKTGKQKADAKKVPKKPDEAAPDNHMEGTARL
                     VTDTAEILSRLGSVELLHDSLGHVMPSVQLPPNINLVPKVPVPLNTTKYNSALDTNAT
                     MINSFNKFPYPTQAELSWLTAASKHPEEHIRIWFATQRLKHGISWSPEEVEEARKKMF
                     NGTIQSVPPTITVLPAQLTPTKVSQPILQTALPCQILGQPSLVLTQVTSGSTAVSCSP
                     ITLAVAGVTNHGQKRPLVTPQAAPEPKRPHIAQVPEPPPKVANTPLTPASDRKKTKLQ
                     IAHLKASFLQSQFPDDAEVYRLIEVTGLARSEIKKWFSDHRYRCQRGIVHITSESLAK
                     DQMAITGTRHGRTYHVYPDFAAQKFKEKSQGQLKTLEDSFLKSSFPTQAEVERLRVET
                     KLSRREIDSWFSERRKLRDSMEQAVLDSMGSGKKGSDVVAPNGALSRLDQLSGAQLAG
                     PLPSPSSAVVQNQEQVHLLRSTFARTQWPTPQEYDQLAAKTGLVRTEIVRWFKENRCL
                     LKTGTLSWLEQYQRHHLSDDHGHDVASRRATKHVAESPKNGSEVAHQYAKDPKALGEE
                     ESEKLVPRVKLVGDPSKDCLAGKPSEATSDRSEGSRDGQGSEENEESGIVDFVEVTVG
                     EEDAISEKWGSWSQRVAEGTVERADSDSDSTPAEAGQA"
ORIGIN      
        1 attttggaac gcccgtgcct cgtctccgcg ttcccagccc gggtccccgc gttcgcagcc
       61 ccggcgcagg tctccatgta ctggctgctc tgggaatccg gctgcaagag tccaaggatg
      121 taaggaactc ccagcagaca ctgatatgaa gcctcctggt ttgctcggag attgctacgg
      181 ttacaatttt ctgtgctgaa atccttctga aacactcagg cggaaggctt cagcatccaa
      241 gggaagccaa aggcatttga gaggaagtaa agcccagagc caagaatctc gctgtccttc
      301 gtctacccac tccaaaaaga aggcattgct cccaggcagg cagcatggca agcaaacgga
      361 aatcgacaac gccgtgcatg gtccggacat cacaggtggt agaacaagac gtgctggagg
      421 aggcagacag ggccaaagac aaaggactgg gcgtgccacc gtccgatgtg agcaaggaga
      481 ggtgggcagc agagccggaa ccctcgtcca aagaaagcga ggtggtggag gtgagatcgg
      541 tgggggagag ccagtccaag aaactccagg gtgggtatga gtgcaagtac tgcccttact
      601 ccacgcaaaa cctgaatgag ttcacggagc acgtggatat gcagcacccc aacgtgattc
      661 tcaaccccct ctacgtatgt gccgaatgta acttcacaac caaaaagtat gactccctgt
      721 ctgaccacaa ctccaagttc catcccgggg agaccaactt caagctgaag ttaatcaagc
      781 gtaataatca gacggtccta gagcagtcca tcgaggccac caaccacgtt gtgtccatca
      841 ctgccagtgc tcctggaagt agtgataatg accccggggt ctcagtaggt aagactgcca
      901 cggtgaagac aggaaagcag aaggcagatg ccaagaaagt gcccaagaag cctgatgagg
      961 ctgccccaga caaccatatg gaagggactg cccgcctggt gacagacaca gccgagatcc
     1021 tgtccagact tggaagtgtg gagctccttc acgattcact gggacacgtc atgccttccg
     1081 tacagctgcc accaaatatc aaccttgtcc ccaaggtccc cgtcccgctg aatactacca
     1141 aatacaactc tgccctggac acaaatgcta ccatgatcaa ctccttcaac aagttccctt
     1201 accccaccca ggctgagctc tcctggctga ccgcagcctc caaacaccca gaggagcata
     1261 tccgaatctg gtttgccacc cagcgtttaa agcatggtat cagctggtcc ccagaggagg
     1321 tggaggaggc ccgaaagaag atgtttaacg gcacgattca gtcagtaccc ccaactatca
     1381 ctgtgcttcc tgcacagctg acccccacaa aagtgtcaca gcccatcctc cagacagccc
     1441 taccgtgcca gatccttggc cagcccagcc tggtgctgac tcaagtgaca agtgggtcaa
     1501 cagctgtctc gtgttctccc atcacacttg ccgtggctgg agtgaccaac catggccaga
     1561 agagacctct ggtgactcct caagctgccc ctgagccgaa gcgtccacac atcgcccagg
     1621 tgccagaacc tccacccaag gtggccaata ccccactcac gccagctagt gatcgcaaga
     1681 agaccaagtt acagatcgcc cacctcaagg caagcttctt acagagccag ttccctgacg
     1741 atgccgaggt gtaccggctc attgaggtga caggccttgc caggagtgag atcaagaagt
     1801 ggttcagcga ccatcgctac cggtgtcaga gaggcattgt ccacatcacc agcgaatccc
     1861 ttgccaaaga ccagatggcc attactggca cccgacacgg tcgcacctac cacgtatacc
     1921 cagactttgc cgcccagaag ttcaaagaga aaagccaggg acagttgaaa accctggaag
     1981 acagctttct gaaaagctct tttcccaccc aggcagaagt agaacggctg agggtggaaa
     2041 ccaagctaag caggagggaa atcgactcct ggttttccga gaggcgaaag cttcgagaca
     2101 gcatggagca ggctgtcttg gattccatgg ggtctggcaa aaagggctcg gatgtggtag
     2161 cccccaatgg tgctctatcc cgacttgatc agctctctgg tgcccagtta gctggtcctt
     2221 tgcccagtcc ttcatcagca gttgtacaaa atcaagagca ggttcaccta ctcaggagca
     2281 cctttgcaag aacccagtgg cccactcctc aggagtacga ccagttagct gccaagactg
     2341 gcctggtccg aactgagatt gtgcgctggt tcaaggagaa cagatgctta ctaaaaactg
     2401 gaacgttgag ctggttggag cagtatcaga ggcatcacct gtcagatgac catggccacg
     2461 atgtcgcatc aagaagagcg acaaaacacg ttgctgagag cccaaagaat ggaagcgagg
     2521 tggctcacca gtatgccaag gaccccaaag ccctcggcga ggaggaatcc gagaagctgg
     2581 tccccagggt gaaattggtc ggcgatccat ccaaggactg tctggcgggc aagccctcag
     2641 aggccacctc agacagatcc gagggtagcc gagatggcca gggcagcgag gaaaacgagg
     2701 agtcaggcat cgtggacttt gtggaggtga cggttggaga ggaggacgcc atctcagaga
     2761 agtggggtag ctggagtcag agagtagcag aaggcacagt agaaagagcg gactccgact
     2821 cggacagcac ccctgcagag gccggccaag cctga
//
