LOCUS       NM_001106743            3821 bp    mRNA    linear   ROD 26-OCT-2024
DEFINITION  Rattus norvegicus zinc finger FYVE-type containing 1 (Zfyve1),
            transcript variant 1, mRNA.
ACCESSION   NM_001106743 XM_001056518 XM_216762
VERSION     NM_001106743.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3821)
  AUTHORS   Gao,G., Sheng,Y., Yang,H., Chua,B.T. and Xu,L.
  TITLE     DFCP1 associates with lipid droplets
  JOURNAL   Cell Biol Int 43 (12), 1492-1504 (2019)
   PUBMED   31293035
REFERENCE   2  (bases 1 to 3821)
  AUTHORS   Li,D., Zhao,Y.G., Li,D., Zhao,H., Huang,J., Miao,G., Feng,D.,
            Liu,P., Li,D. and Zhang,H.
  TITLE     The ER-Localized Protein DFCP1 Modulates ER-Lipid Droplet Contact
            Formation
  JOURNAL   Cell Rep 27 (2), 343-358 (2019)
   PUBMED   30970241
REFERENCE   3  (bases 1 to 3821)
  AUTHORS   Vicinanza,M., Korolchuk,V.I., Ashkenazi,A., Puri,C., Menzies,F.M.,
            Clarke,J.H. and Rubinsztein,D.C.
  TITLE     PI(5)P regulates autophagosome biogenesis
  JOURNAL   Mol Cell 57 (2), 219-234 (2015)
   PUBMED   25578879
REFERENCE   4  (bases 1 to 3821)
  AUTHORS   Nanao,T., Koike,M., Yamaguchi,J., Sasaki,M. and Uchiyama,Y.
  TITLE     Cellular localization and tissue distribution of endogenous DFCP1
            protein
  JOURNAL   Biomed Res 36 (2), 121-133 (2015)
   PUBMED   25876663
REFERENCE   5  (bases 1 to 3821)
  AUTHORS   Dooley,H.C., Razi,M., Polson,H.E., Girardin,S.E., Wilson,M.I. and
            Tooze,S.A.
  TITLE     WIPI2 links LC3 conjugation with PI3P, autophagosome formation, and
            pathogen clearance by recruiting Atg12-5-16L1
  JOURNAL   Mol Cell 55 (2), 238-252 (2014)
   PUBMED   24954904
REFERENCE   6  (bases 1 to 3821)
  AUTHORS   Hayashi-Nishino,M., Fujita,N., Noda,T., Yamaguchi,A., Yoshimori,T.
            and Yamamoto,A.
  TITLE     A subdomain of the endoplasmic reticulum forms a cradle for
            autophagosome formation
  JOURNAL   Nat Cell Biol 11 (12), 1433-1437 (2009)
   PUBMED   19898463
REFERENCE   7  (bases 1 to 3821)
  AUTHORS   Hendrickx,A., Beullens,M., Ceulemans,H., Den Abt,T., Van Eynde,A.,
            Nicolaescu,E., Lesage,B. and Bollen,M.
  TITLE     Docking motif-guided mapping of the interactome of protein
            phosphatase-1
  JOURNAL   Chem Biol 16 (4), 365-371 (2009)
   PUBMED   19389623
REFERENCE   8  (bases 1 to 3821)
  AUTHORS   Krugmann,S., Anderson,K.E., Ridley,S.H., Risso,N., McGregor,A.,
            Coadwell,J., Davidson,K., Eguinoa,A., Ellson,C.D., Lipp,P.,
            Manifava,M., Ktistakis,N., Painter,G., Thuring,J.W., Cooper,M.A.,
            Lim,Z.Y., Holmes,A.B., Dove,S.K., Michell,R.H., Grewal,A.,
            Nazarian,A., Erdjument-Bromage,H., Tempst,P., Stephens,L.R. and
            Hawkins,P.T.
  TITLE     Identification of ARAP3, a novel PI3K effector regulating both Arf
            and Rho GTPases, by selective capture on phosphoinositide affinity
            matrices
  JOURNAL   Mol Cell 9 (1), 95-108 (2002)
   PUBMED   11804589
REFERENCE   9  (bases 1 to 3821)
  AUTHORS   Ridley,S.H., Ktistakis,N., Davidson,K., Anderson,K.E., Manifava,M.,
            Ellson,C.D., Lipp,P., Bootman,M., Coadwell,J., Nazarian,A.,
            Erdjument-Bromage,H., Tempst,P., Cooper,M.A., Thuring,J.W.,
            Lim,Z.Y., Holmes,A.B., Stephens,L.R. and Hawkins,P.T.
  TITLE     FENS-1 and DFCP1 are FYVE domain-containing proteins with distinct
            functions in the endosomal and Golgi compartments
  JOURNAL   J Cell Sci 114 (Pt 22), 3991-4000 (2001)
   PUBMED   11739631
REFERENCE   10 (bases 1 to 3821)
  AUTHORS   Cheung,P.C., Trinkle-Mulcahy,L., Cohen,P. and Lucocq,J.M.
  TITLE     Characterization of a novel phosphatidylinositol
            3-phosphate-binding protein containing two FYVE fingers in tandem
            that is targeted to the Golgi
  JOURNAL   Biochem J 355 (Pt 1), 113-121 (2001)
   PUBMED   11256955
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473982.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_216762.4, XM_001056518.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA5760383, SAMEA5760389
                              [ECO:0000350]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..3821
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q31"
     gene            1..3821
                     /gene="Zfyve1"
                     /note="zinc finger FYVE-type containing 1"
                     /db_xref="GeneID:299188"
                     /db_xref="RGD:1307795"
     exon            1..167
                     /gene="Zfyve1"
                     /inference="alignment:Splign:2.1.0"
     exon            168..662
                     /gene="Zfyve1"
                     /inference="alignment:Splign:2.1.0"
     CDS             180..2513
                     /gene="Zfyve1"
                     /note="isoform 1 is encoded by transcript variant 1; zinc
                     finger FYVE domain-containing protein 1; zinc finger, FYVE
                     domain containing 1"
                     /codon_start=1
                     /product="zinc finger FYVE domain-containing protein 1
                     isoform 1"
                     /protein_id="NP_001100213.1"
                     /db_xref="GeneID:299188"
                     /db_xref="RGD:1307795"
                     /translation="MSAQTSLAEKGLNPGLMCQESYACSGTDEAVFECDECCSLQCLR
                     CEEELHRQERLRNHERIRLKAGHVPYCDPCKGPNGHSPGVRQRAAVRCQTCKINLCLE
                     CQKRTHSGGNKRRHPVTVYHVSKVQESLEGEEMDEETKRRKMTERVVSFLLVDENEEI
                     QVTNEEDFIRKLDCKPDQHLKVVSIFGNTGDGKSHTLNHTFFHGREVFKTSPAQESCT
                     VGVWAAHDPVHKVAVIDTEGLLGATVNLSQRTRLLLKVLAISDLVIYRTHADRLHNDL
                     FKFLGDASEAYLKHFTKELKATTARCGLDVPLSTLGPAVIIFHETVHTQLLGSDHPSE
                     APEKLIQDRFRKLGRFPEAFSSIHYKGTRTYNPPTDFSGLRRALEQLLENNTTRSPRH
                     PGVIFKALKALSDRFSGEIPDDQMAHSSFFPDEYFTCSSLCLSCGAGCKNSMNHGKEG
                     VPHEAKSRCRYSHQYDNRVYTCKACYERGKEVSVVPKTSASTDSPWMGLAKYAWSGYV
                     IECPNCGVVYRSRQYWFGNQDPVDTVVRTEIVHVWPGTDAFLKDNNNAAQRLLDGMNF
                     MAQSVSELSLGPTKAVTSWLTDQIAPAYWRPNSQILSCNQCATSFKDNDTKHHCRACG
                     EGFCDSCSSKTRPVPERGWGPAPVRVCDNCYDARNVQLDVAEAQADDEGGTLIARKVG
                     EAVQNTLGAVVTAIDIPLGLVKDAARPAYWVPDHEILHCHNCRKEFSVKLSKHHCRAC
                     GQGFCDECSHGRRAVPSRGWDHPVRVCFNCNKKPGDL"
     exon            663..1167
                     /gene="Zfyve1"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1382
                     /gene="Zfyve1"
                     /inference="alignment:Splign:2.1.0"
     exon            1383..1489
                     /gene="Zfyve1"
                     /inference="alignment:Splign:2.1.0"
     exon            1490..1598
                     /gene="Zfyve1"
                     /inference="alignment:Splign:2.1.0"
     exon            1599..1696
                     /gene="Zfyve1"
                     /inference="alignment:Splign:2.1.0"
     exon            1697..1814
                     /gene="Zfyve1"
                     /inference="alignment:Splign:2.1.0"
     exon            1815..1985
                     /gene="Zfyve1"
                     /inference="alignment:Splign:2.1.0"
     exon            1986..2166
                     /gene="Zfyve1"
                     /inference="alignment:Splign:2.1.0"
     exon            2167..2280
                     /gene="Zfyve1"
                     /inference="alignment:Splign:2.1.0"
     exon            2281..3821
                     /gene="Zfyve1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctgattcca actgacaaca agagaggagg aagcctggga ggcagcagag gaggaggggg
       61 cggagatgga actgaggatg gatccaccgg ggccctagag cagcccaggt cccgtcgcca
      121 atccgcgtcc ccccacacac cgccttgcct tggccgagct gctccggaga gtctcagtta
      181 tgagtgccca gacttcctta gcagagaagg gcctaaatcc ggggctcatg tgccaggaga
      241 gttatgcttg cagcgggact gatgaagctg tcttcgaatg cgatgagtgt tgtagtttgc
      301 agtgtctccg ctgtgaggaa gaactccacc ggcaggagcg ccttcgaaac catgagcgga
      361 taagactcaa agctggtcat gtcccttact gtgacccctg caagggcccc aacgggcatt
      421 caccaggcgt caggcagagg gcagccgtga ggtgccagac ctgcaagatc aacctgtgtc
      481 tggagtgcca gaagaggact cattcagggg gtaacaagag aagacacccc gttactgtgt
      541 accatgtcag taaggtccag gagtctctgg agggtgaaga gatggatgag gagaccaaga
      601 ggaggaagat gacagagagg gttgtgagct tcctcctggt agatgaaaac gaagagatcc
      661 aggtaacaaa tgaagaggac tttattagga aattggactg taagcctgac cagcatctca
      721 aggtggtttc catttttgga aatactggtg atggaaagtc ccataccctc aaccacactt
      781 tcttccatgg ccgagaagtc ttcaaaacgt cccctgctca ggagtcctgc actgtgggag
      841 tgtgggcagc ccatgaccca gtccataagg tagcagtgat agacacagaa gggctcttgg
      901 gggccaccgt gaatctgagc cagaggacac ggctgctgct aaaggtcctg gccatctcag
      961 acttggtcat ctatcgaact catgcagacc ggctgcacaa tgacctcttc aaattccttg
     1021 gggatgcctc ggaagcttac ctgaagcact ttaccaagga actcaaggct accactgcac
     1081 gctgtggcct ggatgtcccc ttatccactc tgggccctgc agtcattatt ttccacgaga
     1141 ctgtgcacac tcagcttctg ggttctgatc acccctcaga ggctcctgag aagctcatcc
     1201 aggaccggtt caggaagctg ggccgcttcc ctgaagcctt tagctccatt cattacaagg
     1261 gaacgaggac atacaatccc cccacagact tctctgggct tcggcgtgcc ctggaacagc
     1321 tgctagagaa caacactacg aggtctcctc ggcacccagg ggtcatcttc aaagccctga
     1381 aggcactaag tgaccgcttc agcggtgaga tccctgatga ccagatggcg cacagttcat
     1441 tttttccaga tgagtacttc acctgctcct cactctgcct cagctgtggg gcgggatgta
     1501 agaacagcat gaaccacggc aaggaagggg tgcctcatga agccaagagc cgttgtcggt
     1561 actcacacca gtatgacaac cgagtttata cctgcaaggc ctgctatgag agaggcaagg
     1621 aagtcagcgt ggtgcccaaa acatccgcct ccaccgactc tccctggatg ggtctggcga
     1681 agtatgcctg gtccgggtat gtgatcgaat gtcctaactg cggtgtggtc tatcggagcc
     1741 gccagtactg gtttgggaac caagatcctg tggatacagt agttcggaca gagattgtac
     1801 atgtgtggcc tggaacggat gcatttctga aggataacaa caatgctgcc cagcgtctgt
     1861 tggatgggat gaactttatg gcccagtcag tgtctgagct tagtcttgga cccactaagg
     1921 ctgtgacttc ttggctaacg gaccagatcg ctcctgccta ctggaggccc aactcccaga
     1981 tcctgagctg caaccagtgt gcgacatcct tcaaggacaa cgacaccaag catcactgcc
     2041 gggcctgtgg tgagggcttc tgtgacagct gttcatccaa gacccggcca gtgcccgaga
     2101 ggggctgggg acctgcgcct gtccgtgtgt gtgacaactg ctacgacgcc aggaatgtcc
     2161 agttagatgt ggctgaggcg caggcagatg atgaaggcgg aacgctgatc gccaggaagg
     2221 tgggcgaggc cgtgcagaac accttgggag ccgtggtgac agctattgac ataccactag
     2281 gcctggtgaa agatgctgcc aggccggcct actgggtgcc cgaccacgag atcctgcact
     2341 gccacaactg ccgcaaggag ttcagtgtca agctctccaa gcaccactgc cgagcctgcg
     2401 gacagggctt ctgcgacgag tgctcccatg gccgcagggc tgtgccctct cgaggctggg
     2461 accatccagt ccgagtctgc ttcaactgca ataaaaagcc tggtgacctt taaccccagt
     2521 tccctctcca ctccttcaca gttccttagg ttctcagggt tagaaacaag tctcactgag
     2581 gtaggccctc ctcctggtca cctggtgtgg tgtggtgtgg tgtgtgtgcc ccctcacatc
     2641 cctgggctat tttcctcagt ggaggtgagc ctggcggtag atccgaaggc atgaaaatcc
     2701 gaaggcatga accacctcag ggcaggggac ggagggaaca gctctcagta aagcagattg
     2761 gacaagagtc cattgcattt atttcagcta aaataataaa tccctctctc cattcatcca
     2821 cgtagagtgg atttggagtg ctcaagactg ttctgctttg aagacttacc ctggcctggc
     2881 ccacacaggg acagagtggc actgggagtc agtctttctc ctgaagcaag ccaggcttag
     2941 agtcaccttt tgctgcttct cccagagctt ggcagagtcc ttttctgccc cttctccctc
     3001 ctgctcccca gctgcctgat tggccggccg cctgggtctg aacctgctgc ttgaagcagt
     3061 gttggttctg gcttgttctg ggcagaggtc cggctcggtt ggtgtgtaag ctgctggtat
     3121 gtgtaagggg cagagggcag gcaggcaggc agggtcttga gacatagaag tgaaaacgca
     3181 ggtcctggca ggatatctgc tcctggatgc ttctgtctcc attaggtttt cttagaaggc
     3241 cataccctgc cccttagtca gagctcagct cctcacctct gctcctctga ggatttttat
     3301 tactcagtgt cttactctct gttcccatac ataaaacccc tctgtctgtt atggggggag
     3361 gggtgaccac gagaaacctt ccagggaaac agcacagaat ggactgttag ttgtgttttt
     3421 taaaaatata tataaatata taaataaata tttcaacaga tcataaggaa aaaacttctc
     3481 tttggttctt acaagagaaa tgaagtgaac aaatgtttct caaaaagagc ttggacatcc
     3541 tatcgatcat gactggaaga ctgttgtgct gaactcctgt ggggtggagt tcatcttcaa
     3601 tggccaaaaa aagaagaatt acagcagcgt tgttattgat tgaactgatg ggtgggtgga
     3661 gcctcgggaa gtgtgtgggt gggcagtcgt ccctggggtg tgtatccagc ggttagcctt
     3721 ggaatggatc ggtccttctc agatctgtcc tttctgcttc ccgaggccct gctctagaac
     3781 tgtgtcatca ctcaccacta taaaggactc ttctgctgag c
//
