LOCUS       NM_001008557            3396 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus zinc finger protein 667 (Zfp667), mRNA.
ACCESSION   NM_001008557 XM_218238
VERSION     NM_001008557.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3396)
  AUTHORS   Jiang,L., Wang,H., Shi,C., Liu,K., Liu,M., Wang,N., Wang,K.,
            Zhang,H., Wang,G. and Xiao,X.
  TITLE     ZNF667/Mipu1 is a novel anti-apoptotic factor that directly
            regulates the expression of the rat Bax gene in H9c2 cells
  JOURNAL   PLoS One 9 (11), e111653 (2014)
   PUBMED   25397408
  REMARK    GeneRIF: ZNF667 that confers cytoprotection is a novel regulator of
            the rat Bax gene.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3396)
  AUTHORS   Wang,G., Jiang,L., Song,J., Zhou,S.F., Zhang,H., Wang,K. and
            Xiao,X.
  TITLE     Mipu1 protects H9c2 myogenic cells from hydrogen peroxide-induced
            apoptosis through inhibition of the expression of the death
            receptor Fas
  JOURNAL   Int J Mol Sci 15 (10), 18206-18220 (2014)
   PUBMED   25310648
  REMARK    GeneRIF: Mip1 over-expression inhibited H2O2-induced apoptosis and
            upregulation of Fas induced by H2O2 in H9c2 myogenic cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3396)
  AUTHORS   Lai,C.F., Lin,S.L., Chiang,W.C., Chen,Y.M., Wu,V.C., Young,G.H.,
            Ko,W.J., Kuo,M.L., Tsai,T.J. and Wu,K.D.
  TITLE     Blockade of cysteine-rich protein 61 attenuates renal inflammation
            and fibrosis after ischemic kidney injury
  JOURNAL   Am J Physiol Renal Physiol 307 (5), F581-F592 (2014)
   PUBMED   24920753
REFERENCE   4  (bases 1 to 3396)
  AUTHORS   Wang,K., Lei,J., Zou,J., Xiao,H., Chen,A., Liu,X., Liu,Y.,
            Jiang,L., Xiao,Z. and Xiao,X.
  TITLE     Mipu1, a novel direct target gene, is involved in hypoxia inducible
            factor 1-mediated cytoprotection
  JOURNAL   PLoS One 8 (12), e82827 (2013)
   PUBMED   24349374
  REMARK    GeneRIF: Mipu1 is involved in HIF-1-mediate cytoprotection by
            inhibiting the expression of Bax and interfering activation of
            mitochondrial apoptotic pathway.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3396)
  AUTHORS   Qu,S., Zhu,H., Wei,X., Zhang,C., Jiang,L., Liu,Y., Luo,Q. and
            Xiao,X.
  TITLE     Oxidative stress-mediated up-regulation of myocardial ischemic
            preconditioning up-regulated protein 1 gene expression in H9c2
            cardiomyocytes is regulated by cyclic AMP-response element binding
            protein
  JOURNAL   Free Radic Biol Med 49 (4), 580-586 (2010)
   PUBMED   20488243
  REMARK    GeneRIF: The H(2)O(2)-induced up-regulation of Mipu1 in H9c2
            cardiomyocytes was mediated by cAMP/PKA-dependent CREB activation.
REFERENCE   6  (bases 1 to 3396)
  AUTHORS   Wang,G., Zuo,X., Jiang,L., Wang,K., Wei,X., Zhang,B. and Xiao,X.
  TITLE     Tissue expression and subcellular localization of Mipu1, a novel
            myocardial ischemia-related gene
  JOURNAL   Braz J Med Biol Res 43 (1), 43-51 (2010)
   PUBMED   19649394
  REMARK    GeneRIF: Results found that Mipu1 was highly expressed in the heart
            and brain of rats and was localized in the nucleus of H9c2 myogenic
            cells and lay the foundation for further study of the biological
            functions of Mipu1.
REFERENCE   7  (bases 1 to 3396)
  AUTHORS   Lv,B., Tang,Y., Li,X., Wang,G., Yuan,C., Liu,Y., Jiang,L. and
            Xiao,X.
  TITLE     Identification and characterization of the minimal promoter of
            Mipu1: the role of GC boxes in the regulation of basal
            transcription
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 41 (4), 309-315 (2009)
   PUBMED   19352546
  REMARK    GeneRIF: Results indicate that the GC boxes are essential for the
            activity of the Mipu1 minimal promoter activity
REFERENCE   8  (bases 1 to 3396)
  AUTHORS   Wang,G., Zuo,X., Yuan,C., Zheng,Y., Jiang,L., Song,J., Liu,Y.,
            Zhang,B. and Xiao,X.
  TITLE     Mipu1, a novel rat zinc-finger protein, inhibits transcriptional
            activities of AP-1 and SRE in mitogen-activated protein kinase
            signaling pathway
  JOURNAL   Mol Cell Biochem 322 (1-2), 93-102 (2009)
   PUBMED   19015817
  REMARK    GeneRIF: These results suggested that Mipu1 protein might act as a
            transcriptional repressor in mitogen-activated protein kinase
            (MAPK) signaling pathway to mediate cellular functions
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY221750.1.
            
            On Dec 17, 2004 this sequence version replaced XM_218238.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY221750.1, FQ121180.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132263 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..3396
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="W"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q12"
     gene            1..3396
                     /gene="Zfp667"
                     /gene_synonym="Mip1; Znf667"
                     /note="zinc finger protein 667"
                     /db_xref="GeneID:308326"
                     /db_xref="RGD:1359114"
     exon            1..70
                     /gene="Zfp667"
                     /gene_synonym="Mip1; Znf667"
                     /inference="alignment:Splign:2.1.0"
     exon            71..152
                     /gene="Zfp667"
                     /gene_synonym="Mip1; Znf667"
                     /inference="alignment:Splign:2.1.0"
     CDS             120..1946
                     /gene="Zfp667"
                     /gene_synonym="Mip1; Znf667"
                     /note="myocardial ischemic preconditioning up-regulated
                     protein 1; myocardial ischemic preconditioning upregulated
                     1"
                     /codon_start=1
                     /product="zinc finger protein 667"
                     /protein_id="NP_001008557.1"
                     /db_xref="GeneID:308326"
                     /db_xref="RGD:1359114"
                     /translation="MPAARGKSKSKAPVTFGDLAIYFSQEEWEWLSPNQKDLYEDVML
                     ENYHNLVSVGLACRRPNIIALLEKGKAPWMVEPSRKRRGPELGSKDETKKLPPSQCNK
                     SGPSICKKPDSSQQKVPTEKAKHNKNAVPRKNKKGHSGKKSLKCNSCGKTFFRSLSLK
                     LHQGFHTGERSYECSTCGQVFRQILSLILHQRVHTQNKSYECDKCGDIFNKKLTLMIH
                     RRSHNGKENFHHEKTSDSCPSLSPHHNNHAIDSIHQCRKCGKVFSRMSSLLLHKKIHN
                     RKRIQKYSACGRGFKKKPVLVHKRICIGKKTHENKALIQSLRQRTYQSENPFTCRKCR
                     KSFSRISALMLHQRAHTSGNPYKCDKCQKDFGRLSTLILHLRIHSGEKQFKCNKCEKV
                     CNRLSSFIQHKKIHKRKKKLIECKECGKMFGGMKNLKVHLNIHSEEKPFKCNKCSKVF
                     GRQSFLSEHQRIHTGEKPYQCEECGKAFSHRISLTRHKRIHSEDRPYECDLCGKAFSQ
                     SAHLAQHERIHTGEKPYACKICKKSFTQRISLILHERSHTGEKPYECNECGKAFSSGS
                     DLIRHQRSHSSEKPYECSKCGKAYSRSSSLIRHQSIHSEEMS"
     exon            153..279
                     /gene="Zfp667"
                     /gene_synonym="Mip1; Znf667"
                     /inference="alignment:Splign:2.1.0"
     exon            280..372
                     /gene="Zfp667"
                     /gene_synonym="Mip1; Znf667"
                     /inference="alignment:Splign:2.1.0"
     exon            373..3384
                     /gene="Zfp667"
                     /gene_synonym="Mip1; Znf667"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcaggcgcgg gggctctgtt gctggcagtt ctgtggcagc tgtgagacgg aggacgctgt
       61 agggagatag ctctcggtct cagtctctga atgtggaccg tcaaagctgg gaggaaagaa
      121 tgcctgcagc ccgagggaaa tcaaaatcca aggcaccagt gacttttggg gacttagcca
      181 tctacttctc acaggaggaa tgggaatggc tgagtcccaa tcagaaggat ttgtacgaag
      241 atgtcatgtt ggagaactat cacaatctgg tctcagttgg acttgcctgc cggaggccaa
      301 atatcatcgc cttgttggag aaagggaaag caccatggat ggtggagcca tcaagaaagc
      361 gccggggtcc tgaattaggg tctaaggatg agaccaagaa gttaccacca agtcaatgta
      421 acaaatctgg gccaagcatc tgtaagaaac cagattcttc acaacaaaag gttcccacag
      481 agaaggcaaa acataacaag aatgcagtcc caagaaaaaa caagaaaggg cattcaggca
      541 agaaatcttt aaagtgtaat agctgtggga aaaccttttt tcgaagctta tctcttaaac
      601 tccatcaagg ctttcacact ggagagaggt cttatgagtg cagtacttgt ggacaagttt
      661 tcaggcagat cttatctctc attcttcacc agagagttca cactcagaat aaaagctatg
      721 aatgtgataa gtgtggggac atttttaata aaaagttaac tctgatgatt catagaagaa
      781 gtcataatgg aaaggaaaat tttcaccatg agaagacttc agattcatgc ccatccctca
      841 gtccacacca taataatcac gctattgaca gcattcacca gtgcagaaaa tgtgggaaag
      901 tcttcagccg gatgtcatcc cttttacttc ataagaagat tcacaacaga aagagaatac
      961 aaaaatacag tgcatgtggg agaggcttca aaaagaagcc agtccttgta cataaaagaa
     1021 tttgtattgg gaagaaaact catgaaaata aggccttaat tcaaagtctc aggcagagaa
     1081 cttaccagtc agaaaaccct tttacgtgta ggaaatgcag gaagtccttt agtaggatct
     1141 cagccttaat gcttcatcag agagctcaca cttcagggaa cccctacaaa tgtgataagt
     1201 gtcagaaaga cttcggacga ctttcaaccc ttattctgca cctcagaatt catagtgggg
     1261 agaagcagtt taagtgcaac aagtgtgaga aggtatgcaa tcgcctttca tcctttattc
     1321 agcacaagaa aatccataaa aggaaaaaga aactcatcga gtgcaaggaa tgtggaaaga
     1381 tgtttggtgg aatgaaaaac cttaaagtac atctcaacat ccattcggag gagaaacctt
     1441 tcaagtgcaa taagtgtagt aaagtttttg gccgtcagtc atttcttagt gaacatcaaa
     1501 gaattcatac tggagagaag ccctatcagt gtgaagaatg tgggaaagcc ttcagtcacc
     1561 ggatctctct tacccgacat aagagaattc acagcgagga cagaccttac gaatgtgacc
     1621 tgtgtgggaa agccttcagc cagagtgctc atcttgctca gcatgaaaga attcacactg
     1681 gagagaagcc ttacgcgtgc aaaatatgta agaagtcctt cactcagcgc atatccctca
     1741 ttctacatga aagaagtcac actggggaga agccttacga gtgtaatgaa tgtgggaagg
     1801 cattcagtag tggctcagac cttatccgac atcagcgaag tcattcttca gagaaaccat
     1861 atgaatgtag caaatgtggt aaggcatata gccggagctc atctctgatt cgacatcaga
     1921 gtatacattc ggaggaaatg tcctaaggct gtcgctatat ctgcaaaagc taaaaaggac
     1981 atcaaagaag tgttcagaga catggaggat gtgtgtaagt gttcttgact tatgatgacg
     2041 tatgtcccaa taaacccatc gtaagttgaa gcgtctgaga caaacagata tttaatatac
     2101 ctgacctacc aaatgtgatc atttagcagc acagtgtaat gtggagtccc agttgttcat
     2161 tctcctgact gtatggcttt ctggaagcca tggcctgatc ccgctgccca gcattgtgag
     2221 agttagtatc ctgcgtacca tccgcctagg tcacttttac ccaattccta gttgaatgga
     2281 tattgcttct gtactatcgt aatgctaaaa aaatcataaa ttgggaacta tctgcctata
     2341 acatattttg tgtatgtggg gccgttataa tattctccct ttgaaagcca aagaacaaaa
     2401 gtagttggtg gattttgaag tgaagatctg aaatcagctg aggtatgctc agaattttgg
     2461 atcagggttt gtgaatgaag gtgtttttca attggcattt ctagtgtagt ggagctttga
     2521 gcctgagttg aggtcccagg aaaatagagt attaagtcta acaggcaaac caggcaaagt
     2581 agggtgcctc tttctcctga cagatctgtg ttggggtgag aacaaaaaga gtgagtcttt
     2641 aggttgctag aaatagtagc tacagtggat gtggaaaagt agtcaatacc acaaaagata
     2701 ccctgagaaa attttttaag acaagctggg ggcttgggca ggagatactg aaaaatgagg
     2761 aacttcagag cagggagaag ctatttttta cttttttact tgaaaataaa ctgtctatat
     2821 ttatataagt aaacagtgtt ttcatgcaat atttccagtt gctgtacaaa aaattactct
     2881 tgagatacat gtttgggttt tcatggtctg gatatttgtg ccaccccaaa actcatatgt
     2941 tgaagcccta acccttcaat atggtgatat tttgaaatga gattaatgaa gtcatgatgt
     3001 ggatgggcct ttttgatacg ctttgatcag acacacaaga aggctttgtc ttcttctgtc
     3061 ccatgcaaga acacaggcag gccatctgca aaccaaggaa aaaccctcac cagaacctga
     3121 ccagtttggt actctcacct tggacttcag cttatagcgg aactacgagg acctagtttc
     3181 tctgaagtca gcctgtctgt gatactgtgt tatagagcac ctcaaactga ttagttcgtg
     3241 gaagaactcc taggttaagg tactggctgt tttcctttgt cctgtccaac acgttcaatg
     3301 tatttttttt ggtctccttt tccagcctct gtaagctatt taaaataaag tctgaattct
     3361 tttgtgtgat taggtcatac acaaaaaaaa aaaaaa
//
