LOCUS       NP_001257985             836 aa            linear   ROD 28-MAR-2024
DEFINITION  zinc fingers and homeoboxes protein 2 [Rattus norvegicus].
ACCESSION   NP_001257985 XP_235318
VERSION     NP_001257985.1
DBSOURCE    REFSEQ: accession NM_001271056.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 836)
  AUTHORS   Kawamura,Y., Yamanaka,K., Poh,B., Kuribayashi,H., Koso,H. and
            Watanabe,S.
  TITLE     The role of Zhx2 transcription factor in bipolar cell
            differentiation during mouse retinal development
  JOURNAL   Biochem Biophys Res Commun 503 (4), 3023-3030 (2018)
   PUBMED   30146259
REFERENCE   2  (residues 1 to 836)
  AUTHORS   Wu,C., Qiu,R., Wang,J., Zhang,H., Murai,K. and Lu,Q.
  TITLE     ZHX2 Interacts with Ephrin-B and regulates neural progenitor
            maintenance in the developing cerebral cortex
  JOURNAL   J Neurosci 29 (23), 7404-7412 (2009)
   PUBMED   19515908
REFERENCE   3  (residues 1 to 836)
  AUTHORS   Clement,L.C., Liu,G., Perez-Torres,I., Kanwar,Y.S., Avila-Casado,C.
            and Chugh,S.S.
  TITLE     Early changes in gene expression that influence the course of
            primary glomerular disease
  JOURNAL   Kidney Int 72 (3), 337-347 (2007)
   PUBMED   17457373
  REMARK    GeneRIF: Upregulation of B7.1 with the downregulation of GLEPP1,
            Wilms' tumor gene (WT1), megalin, and vascular endothelial growth
            factor started early and persisted through the course of primary
            glomerular disease.
REFERENCE   4  (residues 1 to 836)
  AUTHORS   Liu,G., Clement,L.C., Kanwar,Y.S., Avila-Casado,C. and Chugh,S.S.
  TITLE     ZHX proteins regulate podocyte gene expression during the
            development of nephrotic syndrome
  JOURNAL   J Biol Chem 281 (51), 39681-39692 (2006)
   PUBMED   17056598
  REMARK    GeneRIF: ZHX proteins 1, 2 and 3 are major transcriptional
            mediators of podocyte disease
            Erratum:[J Biol Chem. 2007 Apr 27;282(17):13140]
REFERENCE   5  (residues 1 to 836)
  AUTHORS   Kawata,H., Yamada,K., Shou,Z., Mizutani,T., Yazawa,T., Yoshino,M.,
            Sekiguchi,T., Kajitani,T. and Miyamoto,K.
  TITLE     Zinc-fingers and homeoboxes (ZHX) 2, a novel member of the ZHX
            family, functions as a transcriptional repressor
  JOURNAL   Biochem J 373 (Pt 3), 747-757 (2003)
   PUBMED   12741956
REFERENCE   6  (residues 1 to 836)
  AUTHORS   Peyton,D.K., Huang,M.C., Giglia,M.A., Hughes,N.K. and Spear,B.T.
  TITLE     The alpha-fetoprotein promoter is the target of Afr1-mediated
            postnatal repression
  JOURNAL   Genomics 63 (2), 173-180 (2000)
   PUBMED   10673330
REFERENCE   7  (residues 1 to 836)
  AUTHORS   Spear,B.T.
  TITLE     Mouse alpha-fetoprotein gene 5' regulatory elements are required
            for postnatal regulation by raf and Rif
  JOURNAL   Mol Cell Biol 14 (10), 6497-6505 (1994)
   PUBMED   7523852
REFERENCE   8  (residues 1 to 836)
  AUTHORS   Vacher,J., Camper,S.A., Krumlauf,R., Compton,R.S. and Tilghman,S.M.
  TITLE     raf regulates the postnatal repression of the mouse
            alpha-fetoprotein gene at the posttranscriptional level
  JOURNAL   Mol Cell Biol 12 (2), 856-864 (1992)
   PUBMED   1370712
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Aug 29, 2012 this sequence version replaced XP_235318.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ120734.1, FQ120518.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..836
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q33"
     Protein         1..836
                     /product="zinc fingers and homeoboxes protein 2"
                     /note="AFP regulator 1; regulator of AFP;
                     alpha-fetoprotein regulator 1; zinc finger and homeodomain
                     protein 2; transcription factor ZHX2"
                     /calculated_mol_wt=91977
     Region          24..58
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80VX4.2)"
     Region          27..77
                     /region_name="Interaction with EFNB1.
                     /evidence=ECO:0000250|UniProtKB:Q8C0C0"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80VX4.2)"
     Region          106..158
                     /region_name="zf_C2H2_ZHX"
                     /note="Zinc-fingers and homeoboxes C2H2 finger domain;
                     pfam18387"
                     /db_xref="CDD:465737"
     Region          168..210
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80VX4.2)"
     Region          195..358
                     /region_name="Required for homodimerization.
                     /evidence=ECO:0000250|UniProtKB:Q9Y6X8"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80VX4.2)"
     Region          263..497
                     /region_name="Required for interaction with NFYA.
                     /evidence=ECO:0000250|UniProtKB:Q9Y6X8"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80VX4.2)"
     Region          263..446
                     /region_name="Required for repressor activity.
                     /evidence=ECO:0000250|UniProtKB:Q9Y6X8"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80VX4.2)"
     Region          272..321
                     /region_name="homeodomain"
                     /note="Homeodomain; DNA binding domains involved in the
                     transcriptional regulation of key eukaryotic developmental
                     processes; may bind to DNA as monomers or as homo- and/or
                     heterodimers, in a sequence-specific manner; cd00086"
                     /db_xref="CDD:238039"
     Region          317..446
                     /region_name="Required for nuclear localization.
                     /evidence=ECO:0000250|UniProtKB:Q9Y6X8"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80VX4.2)"
     Region          404..442
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80VX4.2)"
     Region          444..496
                     /region_name="homeodomain"
                     /note="Homeodomain; DNA binding domains involved in the
                     transcriptional regulation of key eukaryotic developmental
                     processes; may bind to DNA as monomers or as homo- and/or
                     heterodimers, in a sequence-specific manner; cd00086"
                     /db_xref="CDD:238039"
     Site            order(445,485,488..489,492)
                     /site_type="other"
                     /note="specific DNA base contacts [nucleotide binding]"
                     /db_xref="CDD:238039"
     Region          537..582
                     /region_name="HOX"
                     /note="Homeodomain; smart00389"
                     /db_xref="CDD:197696"
     Region          636..684
                     /region_name="homeodomain"
                     /note="Homeodomain; DNA binding domains involved in the
                     transcriptional regulation of key eukaryotic developmental
                     processes; may bind to DNA as monomers or as homo- and/or
                     heterodimers, in a sequence-specific manner; cd00086"
                     /db_xref="CDD:238039"
     Region          700..836
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80VX4.2)"
     Site            824
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8C0C0; propagated from
                     UniProtKB/Swiss-Prot (Q80VX4.2)"
     Site            826
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8C0C0; propagated from
                     UniProtKB/Swiss-Prot (Q80VX4.2)"
     CDS             1..836
                     /gene="Zhx2"
                     /coded_by="NM_001271056.1:345..2855"
                     /db_xref="GeneID:314988"
                     /db_xref="RGD:727926"
ORIGIN      
        1 maskrksttp cmvrtsqvve qdvleeadra kdkglgvpps dvskerwaae pepsskesev
       61 vevrsvgesq skklqggyec kycpystqnl neftehvdmq hpnvilnply vcaecnfttk
      121 kydslsdhns kfhpgetnfk lklikrnnqt vleqsieatn hvvsitasap gssdndpgvs
      181 vgktatvktg kqkadakkvp kkpdeaapdn hmegtarlvt dtaeilsrlg svellhdslg
      241 hvmpsvqlpp ninlvpkvpv plnttkynsa ldtnatmins fnkfpyptqa elswltaask
      301 hpeehiriwf atqrlkhgis wspeeveear kkmfngtiqs vpptitvlpa qltptkvsqp
      361 ilqtalpcqi lgqpslvltq vtsgstavsc spitlavagv tnhgqkrplv tpqaapepkr
      421 phiaqvpepp pkvantpltp asdrkktklq iahlkasflq sqfpddaevy rlievtglar
      481 seikkwfsdh ryrcqrgivh itseslakdq maitgtrhgr tyhvypdfaa qkfkeksqgq
      541 lktledsflk ssfptqaeve rlrvetklsr reidswfser rklrdsmeqa vldsmgsgkk
      601 gsdvvapnga lsrldqlsga qlagplpsps savvqnqeqv hllrstfart qwptpqeydq
      661 laaktglvrt eivrwfkenr cllktgtlsw leqyqrhhls ddhghdvasr ratkhvaesp
      721 kngsevahqy akdpkalgee eseklvprvk lvgdpskdcl agkpseatsd rsegsrdgqg
      781 seeneesgiv dfvevtvgee daisekwgsw sqrvaegtve radsdsdstp aeagqa
//
