LOCUS       NM_133620               4530 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus zinc fingers and homeoboxes 1 (Zhx1), mRNA.
ACCESSION   NM_133620
VERSION     NM_133620.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4530)
  AUTHORS   Clement,L.C., Liu,G., Perez-Torres,I., Kanwar,Y.S., Avila-Casado,C.
            and Chugh,S.S.
  TITLE     Early changes in gene expression that influence the course of
            primary glomerular disease
  JOURNAL   Kidney Int 72 (3), 337-347 (2007)
   PUBMED   17457373
  REMARK    GeneRIF: Upregulation of B7.1 with the downregulation of GLEPP1,
            Wilms' tumor gene (WT1), megalin, and vascular endothelial growth
            factor started early and persisted through the course of primary
            glomerular disease.
REFERENCE   2  (bases 1 to 4530)
  AUTHORS   Kim,S.H., Park,J., Choi,M.C., Kim,H.P., Park,J.H., Jung,Y.,
            Lee,J.H., Oh,D.Y., Im,S.A., Bang,Y.J. and Kim,T.Y.
  TITLE     Zinc-fingers and homeoboxes 1 (ZHX1) binds DNA methyltransferase
            (DNMT) 3B to enhance DNMT3B-mediated transcriptional repression
  JOURNAL   Biochem Biophys Res Commun 355 (2), 318-323 (2007)
   PUBMED   17303076
REFERENCE   3  (bases 1 to 4530)
  AUTHORS   Liu,G., Clement,L.C., Kanwar,Y.S., Avila-Casado,C. and Chugh,S.S.
  TITLE     ZHX proteins regulate podocyte gene expression during the
            development of nephrotic syndrome
  JOURNAL   J Biol Chem 281 (51), 39681-39692 (2006)
   PUBMED   17056598
  REMARK    GeneRIF: ZHX proteins 1, 2 and 3 are major transcriptional
            mediators of podocyte disease
            Erratum:[J Biol Chem. 2007 Apr 27;282(17):13140]
REFERENCE   4  (bases 1 to 4530)
  AUTHORS   Kawata,H., Yamada,K., Shou,Z., Mizutani,T., Yazawa,T., Yoshino,M.,
            Sekiguchi,T., Kajitani,T. and Miyamoto,K.
  TITLE     Zinc-fingers and homeoboxes (ZHX) 2, a novel member of the ZHX
            family, functions as a transcriptional repressor
  JOURNAL   Biochem J 373 (Pt 3), 747-757 (2003)
   PUBMED   12741956
REFERENCE   5  (bases 1 to 4530)
  AUTHORS   Yamada,K., Kawata,H., Shou,Z., Hirano,S., Mizutani,T., Yazawa,T.,
            Sekiguchi,T., Yoshino,M., Kajitani,T. and Miyamoto,K.
  TITLE     Analysis of zinc-fingers and homeoboxes (ZHX)-1-interacting
            proteins: molecular cloning and characterization of a member of the
            ZHX family, ZHX3
  JOURNAL   Biochem J 373 (Pt 1), 167-178 (2003)
   PUBMED   12659632
REFERENCE   6  (bases 1 to 4530)
  AUTHORS   Yamada,K., Kawata,H., Matsuura,K., Shou,Z., Hirano,S., Mizutani,T.,
            Yazawa,T., Yoshino,M., Sekiguchi,T., Kajitani,T. and Miyamoto,K.
  TITLE     Functional analysis and the molecular dissection of zinc-fingers
            and homeoboxes 1 (ZHX1)
  JOURNAL   Biochem Biophys Res Commun 297 (2), 368-374 (2002)
   PUBMED   12237128
REFERENCE   7  (bases 1 to 4530)
  AUTHORS   Hirano,S., Yamada,K., Kawata,H., Shou,Z., Mizutani,T., Yazawa,T.,
            Kajitani,T., Sekiguchi,T., Yoshino,M., Shigematsu,Y., Mayumi,M. and
            Miyamoto,K.
  TITLE     Rat zinc-fingers and homeoboxes 1 (ZHX1), a nuclear
            factor-YA-interacting nuclear protein, forms a homodimer
  JOURNAL   Gene 290 (1-2), 107-114 (2002)
   PUBMED   12062805
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Nov 26, 2020 this sequence version replaced NM_133620.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB072439.1, SRR26643298.40119.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760434,
                                           SAMN12840105 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-54                JAXUCZ010000007.1  91500415-91500468   c
            55-165              JAXUCZ010000007.1  91493661-91493771   c
            166-3017            JAXUCZ010000007.1  91477167-91480018   c
            3018-4530           JAXUCZ010000007.1  91472193-91473705   c
FEATURES             Location/Qualifiers
     source          1..4530
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q33"
     gene            1..4530
                     /gene="Zhx1"
                     /note="zinc fingers and homeoboxes 1"
                     /db_xref="GeneID:171159"
                     /db_xref="RGD:620010"
     exon            1..54
                     /gene="Zhx1"
                     /inference="alignment:Splign:2.1.0"
     exon            55..165
                     /gene="Zhx1"
                     /inference="alignment:Splign:2.1.0"
     exon            166..3017
                     /gene="Zhx1"
                     /inference="alignment:Splign:2.1.0"
     CDS             393..3014
                     /gene="Zhx1"
                     /note="zinc finger and homeodomain protein 1"
                     /codon_start=1
                     /product="zinc fingers and homeoboxes protein 1"
                     /protein_id="NP_598304.2"
                     /db_xref="GeneID:171159"
                     /db_xref="RGD:620010"
                     /translation="MASRRKSTTPCMVLASEQDPDLELISDLEEGPPVLTPVENARAE
                     SVSSDEEVHESVDSDNQQNKKVEGGYECKYCTFQTPDLNMFTFHVDSEHPNVVLNSSY
                     VCVECNFLTKRYDALSEHNLKYHPGEENFKLTMVKRNNQTIFEQTINDLTFDGSFVKE
                     ENTEQGESIDVSSSGISISKTPIMKMMKNKVENKRITVHHNSAEGTSEEKENGVKASR
                     EENAENTSSSASESNTSTSTVNRVHPSPAGTVVTPTAVLPGLAQVITAVSAQQNSNLV
                     PKVLIPVNSIPTYNAALDNNPLLLNTYNKFPYPTMSEITVLSAQAKYTEEQIKIWFSA
                     QRLKHGVSWTPEEVEEARRKQFNGTVHTVPQTITVIPTHISTGSNGLPSILQTCQIVG
                     QPGLVLTQVAGANTLPVTAPIALTVAGVPNQTNVQKSQVPAAQPAAETKPATAAVPSS
                     PSVRPEAALVNPDSFGIRAKKTKEQLAELKVSYLKNQFPHDSEIIRLMKITGLTKGEI
                     KKWFSDTRYNQRNSKSNQCLHLNNDSSATIIIDSSDETPEPPAAAASQPKQSWNPFPD
                     FAPQKFKEKTAEQLRVLQASFLNSSVLTDEELNRLRAQTKLTRREIDAWFTEKNKTKA
                     LKDEKVEVDESNVGSSKEEPGENSPGDEAVAPKSAGTGKICKKTPEQLHMLKSAFVRT
                     QWPSPEEYDKLAEESGLARTDIVSWFGDTRYAWKNGNLKWYYYYQSSNSSSLNGLSSL
                     RKRGRGRPKGRGRGRPRGRPRGGKRMNTWDRVPSLIKFKTGTAILKDYYLKHKFLNEQ
                     DLDELVNRSHMGYEQVREWFAERQRRSELGIELFEENEEEDEVIDDQEEDEEETDDSD
                     TWEPPRHVKRKLSKSDD"
     exon            3018..4530
                     /gene="Zhx1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctctgaaatg caagatggcg gcggcgaggc gctgaggcga ggcggcccct gcagaagact
       61 gctagctact ttgggacaat ttgcaatgat ggcctgagcc aagtacctca tttgaaggga
      121 taaccttccg ctttaaggaa cataatgctg aagaagctat ggcaggtgat tggagttgtg
      181 cttcatacat ttcagcagtt cagcagtgtt ttatctgcca actaagcttt ttacttgagt
      241 gcaccatgga gacgctacta atgagacttg ttgagcacaa aagtggactt gaagagccag
      301 aagccactgt tttccaatga aggattccaa acagttttaa gcctcagtgc ttttaaatca
      361 ccagagattc cctccctgcc cctaaaatca aaatggcaag cagacgaaaa tcaacaacac
      421 cttgcatggt ccttgccagt gagcaggatc cagatcttga gttgatatcg gatttggaag
      481 aaggccctcc cgtccttaca cccgtagaaa atgctagagc agagagtgtc tccagcgatg
      541 aagaagttca cgaatctgtg gattctgaca atcagcaaaa taagaaagtg gaagggggct
      601 atgaatgtaa atactgtact tttcaaactc cagatctaaa tatgtttact ttccatgtag
      661 attcagaaca tcccaatgtt gtgctgaatt catcctatgt ttgtgttgaa tgcaattttc
      721 ttaccaaaag gtatgatgca ctttctgagc ataatctgaa ataccaccca ggagaagaaa
      781 atttcaaact gactatggtg aagcggaata accagacaat ctttgaacag acaataaatg
      841 atctgacttt tgatggcagt tttgttaaag aggagaatac agaacaagga gaatccatag
      901 atgtttcttc ttcgggaatc tccattagta aaactcccat tatgaaaatg atgaaaaata
      961 aggtagaaaa caaacggatt acagttcacc ataactcagc tgagggcact tctgaagaga
     1021 aagagaatgg agtaaaagca agccgggaag aaaatgcaga aaatacgagt tcttcagctt
     1081 cagaatctaa cacaagtact tccactgtca accgagtgca tcccagtcct gcaggcacag
     1141 tggtgacccc cacagctgtt cttcctgggc tagcacaggt gataactgca gtctccgctc
     1201 aacagaactc aaacttggtc cctaaggtct taatccctgt taatagcatt ccaacctaca
     1261 atgctgcatt ggataacaat cctcttctac ttaacaccta caacaaattc ccttatccta
     1321 caatgtcaga aattacagtt ctttctgctc aagcaaaata tacagaggaa cagatcaaga
     1381 tctggttttc agcccaacgt ttaaagcatg gggttagttg gactcctgaa gaagtagagg
     1441 aggcaagaag aaaacaattc aatggaacag tgcatactgt acctcagacc ataactgtta
     1501 ttcctacaca catttccaca ggaagtaatg ggttaccatc tattttacaa acatgccaaa
     1561 tagttggtca gccaggtctg gtccttactc aagtagctgg agcaaacacc ttgccagtaa
     1621 cggctcccat tgctctgaca gtggcagggg ttccaaatca aacaaatgta caaaagagtc
     1681 aagtgcctgc tgctcagcct gctgcagaaa caaagccagc cacagcagca gttccatcat
     1741 cgccaagtgt caggcctgaa gctgcactag tgaacccaga ttcatttggt attcgggcca
     1801 aaaagactaa ggaacagctg gcagaactga aagttagcta ccttaaaaac cagtttcccc
     1861 acgactcaga gatcatcagg cttatgaaaa taacaggcct taccaaaggc gagattaaaa
     1921 aatggtttag tgatacaagg tacaaccaga gaaattcaaa gagtaaccag tgcttacatc
     1981 tcaataacga ctcctctgcc actatcatca tagactccag tgatgaaacc ccagaacccc
     2041 cagctgcagc tgcgtcacag ccgaaacagt cctggaatcc ctttcctgac tttgctcccc
     2101 agaagtttaa agagaaaact gcagagcaac ttcgtgtcct tcaggcaagt tttctcaaca
     2161 gttctgtact tacagatgaa gaattaaata ggttaagagc gcaaaccaaa cttactagaa
     2221 gagaaattga tgcttggttt acagagaaaa ataaaacaaa agctttaaag gatgagaaag
     2281 tagaagtaga tgaaagtaat gtaggtagtt ccaaagaaga acctggagaa aattctcctg
     2341 gagacgaagc cgttgcacct aagtcagcag ggacaggcaa gatatgtaag aagacaccag
     2401 agcaactgca catgcttaaa agtgcatttg tccgaacaca gtggccgtca ccagaagagt
     2461 atgacaagct ggctgaagaa agtgggcttg ccagaacaga catagttagt tggtttggag
     2521 atacccgtta tgcttggaag aatgggaact tgaaatggta ctactactat caaagctcca
     2581 attcaagtag tttgaatggt ctgtcctccc ttaggaaaag agggagaggc agacccaaag
     2641 gacgaggcag aggcagacca cgtgggcggc ccagaggagg aaaaagaatg aacacctggg
     2701 acagggtacc gtcgctcata aagtttaaaa ctggaacagc aatacttaaa gattattacc
     2761 tgaagcacaa atttcttaat gagcaagacc ttgatgaact tgtcaacaga tcacacatgg
     2821 gttacgagca ggtcagagag tggtttgcag aaagacaaag aagatctgag ttaggtatag
     2881 aattatttga ggaaaatgag gaggaagatg aggttattga tgatcaggaa gaagatgaag
     2941 aagaaacaga tgatagtgac acttgggaac ccccacgaca tgtgaagcgg aagctttcta
     3001 aatcggatga ctgaaatcta cttaaaattc tgaaggagaa taagttcttc aattcaagat
     3061 gtctgaatta ctgtgaatgg gcccaaccaa tccttgatga cactgagaat gctttggggc
     3121 atacatactt tcaaaacaga atccaatatc caaaagaaat ggagctccat gttgtgccaa
     3181 agtcaaactg ctgcagtcgg gggcggttct gcaatgtaaa tagagcgcta attaaaacaa
     3241 acagactgta aaagtgaaat tttattctga caggatgcaa accttgtgaa tctttgactt
     3301 tctaaggggt taatgaccac tagagcttgt cctcacctcg actccagcat acagctctgt
     3361 aagacaggct gtattacctg tattctttga catgtgatta agcttacagc tttgagtgac
     3421 caaacatttt acagagtaaa agttgttaga aatgggagag gagaaccaaa ccctactttc
     3481 tgtgtcttat ttttcaggcc ctcaccaaat taaaagttgt acatgggctt acacagtttg
     3541 cagtgtaaaa gcagcctgtg cctgttatgt taggacagaa agacctgtgg cttgctggcc
     3601 tttatgacga gaccctccac tgaacactca tataaaccag tttctacttg tgcacttgtg
     3661 gggcttctct ttgtcagaat ccgatttgct ttttactaag ctgaagatac taccccagca
     3721 ggagaaggaa ctcagtaggg aacactctaa acatgttcca aacatgtgag agtccatagt
     3781 gaaatacatg tggtgtgttc tcaccggcgt gggactcagg aaggccagac agtctcaggt
     3841 tggattttgc aggaattacc ttttcatgaa gttgtacctt atgtaacaat ttcagtgaac
     3901 agaggggaaa aaaaattgga acctagcaag ttaaaaattt ccttttgatg taagaatcag
     3961 ggcgtgttag cggtaactgt gctgcagcag aagacagagt tcctactgac ttgtaacaga
     4021 ctggtgctga cgttcgtgct gggaaggacc ctttctgttg tgatcatagg accacttttc
     4081 aaactgtgct ttcctcacag aacaaaattt ttagttttat tagatttgga tttaaaattt
     4141 ttttgaatga tcacacatag tgggtttggc cagttcatct ttttctaact taatgaataa
     4201 taaatactaa gctcttggtt taatgtttgt cagctaatga gagatgttat gaaaaagcct
     4261 tgaatatgca tgctgctttc atttttataa actttttatt ttttaactat agctttatta
     4321 gcaattccca aatgctgcaa tttgctgatt tcttcactca gacagctggc tttgtgggcg
     4381 gctttttcat actactgtta actttttgaa aacgaagtga tgtaaagact gtaacaattg
     4441 aatgcactaa gctgtttttc ttttacacat ttaaaaactt cttaaagtac tctgtattat
     4501 aatgattaaa ttgctccctt tttaaaacca
//
