LOCUS       NM_001107952            6457 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus zinc finger FYVE-type containing 9 (Zfyve9),
            mRNA.
ACCESSION   NM_001107952 XM_001060706 XM_001060761 XM_233341
VERSION     NM_001107952.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6457)
  AUTHORS   Yu W, Du Y, Zou Y, Wang X, Stephani U and Lu Y.
  TITLE     Smad anchor for receptor activation contributes to seizures in
            temporal lobe epilepsy
  JOURNAL   Synapse 71 (3) (2017)
   PUBMED   28035691
  REMARK    GeneRIF: Our results demonstrate that SARA/Smad3 pathway
            contributes to mechanism of seizure
REFERENCE   2  (bases 1 to 6457)
  AUTHORS   Arias CI, Siri SO and Conde C.
  TITLE     Involvement of SARA in Axon and Dendrite Growth
  JOURNAL   PLoS One 10 (9), e0138792 (2015)
   PUBMED   26405814
  REMARK    GeneRIF: Findings suggest a significant contribution of SARA to key
            aspects of neuronal development, including neurite formation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6457)
  AUTHORS   Tao YY, Cui HY and Liu CH.
  TITLE     [Dynamic characteristics of SARA during liver fibrogenesis in rats]
  JOURNAL   Zhonghua Gan Zang Bing Za Zhi 14 (12), 909-913 (2006)
   PUBMED   17196135
  REMARK    GeneRIF: SARA was mainly expressed in the liver interstitial cells,
            and it was negatively correlated with liver fibrosis formation.
REFERENCE   4  (bases 1 to 6457)
  AUTHORS   Chong PA, Ozdamar B, Wrana JL and Forman-Kay JD.
  TITLE     Disorder in a target for the smad2 mad homology 2 domain and its
            implications for binding and specificity
  JOURNAL   J Biol Chem 279 (39), 40707-40714 (2004)
   PUBMED   15231848
REFERENCE   5  (bases 1 to 6457)
  AUTHORS   Shi Y and Massague J.
  TITLE     Mechanisms of TGF-beta signaling from cell membrane to the nucleus
  JOURNAL   Cell 113 (6), 685-700 (2003)
   PUBMED   12809600
  REMARK    Review article
REFERENCE   6  (bases 1 to 6457)
  AUTHORS   Panopoulou E, Gillooly DJ, Wrana JL, Zerial M, Stenmark H, Murphy C
            and Fotsis T.
  TITLE     Early endosomal regulation of Smad-dependent signaling in
            endothelial cells
  JOURNAL   J Biol Chem 277 (20), 18046-18052 (2002)
   PUBMED   11877415
REFERENCE   7  (bases 1 to 6457)
  AUTHORS   Tsukazaki T, Chiang TA, Davison AF, Attisano L and Wrana JL.
  TITLE     SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta
            receptor
  JOURNAL   Cell 95 (6), 779-791 (1998)
   PUBMED   9865696
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474008.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001060761.1, XM_001060706.1, XM_233341.4.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..6457
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q34"
     gene            1..6457
                     /gene="Zfyve9"
                     /note="zinc finger FYVE-type containing 9"
                     /db_xref="GeneID:313477"
                     /db_xref="RGD:1310856"
     exon            1..324
                     /gene="Zfyve9"
                     /inference="alignment:Splign:2.1.0"
     exon            325..411
                     /gene="Zfyve9"
                     /inference="alignment:Splign:2.1.0"
     exon            412..517
                     /gene="Zfyve9"
                     /inference="alignment:Splign:2.1.0"
     CDS             448..4644
                     /gene="Zfyve9"
                     /note="zinc finger, FYVE domain containing 9"
                     /codon_start=1
                     /product="zinc finger FYVE domain-containing protein 9"
                     /protein_id="NP_001101422.1"
                     /db_xref="GeneID:313477"
                     /db_xref="RGD:1310856"
                     /translation="MENYFQAEAYNLDKVLDEFEQNEDETVSPTLLDTKWNKILDSSS
                     HPLSFNPALANVNEPTISNETGPQRKIFSLAGSAPLTREGKGPCANGQDGSLNPEIDT
                     MWIDENAVAEDQLIKRNYNQDDQFSAVEVGEEKRGSLTCLPDEKNVLVVAVMHNCDKR
                     TLQSDLQDCNNYNSQSLMDSFSCSLDNETRQTDQFSFSMNGSAEKGINSEKQMDALNK
                     PKSERDSLNHLCAASANSATSISSSSQLKDNENVGRDPSTSTATSLAINTSQGMDGGP
                     AIKKQEDYMPDEDLSGANSSSRTDLGSSNSFSHSREELLTKTEPAEERTAEDPLPSGL
                     SLNLKPDTPALCGRDNCEPSSDCLVSSETRTDGDGGKDSQTTHWDSAKLNEVDDRQGS
                     EENQVVLQISQPEDPQSAGECVRMADSDLDFKGTCLNESEGYDFSTVSDAPAANSLSN
                     SCDSYGMQSPIVSFVPKTLPSKEDSVTEEKEIEESKSECYSNLYEQRGNENTEGNGLL
                     LNSTGTIMKKNYLHNFCSQIPSVLGQSSPKIANLQSISVPFGGARPKQPSNLKLQIPK
                     PLSDHLQNDLPANNGNNSKNKNDILGKAKLGENSAVSACSATLGNISVTDTNGEHLES
                     FEADISSRPCLALSPDSPDNDLRAGQFGISARKPFTTLGEVAPVWVPDSQAPNCMKCE
                     ARFTFTKRRHHCRACGKVFCASCCSLKCKLLYMDRKEARVCVICHSVLMNAQAWENMM
                     SASSQSPNPNNPAEYCSTIPPLQQAQASGALSSPPPTVMVPVGVLKHPGTEVPQPREQ
                     RRVWFADGILPNGEVADAAKLTMNGTSSAGTLAVSHDPVKPVATSPLPAEADVSLFSG
                     SITQVGSPVGSAMNLIPEDGLPPILISTGVKGDYAVEEKPSQISVMQQLEDGGPDPLV
                     FVLNANLLSMVKIVNYVNRKCWCFTTKGMHAVGQSEIVILLQCLPDEKCLPKDIFNHF
                     VQLYRDALAGSVVGSLGHSFFSQSFLGSKEHGGFLYMTSTHQSLQDLLLPTPPYLFGI
                     LIQKWETPWAKVFPIRLMLRLGAEYRLYPCPLFSVRFRKPLFGETGHTIMNLLADFRN
                     YQYTLPGVQGLVVDMEVRKTSIKIPSNRYNEMMKAMNKSNEHVLAGGACFNEKADSHL
                     VCVQNDDGNYQTQAISIHNQPRKVTGASFFVFSGALKSSSGYLAKSSIVEDGVMVQIT
                     AENMDSLRQALREMKDFTITCGKADAEDPQEQIHIQWVDDDKTVNKGVVSPIDGKSME
                     SITNVKIFHGSEYKANGKVIRWTEVFFLENDDHRTCLSDPADHSRLTEHVAKAFCLAL
                     CPHLKLLKEDGMTKLGLRVTLDSDQVGYQAGSNGQPLPSQYMKDLDSALVPVIHGGAC
                     QLSEGPVGIELIFYILENIA"
     exon            518..2544
                     /gene="Zfyve9"
                     /inference="alignment:Splign:2.1.0"
     exon            2545..2644
                     /gene="Zfyve9"
                     /inference="alignment:Splign:2.1.0"
     exon            2645..2821
                     /gene="Zfyve9"
                     /inference="alignment:Splign:2.1.0"
     exon            2822..2991
                     /gene="Zfyve9"
                     /inference="alignment:Splign:2.1.0"
     exon            2992..3112
                     /gene="Zfyve9"
                     /inference="alignment:Splign:2.1.0"
     exon            3113..3235
                     /gene="Zfyve9"
                     /inference="alignment:Splign:2.1.0"
     exon            3236..3391
                     /gene="Zfyve9"
                     /inference="alignment:Splign:2.1.0"
     exon            3392..3616
                     /gene="Zfyve9"
                     /inference="alignment:Splign:2.1.0"
     exon            3617..3699
                     /gene="Zfyve9"
                     /inference="alignment:Splign:2.1.0"
     exon            3700..3804
                     /gene="Zfyve9"
                     /inference="alignment:Splign:2.1.0"
     exon            3805..3955
                     /gene="Zfyve9"
                     /inference="alignment:Splign:2.1.0"
     exon            3956..4036
                     /gene="Zfyve9"
                     /inference="alignment:Splign:2.1.0"
     exon            4037..4199
                     /gene="Zfyve9"
                     /inference="alignment:Splign:2.1.0"
     exon            4200..4305
                     /gene="Zfyve9"
                     /inference="alignment:Splign:2.1.0"
     exon            4306..4482
                     /gene="Zfyve9"
                     /inference="alignment:Splign:2.1.0"
     exon            4483..6457
                     /gene="Zfyve9"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcggccgccg cagtcccggc gccgtagcgg gacgtggggt ccagggggcg ctgtggccca
       61 gcggcgcggg cggctgaagc ggccaccgcg gcgcccgagg cttcgccgag cccgtccgcc
      121 tgcagcgcct cggtcgtccc gccgtaagct gcgcccccgg ccgcgctccc ccagccccgc
      181 gtggctgagg cgactggagc ggcgctgggc ctcgtccccg gccgcagaaa ccgcagcccc
      241 ctcaggagtg cgaggcttcg cggcggagcc ctgctgtgga ggaggctctc ggctgagtga
      301 cgacccccgg gccatggaga ggcggatcaa agaagacatt ctgggtcagc agtactggct
      361 ggcgcagcag gcatcatgag caagcacaga gaaggctgct tgaggggaca ggtttaaata
      421 agtctcttca gcagtgtttc ctccctgatg gagaattact tccaagcaga agcttacaac
      481 ctggacaagg tattagatga atttgaacaa aatgaagatg aaacagtttc tcctacttta
      541 ttggatacaa agtggaataa gattttagat tcctcttctc atccattgtc ttttaaccct
      601 gcattagcca atgtgaatga acctacaatt tctaatgaga caggaccaca gcggaaaatc
      661 ttttctcttg ctggctcagc tccccttaca agggagggaa aaggtccctg tgctaacgga
      721 caggacggta gtctaaatcc agagattgac acgatgtgga ttgatgaaaa tgctgtggca
      781 gaagaccaac taattaagag aaactacaat caggatgatc aatttagtgc cgttgaagtg
      841 ggagaggaga aacgtgggag cctcacttgt ctgccagacg agaagaatgt tctggttgta
      901 gctgtcatgc ataactgtga taaaaggaca ctgcaaagtg atttgcagga ttgtaataac
      961 tataatagtc aatccctcat ggattctttt agctgttcac tggataatga aactagacaa
     1021 actgatcaat ttagttttag tatgaatggg tccgcagaaa aaggtataaa ctcagagaaa
     1081 caaatggatg ctttgaataa accaaaatca gagagggatt ctcttaatca tctctgcgct
     1141 gcttcagcta acagtgcaac cagtatctct tcctcttcac aattaaagga caatgaaaat
     1201 gtaggtagag acccatctac atctacagct acaagcttag caattaatac atcccaggga
     1261 atggatggag ggcctgccat taaaaaacaa gaggattata tgcctgatga ggacctttct
     1321 ggcgcaaaca gctcttctag gacagatcta gggagctcaa actccttttc ccactcaagg
     1381 gaggagctct taacaaaaac agagccagca gaggagagga cagctgaaga ccccctccca
     1441 tctggtttat ctttgaatct caagccagat actcctgctt tatgtggaag ggacaattgc
     1501 gaaccatcct cagactgcct tgtgtctagt gagactagaa ctgatggaga tggaggtaag
     1561 gactctcaga cgactcactg ggactcagca aagctaaatg aggtggatga tcgccaagga
     1621 agtgaagaaa atcaagtggt tttacagatc agccaacctg aggaccctca gagtgcagga
     1681 gagtgtgtta gaatggcaga ttcagatcta gatttcaaag gaacttgctt gaatgaaagt
     1741 gaaggatatg atttctccac tgttagtgat gcaccagcag caaattctct gtctaatagt
     1801 tgtgattcct atggaatgca gagcccaatt gtatcttttg ttccaaagac tttaccctcc
     1861 aaagaagatt cagtaacaga agaaaaagaa atagaagaga gcaaatcaga atgctactca
     1921 aatctttatg aacagagagg aaatgagaac acagaaggga atggactgct tttaaacagc
     1981 actggaacta taatgaagaa aaattattta cataatttct gtagtcaaat cccatctgta
     2041 ctcgggcaat cttcccccaa gatagcaaac ctgcagtcta ttagtgttcc ttttggtggt
     2101 gcaagaccca agcaaccttc taatcttaaa cttcagattc caaagccatt atcagaccat
     2161 ttacaaaatg accttcctgc aaacaatgga aataatagta aaaacaaaaa tgatattctt
     2221 gggaaagcaa aactagggga aaactcagca gtcagtgcgt gcagtgcaac tttgggaaac
     2281 atctctgtga ctgatacaaa tggggaacat ttagaaagtt tcgaggctga catctccagt
     2341 agaccatgcc ttgcattatc tccagatagt ccagataatg atctcagagc tggtcaattt
     2401 ggaatttctg caagaaagcc atttaccacc ctgggtgagg tggcaccagt atgggtacca
     2461 gactcccagg ctccgaactg catgaagtgt gaagctcggt ttacattcac caaaaggagg
     2521 catcattgca gagcatgtgg gaaggttttc tgtgcttcct gctgcagcct gaaatgcaaa
     2581 ctgctgtaca tggatagaaa ggaagctcga gtgtgtgtca tctgtcactc agtgctaatg
     2641 aacgctcaag cctgggagaa catgatgagt gcctcaagcc agagccctaa ccctaacaat
     2701 cctgctgaat actgttctac tatccctccc ttgcagcaag ctcaggcctc aggagccctg
     2761 agctctccac ctcccactgt gatggtacct gtgggagttt taaagcaccc tggaacagaa
     2821 gtgcctcagc ccagagagca gaggagagtt tggtttgctg atgggatttt acccaatgga
     2881 gaagttgctg atgcagccaa attaacaatg aatggaactt cctctgcagg aactctggct
     2941 gtgtcacatg acccagtcaa gcctgtagcc accagtcctc taccggcaga ggctgacgtt
     3001 tctctgttct ctgggagcat tactcaggtt ggaagtcctg ttggaagtgc aatgaacctt
     3061 attcctgaag atggccttcc tcccatcctc atctccacgg gtgtgaaagg agattatgct
     3121 gtggaagaga aaccatcaca gatttcagtc atgcagcaac tggaggatgg tggccctgac
     3181 ccacttgtgt ttgttttaaa tgcaaattta ttgtcaatgg ttaaaattgt aaattatgtg
     3241 aacaggaagt gctggtgttt tactaccaaa ggaatgcatg ctgtgggtca gtctgagata
     3301 gtcattttgc tacagtgtct accagatgag aaatgtttgc ccaaggacat ctttaatcat
     3361 tttgtacaac tttaccggga tgcactggct gggagtgttg tgggcagcct gggacattct
     3421 ttcttcagtc agagcttcct gggcagtaaa gagcacggcg ggttcctgta catgacctct
     3481 acccaccagt cactgcaaga cctgctgctt ccaacacctc cttatctgtt tgggattctc
     3541 atccagaaat gggagacccc ttgggccaaa gtgtttccta ttcgactcat gttaagactt
     3601 ggagctgagt atcgacttta cccctgtcca ctgttcagtg tcagatttcg gaagccattg
     3661 ttcggagaaa ctgggcatac catcatgaat cttctagcag acttccgaaa ttaccagtac
     3721 actttgccag gtgtccaagg tttggtggtt gatatggaag ttcggaaaac aagcatcaaa
     3781 attcccagca acagatacaa tgagatgatg aaagccatga acaaatccaa tgagcacgtc
     3841 ctggcaggag gtgcctgctt caatgaaaag gcagattctc atcttgtgtg tgtacagaac
     3901 gatgatggga actatcagac ccaggccatc agtattcaca atcagcccag gaaagtgact
     3961 ggtgccagct tcttcgtgtt cagtggcgca ctgaagtcct cttcagggta ccttgccaag
     4021 tccagtattg tagaagatgg cgttatggtc cagatcactg cagagaacat ggattccttg
     4081 aggcaggcac tgcgggagat gaaggacttt accatcactt gtgggaaggc agatgcagag
     4141 gacccccagg aacagatcca catccagtgg gtggacgacg acaagacagt taacaaaggt
     4201 gtggtgagtc ctatagatgg gaagtccatg gaatctataa caaatgtgaa aatattccat
     4261 gggtcagagt ataaagccaa tggaaaagtc atcagatgga cagaggtttt cttcctagag
     4321 aacgatgacc accgtacctg cctgagtgac cctgcagatc acagcagact gaccgagcac
     4381 gtcgccaagg cattctgcct ggccctctgc ccccacctga agcttttaaa agaagacgga
     4441 atgacaaaac tgggactccg tgtgacgctt gactcagatc aggttggcta tcaagcaggg
     4501 agcaatggac agcccctccc ctcgcagtac atgaaggatc tggacagtgc cttggtgcct
     4561 gtcatccatg gaggagcctg ccagctcagc gagggcccgg tcggcatcga gctcatcttt
     4621 tacatcctgg agaacatcgc gtagatggca ctccgtctgt tctgttcaga cctgcagcag
     4681 cagtcatatc caaaccattt gcactttaaa actggaagat taagcttttg ttaacactgt
     4741 taggagggag ggtatggggt gggagtagga cttaggggaa aaggggtggg gagggtggtt
     4801 gggggacaga tgatccatga ttctaagtct tctatgcatt ctccaagaag acctgggcag
     4861 cttcctactg cacaacagat atgctatctt tgcagctaac tcccttctgt tactgtctag
     4921 acaagaattc tgctcctctc ttacgatgac ttccggtcat gtgctcagat gaatgctcat
     4981 atgggtacag ccatcaccaa ggtcacggtg ggggagaaag gaaataaaca atgaatcatc
     5041 acttttgcac tttctgtaca gagttgacaa ataacgaatg ccatgcttat ggtcctggtt
     5101 acaccccagc gttgatcaag gagaattcat gtttatttgt tcagattact aattgaatca
     5161 aaccaaaggg gttcgggtct gtttgccacc ggagggcatt tggaaagaga atctgagtga
     5221 cagctagcca aggacaccca gggcattttt atttactgta caacagaagt atttttaaag
     5281 aacttttact aagaaatctc ttagaactcc aggaaaatta tacctattta aaaaaagtgt
     5341 cctcttttct acagccccat gtacacactc acacactaac aactttgccc atttagtttg
     5401 tcagtgctta tctttcccct cctctataaa actgaggtat ttcagactaa ggtgcataca
     5461 acacagcccc tgagcccttt acagtagaca tttattcctt gtccaaacag gactaaagtc
     5521 aaggtcacag tgtctggagg ctctaacctc actcctgcta gaacctttga gagccattct
     5581 tcaacagaga acttccaggc tagggtcaga tgctgcacat agctttaggc ttggcttcct
     5641 ctccttgtgc catggatatt gttttgtgag tacaggccct cacatttgtt tggttttagc
     5701 agaaaatacc tcatttgagt ttgcattctt ggccagaatc ccttgatacc catctgcctt
     5761 tcagagacag tggcagctct catcattgtt cagcgtctag cgtccctgtg cgtttgccct
     5821 ttagtggtga ctgatatatg cagagtactt tccatctatg caaataccct gctccccaaa
     5881 gctcccctta ggtcagcacc accgatgttt cggcctgcac tgaccttttc ccaggactgc
     5941 tgtaaggtag ctttttagtt ccggcatgcc ctttctttac cagctgggtt taataatctc
     6001 aaaataagca agcccaccct tccctctttg tcctgttatt tgtgtgatct tcatgttggt
     6061 cctgtggagt tctcctgtct tcatcttgta ctcaggtggt ctcatctttg gctgagttga
     6121 acaacttcaa gctggttcat gcaccctttc cgtgacatcc ttaggtttaa tccttcctgt
     6181 ctagcctaac aagaaactcc aggcaaacct tgcacccctg ctccaagctt ggaatcactt
     6241 tatctccaag cagcccttta actggagtac gggaaacaaa ggtctggttc actgaagaca
     6301 tatgtgatac tgattttttt tttatttttt ttgagacgcg ggttctttgc atagtcttgg
     6361 gtgtcctgga ctggctggcc ttgaactcac aagcgatctg cctgcctctg cttctgcctc
     6421 ccaagtgttg ggattaaagt tgtgtgccat catgctc
//
