LOCUS       NM_134409                634 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus zymogen granule protein 16 (Zg16), mRNA.
ACCESSION   NM_134409
VERSION     NM_134409.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 634)
  AUTHORS   Bergstrom,J.H., Birchenough,G.M., Katona,G., Schroeder,B.O.,
            Schutte,A., Ermund,A., Johansson,M.E. and Hansson,G.C.
  TITLE     Gram-positive bacteria are held at a distance in the colon mucus by
            the lectin-like protein ZG16
  JOURNAL   Proc Natl Acad Sci U S A 113 (48), 13833-13838 (2016)
   PUBMED   27849619
REFERENCE   2  (bases 1 to 634)
  AUTHORS   Kumazawa-Inoue,K., Mimura,T., Hosokawa-Tamiya,S., Nakano,Y.,
            Dohmae,N., Kinoshita-Toyoda,A., Toyoda,H. and Kojima-Aikawa,K.
  TITLE     ZG16p, an animal homolog of beta-prism fold plant lectins,
            interacts with heparan sulfate proteoglycans in pancreatic zymogen
            granules
  JOURNAL   Glycobiology 22 (2), 258-266 (2012)
   PUBMED   21948871
  REMARK    GeneRIF: ZG16p, an animal homolog of beta-prism fold plant lectins,
            interacts with heparan sulfate proteoglycans in pancreatic zymogen
            granules.
REFERENCE   3  (bases 1 to 634)
  AUTHORS   Zhou,Y.B., Cao,J.B., Yang,H.M., Zhu,H., Xu,Z.G., Wang,K.S.,
            Zhang,X., Wang,Z.Q. and Han,Z.G.
  TITLE     hZG16, a novel human secreted protein expressed in liver, was
            down-regulated in hepatocellular carcinoma
  JOURNAL   Biochem Biophys Res Commun 355 (3), 679-686 (2007)
   PUBMED   17307141
REFERENCE   4  (bases 1 to 634)
  AUTHORS   Braun,M. and Thevenod,F.
  TITLE     Photoaffinity labeling and purification of ZG-16p, a high-affinity
            dihydropyridine binding protein of rat pancreatic zymogen granule
            membranes that regulates a K(+)-selective conductance
  JOURNAL   Mol Pharmacol 57 (2), 308-316 (2000)
   PUBMED   10648640
REFERENCE   5  (bases 1 to 634)
  AUTHORS   Kleene,R., Dartsch,H. and Kern,H.F.
  TITLE     The secretory lectin ZG16p mediates sorting of enzyme proteins to
            the zymogen granule membrane in pancreatic acinar cells
  JOURNAL   Eur J Cell Biol 78 (2), 79-90 (1999)
   PUBMED   10099930
REFERENCE   6  (bases 1 to 634)
  AUTHORS   Cronshagen,U., Voland,P. and Kern,H.F.
  TITLE     cDNA cloning and characterization of a novel 16 kDa protein located
            in zymogen granules of rat pancreas and goblet cells of the gut
  JOURNAL   Eur J Cell Biol 65 (2), 366-377 (1994)
   PUBMED   7720729
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AB095177.1 and CF249177.1.
            
            On Mar 11, 2009 this sequence version replaced NM_134409.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Z30584.1, BF522162.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-477               AB095177.1         1-477
            478-634             CF249177.1         450-606
FEATURES             Location/Qualifiers
     source          1..634
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q37"
     gene            1..634
                     /gene="Zg16"
                     /gene_synonym="Zg-16p; Zg16p"
                     /note="zymogen granule protein 16"
                     /db_xref="GeneID:171449"
                     /db_xref="RGD:620346"
     exon            1..24
                     /gene="Zg16"
                     /gene_synonym="Zg-16p; Zg16p"
                     /inference="alignment:Splign:2.1.0"
     exon            25..86
                     /gene="Zg16"
                     /gene_synonym="Zg-16p; Zg16p"
                     /inference="alignment:Splign:2.1.0"
     CDS             32..535
                     /gene="Zg16"
                     /gene_synonym="Zg-16p; Zg16p"
                     /note="zymogen granule membrane protein 16; secretory
                     lectin ZG16"
                     /codon_start=1
                     /product="zymogen granule membrane protein 16 precursor"
                     /protein_id="NP_599236.2"
                     /db_xref="GeneID:171449"
                     /db_xref="RGD:620346"
                     /translation="MLAIALLVLLCASASANSIQSRSSSYSGEYGGKGGKRFSHSGNQ
                     LDGPITAIRIRVNRYYIIGLQVRYGTVWSDYVGGNQGDLEEIFLHPGESVIQVSGKYK
                     SYVKQLIFVTDKGRYLPFGKDSGTSFNAVPLHPNTVLRFISGRSGSAIDAISLHWDTY
                     PSHCNTC"
     exon            87..219
                     /gene="Zg16"
                     /gene_synonym="Zg-16p; Zg16p"
                     /inference="alignment:Splign:2.1.0"
     exon            220..632
                     /gene="Zg16"
                     /gene_synonym="Zg-16p; Zg16p"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcatctgcaa ctactagggg aaagcctcag gatgttggcc attgccctct tagtccttct
       61 ctgtgcctcg gcgtctgcta attccattca gtccaggtcc tcctcttaca gtggagagta
      121 tggcggtaaa ggaggaaagc gattctctca ctctggcaac cagctggacg gccccatcac
      181 tgccatccgg atccgtgtca acagatacta cataataggt ctccaggtgc gctacggcac
      241 agtgtggagt gactatgtgg gtggcaacca gggagacctg gaggagatct ttctgcaccc
      301 cggggaatct gtgatccagg tgtctggcaa gtacaaatct tatgtgaagc agctgatctt
      361 cgtgacagac aaaggccgct acctgccttt tggaaaagac tcaggcacaa gtttcaacgc
      421 tgttcccttg caccccaaca ctgtcctccg tttcattagt ggccgatctg gctctgccat
      481 agatgctatc agcctgcact gggataccta ccctagccac tgcaacactt gttgaaaccc
      541 accatcctct gctgtggtgg gtatgagaac tcccttatca acaagcccca ggcaaacatg
      601 caaatagctt aataaaagga tatggttaaa gaaa
//
